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Chlorine fluoride

RTECS #: FO2800000

CAS #: 7790-91-2


UPDATE: May 2009 MW: 92.45 MF: ClF3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Chlorine trifluoride
  2. Chlorine trifluoride (ACGIH:OSHA)
  1. Chlorotrifluoride
  2. Trifluorure de chlore (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
dog
21 ppm/12 hour- intermittent N/R AMIHAB 12,515,1955
eye
rat
21 ppm/12 hour- intermittent N/R AMIHAB 12,515,1955


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 1,800 mg/m3/2 minute Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,386,1989
inhalation
dog
lowest published toxic concentration: 1,800 mg/m3/5 minute Eye: Lacrimation

Eye: Corneal damage
VCVN5* -,386,1989
inhalation
dog
lowest published lethal concentration: 360 mg/m3/4 hour N/R VCVN5* -,386,1989
inhalation
human
lowest published lethal concentration: 50 ppm N/R 34ZIAG -,651,1966
inhalation
mammal (species unspecified)
lowest published toxic concentration: 80 mg/m3/10 minute Lung, Thorax, or Respiration: Cough VCVN5* -,386,1989
inhalation
monkey
lethal concentration (50 percent kill): 230 ppm/1 hour Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis
AMRL** TR-70-77,1970
inhalation
mouse
lethal concentration (50 percent kill): 178 ppm/1 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis
AMRL** TR-70-77,1970
inhalation
rat
lethal concentration (50 percent kill): 299 ppm/1 hour N/R TXAPA9 42,417,1977
inhalation
rat
lowest published lethal concentration: 3,000 mg/m3/15 minute N/R VCVN5* -,385,1989
inhalation
rat
lowest published lethal concentration: 1,500 mg/m3/35 minute N/R VCVN5* -,386,1989
inhalation
rabbit
lowest published toxic concentration: 1,800 mg/m3/2 minute Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,386,1989
inhalation
rabbit
lowest published toxic concentration: 1,800 mg/m3/5 minute Eye: Lacrimation

Eye: Corneal damage
VCVN5* -,386,1989
inhalation
rabbit
lowest published lethal concentration: 360 mg/m3/4 hour N/R VCVN5* -,386,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 5,150 ppb/6 hour/6 week- intermittent Eye: Corneal damage

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 12,515,1955
inhalation
dog
lowest published toxic concentration: 1,170 ppb/6 hour/26 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 13,340,1956
inhalation
dog
lowest published toxic concentration: 20 mg/m3/6 hour/6 week- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,386,1989
inhalation
mammal (species unspecified)
lowest published toxic concentration: 2 mg/m3/17 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Musculoskeletal: Other changes
STGNBT -,239,1999
inhalation
mammal (species unspecified)
lowest published toxic concentration: 4 mg/m3/6 hour/26 week- intermittent Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVN5* -,386,1989
inhalation
mammal (species unspecified)
lowest published toxic concentration: 4 mg/m3/6 hour/8 week- intermittent Lung, Thorax, or Respiration: Other changes VCVN5* -,386,1989
inhalation
rat
lowest published toxic concentration: 5,150 ppb/6 hour/6 week- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Changes in structure or function of salivary glands

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 12,515,1955
inhalation
rat
lowest published toxic concentration: 1,170 ppb/6 hour/26 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 13,340,1956
inhalation
rat
lowest published toxic concentration: 20 mg/m3/6 hour/6 week- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,386,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.1 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2.5 mg(F)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
TXAPA9 27,527,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 0.1 ppm (0.4 mg/m3) DTLWS* 3,11,1972
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 ppm (0.4 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 ppm (0.4 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 ppm (0.4 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 ppm (0.4 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA ceiling concentration 0.1 ppm (0.38 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg(F)/m3, JUL2008
Occupational Exposure Limit - BELGIUM short term exposure limit 0.1 ppm (0.39 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg(F)/m3, MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 0.1 ppm (0.4 mg/m3), OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg(F)/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 2.5 mg(F)/m3, FEB 2006
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VLE 0.4 mg/m3, FEB2006
Occupational Exposure Limit - GERMANY MAK 1 mg(F)/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 2.5 mg(F)/m3, short term exposure limit 10 mg(F)/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA ceiling concentration 0.1 ppm (0.4 mg/m3), 2006
Occupational Exposure Limit - MEXICO peak 0.1 ppm (0.4 mg/m3), 2004
Occupational Exposure Limit - MEXICO time-weighted average 2.5 mg(F)/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.4 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 0.1 ppm (0.38 mg/m3), JAN2002
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2.5 mg(F)/m3, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg(HF)/m3, MAC(short term exposure limit) 3 mg(HF)/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.4 mg/m3);
KZG- week 0.1 ppm (0.4 mg/m3),DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg(F)/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORINE TRIFLUORIDE-air ceiling concentration 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18050;
Number of Industries 1;
Total Number of Facilities 11;
Number of Occupations 3;
Total Number of Employees Exposed 357


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used in fluorinations and nuclear fuel processing and as rocket propellant and igniter

NIOSH PROFILE (CHLORINES, INORGANIC), SRC, 4/78

RTECS Compound Description:
   Human Data
   Primary Irritant

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