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Cyanogen chloride

RTECS #: GT2275000

CAS #: 506-77-4


UPDATE: May 2009 MW: 61.47 MF: CClN


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Chlorcyan
  2. Chlorine cyanide
  3. Chlorocyan
  4. Chlorocyanide
  1. Chlorocyanogen
  2. Chlorure de cyanogene (French)
  3. Cyanogen chloride (ACGIH)
  4. RCRA waste number P033


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 10 mg/m3 Eye: Lacrimation

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
WHOTAC -,31,1970
inhalation
human
lowest published toxic concentration: 2 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
TOVEFN (2),39,2001
inhalation
human
lowest published toxic concentration: 60 mg/m3 Eye: Lacrimation

Eye: Change in extra- ocular muscles
TOVEFN (2),39,2001
inhalation
human
lowest published lethal concentration: 400 mg/m3/10 minute Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOVEFN (2),39,2001
inhalation
man
lowest published toxic concentration: 2 gm/m3 Skin: After topical application: Primary irritation NTIS** PB158-508
inhalation
rat
lethal concentration (50 percent kill): 600 mg/m3/4 hour N/R TOVEFN (2),39,2001
oral
cat
lethal dose (50 percent kill): 6 mg/kg N/R ENTOX* -,701,2005
subcutaneous
dog
lowest published lethal dose: 5 mg/kg N/R HBAMAK 4,1341,1935
subcutaneous
pigeon
lowest published lethal dose: 8,700 g/kg N/R HBAMAK 4,1341,1935
subcutaneous
rabbit
lowest published lethal dose: 20 mg/kg N/R HBAMAK 4,1341,1935
unreported route
dog
lethal dose (50 percent kill): 3,300 g/kg N/R NTIS** PB158-508
unreported route
domestic animal
lethal dose (50 percent kill): 2,970 g/kg N/R NTIS** PB158-508
unreported route
rabbit
lethal dose (50 percent kill): 3,150 g/kg N/R NTIS** PB158-508


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.3 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
CPEMM* 3,239,2002
TOXICOLOGY REVIEW
ENTOX* -,701,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA ceiling concentration 0.3 ppm (0.75 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.3 ppm (0.76 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 5 mg(CN)/m3, OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.3 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 0.3 ppm (0.6 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 2 mg(CN)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg(CN)/m3, short term exposure limit 20 mg(CN)/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA ceiling concentration 0.3 ppm (0.6 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg(CN)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.6 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 0.3 ppm (0.75 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.25 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.2 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 ppm (0.3 mg/m3);
short term exposure limit 0.3 ppm (0.8 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.3 ppm (0.8 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.3 ppm (0.77 mg/m3), 2005
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg(CN)/m3 (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.3 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.3 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CYANOGEN CHLORIDE-air ceiling concentration 0.3 ppm NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84337;
Number of Industries 1;
Total Number of Facilities 34;
Number of Occupations 1;
Total Number of Employees Exposed 134
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84337;
Number of Industries 1;
Total Number of Facilities 4;
Number of Occupations 16;
Total Number of Employees Exposed 1,391


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101207/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9033
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE

CPEMM* Clinical Pediatric Emergency Medicine (Philadelphia, PA : W.B. Saunders Co.)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
WHOTAC World Health Organization, Technical Report Series. (WHO, 1211 Geneva, 27, Switzerland) No.1- 1950-

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Human Data

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