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Carbon disulfide

RTECS #: FF6650000

CAS #: 75-15-0


UPDATE: May 2009 MW: 76.13 MF: CS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Carbon bisulfide
  2. Carbon bisulphide
  3. Carbon disulphide
  4. Carbon disulfide (ACGIH:OSHA)
  5. Carbone (sufure de) (French)
  6. Carbonio (solfuro di) (Italian)
  7. Dithiocarbonic anhydride
  8. Kohlendisulfid (schwefelkohlenstoff) (German)
  1. Koolstofdisulfide (zwavelkoolstof) (Dutch)
  2. NCI - C04591
  3. RCRA waste number P022
  4. Schwefelkohlenstoff (German)
  5. Solfuro di carbonio (Italian)
  6. Sulphocarbonic anhydride
  7. Weeviltox
  8. Wegla dwusiarczek (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 100 L/plate (+enzymatic activation step) NIOSH* 5AUG1977
sister chromatid exchange human lymphocyte 8 mg/L TCMUD8 10,21,1990
sister chromatid exchange human lymphocyte 10,200 g/L BCTKAG 14,115,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
man
lowest published toxic concentration: 40 mg/m3 (91 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MELAAD 60,566,1969
inhalation
mouse
lowest published toxic concentration: 2,000 mg/m3/2 hour (1-21 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
BEXBAN 68,1158,1969
inhalation
mouse
lowest published toxic concentration: 10 mg/m3/2 hour (3 week prior to copulation) Reproductive: Effects on fertility: Other measures of fertility WDZAEK 4,139,1990
inhalation
rat
lowest published toxic concentration: 200 mg/m3/24 hour (1-21 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) KHZDAN 21,257,1978
inhalation
rat
lowest published toxic concentration: 10 mg/m3/8 hour (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
ATSUDG 4,252,1980
inhalation
rat
lowest published toxic concentration: 100 mg/m3/8 hour (1-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOLED5 2,129,1978
inhalation
rat
lowest published toxic concentration: 100 mg/m3/8 hour (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Homeostasis
TJADAB 14,374,1976
inhalation
rat
lowest published toxic concentration: 30 g/m3/8 hour (1-22 day pregnant) Reproductive: Effects on newborn: Behavioral ATSUDG 4,252,1980
inhalation
rat
lowest published toxic concentration: 600 ppm/6 hour (50 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TXAPA9 73,275,1984
oral
rat
lowest published toxic dose: 2,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB84-192343
oral
rabbit
lowest published toxic dose: 350 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TOXID9 4,86,1984
oral
rabbit
lowest published toxic dose: 2,100 mg/kg (6-19 day pregnant) Reproductive: Other developmental abnormalities TOXID9 4,86,1984
oral
rabbit
lowest published toxic dose: 350 mg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
NTIS** #PB84-192350
oral
rabbit
lowest published toxic dose: 2,100 mg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB84-192350


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published lethal concentration: 4,000 ppm/30 minute N/R 29ZWAE -,118,1968
inhalation
human
lowest published lethal concentration: 2,000 ppm/5 minute N/R TABIA2 3,231,1933
inhalation
human
lowest published toxic concentration: 0.8 mg/m3 Olfaction: Change in sensation of smell VCVN5* -,208,1993
inhalation
human
lowest published toxic concentration: 0.4 mg/m3 Brain and Coverings: Recordings from specific areas of CNS

Eye: Other eye effects
VCVN5* -,208,1993
inhalation
human
lowest published lethal concentration: 10,000 mg/m3 Eye: Other eye effects

Behavioral: General anesthetic

Behavioral: Ataxia
VCVN5* -,208,1993
inhalation
human
lowest published toxic concentration: 1,500 mg/m3/30 minute Behavioral: Headache

Gastrointestinal: Nausea or vomiting
VCVN5* -,209,1993
inhalation
human
lowest published toxic concentration: 3,600 mg/m3 Peripheral Nerve and Sensation: Paresthesia

Lung, Thorax, or Respiration: Cough
VCVN5* -,209,1993
inhalation
mammal (species unspecified)
lowest published lethal concentration: 2,000 ppm/5 minute N/R AEPPAE 138,65,1928
inhalation
mouse
lethal concentration (50 percent kill): 10 gm/m3/2 hour N/R 85GMAT -,32,1982
inhalation
mouse
lethal concentration (50 percent kill): 10,000 mg/m3 N/R VCVN5* -,207,1993
inhalation
rat
lethal concentration (50 percent kill): 25 gm/m3/2 hour N/R 85GMAT -,32,1982
inhalation
rat
lethal concentration (50 percent kill): 25,000 mg/m3 N/R VCVN5* -,207,1993
inhalation
rat
lethal concentration (50 percent kill): 1,000 mg/m3 Behavioral: Alteration of classical conditioning VCVN5* -,207,1993
inhalation
rat
lowest published lethal concentration: 20,000 mg/m3/1 hour Behavioral: Excitement

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
VCVN5* -,207,1993
intraperitoneal
guinea pig
lowest published lethal dose: 400 mg/kg Liver: Fatty liver degeneration AIHAAP 35,21,1974
intraperitoneal
rat
lowest published toxic dose: 7.6 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) TOXID9 66,126,2002
oral
guinea pig
lethal dose (50 percent kill): 2,125 mg/kg N/R VCVN5* -,207,1993
oral
mouse
lethal dose (50 percent kill): 2,780 mg/kg N/R VCVN5* -,207,1993
oral
rat
lethal dose (50 percent kill): 1,200 mg/kg N/R INHEAO 32,145,1994
oral
rabbit
lethal dose (50 percent kill): 2,550 mg/kg N/R VCVN5* -,207,1993
unreported route
man
lowest published lethal dose: 186 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 1,250 mg/m3/8 hour/11 week- intermittent Brain and Coverings: Other degenerative changes

Eye: Other eye effects

Cardiac: EKG changes not diagnostic of above
JIHTAB 23,415,1941
inhalation
human
lowest published toxic concentration: 9 mg/m3/3 year- intermittent Gastrointestinal: Other changes

Liver: Other changes
VCVN5* -,212,1989
inhalation
human
lowest published toxic concentration: 10 mg/m3/10 year- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Irritability

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS
VCVN5* -,213,1989
inhalation
human
lowest published toxic concentration: 15 mg/m3/10 year- intermittent Cardiac: Cardiomyopathy including infarction

Vascular: BP elevation not characterized in autonomic section
VCVN5* -,215,1989
inhalation
man
lowest published toxic concentration: 30 mg/m3/10 year- intermittent Endocrine: Change in LH

Endocrine: Change in gonadotropins
JTEHD6 7,363,1981
inhalation
monkey
lowest published toxic concentration: 1,200 mg/m3/6 hour/20 week- intermittent Endocrine: Hyperglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
ENVRAL 29,151,1982
inhalation
monkey
lowest published toxic concentration: 160 ppm/6 hour/36 day Eye: Other eye effects TOXID9 3,63,1983
inhalation
mouse
lowest published toxic concentration: 114 mg/m3/8 hour/20 week- intermittent Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 18,733,1936
inhalation
mouse
lowest published toxic concentration: 0.18 mg/m3/3 hour/4 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
VCVN5* -,210,1989
inhalation
mouse
lowest published toxic concentration: 0.18 mg/m3/3 hour/8 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Cl
VCVN5* -,210,1989
inhalation
rat
lowest published toxic concentration: 10 mg/m3/5 hour/13 week- intermittent Brain and Coverings: Other degenerative changes

Endocrine: Other changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
KHZDAN 25,339,1982
inhalation
rat
lowest published toxic concentration: 2,000 ppm/4 hour/2 week- intermittent Behavioral: Change in psychophysiological tests

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AIHAAP 25,369,1964
inhalation
rat
lowest published toxic concentration: 114 mg/m3/8 hour/20 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 18,733,1936
inhalation
rat
lowest published toxic concentration: 800 ppm/6 hour/12 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TXAPA9 94,356,1988
inhalation
rat
lowest published toxic concentration: 1,500 mg/m3/5 hour/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Lipids including transport
TOLED5 10,139,1982
inhalation
rat
lowest published toxic concentration: 800 mg/m3/5 hour/1 year- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOLED5 10,139,1982
inhalation
rat
lowest published toxic concentration: 500 ppm/24 hour/25 week- continuous Peripheral Nerve and Sensation: Recording from afferent nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 34,175,1986
inhalation
rat
lowest published toxic concentration: 800 ppm/6 hour/15 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
ARTODN 66,334,1992
inhalation
rat
lowest published toxic concentration: 2,300 mg/m3/2 hour/12 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Gastrointestinal: Alteration in gastric secretion

Gastrointestinal: Gastritis
VCVN5* -,209,1989
inhalation
rat
lowest published toxic concentration: 10 mg/m3/24 hour/70 day- continuous Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Emphysema

Liver: Other changes
VCVN5* -,210,1989
inhalation
rat
lowest published toxic concentration: 0.18 mg/m3/3 hour/4 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
VCVN5* -,210,1989
inhalation
rat
lowest published toxic concentration: 0.18 mg/m3/3 hour/8 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Changes in: Cl
VCVN5* -,210,1989
inhalation
rat
lowest published toxic concentration: 1 mg/m3/24 hour/17 week- continuous Cardiac: Other changes

Cardiac: Changes in heart weight

Vascular: BP elevation not characterized in autonomic section
VCVN5* -,212,1989
inhalation
rat
lowest published toxic concentration: 100 mg/m3/3 hour/6 week- intermittent Endocrine: Evidence of thyroid hyperfunction

Endocrine: Adrenal cortex hypoplasia

Endocrine: Effect on menstrual cycle
GTPRZ* 13,42,1969
inhalation
rat
lowest published toxic concentration: 100 mg/m3/17 week- intermittent Cardiac: Changes in coronary arteries

Vascular: Structural changes in vessels
TPKVAL 15,3,1979
inhalation
rat
lowest published toxic concentration: 0.2 gm/m3/122 day- intermittent Brain and Coverings: Changes in circulation

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Kidney, Ureter, and Bladder: Changes in blood vessels or in circulation of kidney
TPKVAL 4,117,1962
inhalation
rat
lowest published toxic concentration: 700 mg/m3/14 week- intermittent Cardiac: Changes in heart weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
JTEHF8 68,797,2005
inhalation
rabbit
lowest published toxic concentration: 10 mg/m3/2 hour/50 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase VCVN5* -,211,1989
inhalation
woman
lowest published toxic concentration: 9.36 mg/m3/1 year- intermittent Endocrine: Change in gonadotropins

Endocrine: Effect on menstrual cycle

Endocrine: Other changes
AAMST* 43,255,1997
intraperitoneal
rat
lowest published toxic dose: 3 gm/kg/3 day- intermittent Spinal Cord: Other degenerative changes TOXID9 8,245,1988
intraperitoneal
rat
lowest published toxic dose: 6,475 mg/kg/4 week- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
WDZAEK 6,195,1992
intraperitoneal
rat
lowest published toxic dose: 5,600 mg/kg/35 day- intermittent Cardiac: Other changes

Vascular: Structural changes in vessels

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
WDZAEK 6,131,1992
oral
mouse
lowest published toxic dose: 5,512 mg/kg/5 day- intermittent Endocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JTEHD6 47,479,1996
oral
rat
lowest published toxic dose: 5,055 mg/kg/4 week- intermittent Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Pulse rate decreased with fall in BP

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BBIADT 49,121,1990
oral
rat
lowest published toxic dose: 4,000 mg/kg/10 day- continuous Liver: Changes in liver weight

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** #PB84-192343
oral
rat
lowest published toxic dose: 4,000 mg/kg/10 day- continuous Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Sleep
NTIS** #PB84-192343
oral
rat
lowest published toxic dose: 2,000 mg/kg/10 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB84-192343
oral
rabbit
lowest published toxic dose: 25,298 mg/kg/26 week- intermittent Cardiac: Changes in heart weight

Endocrine: Hyperglycemia

Immunological Including Allergic: Decrease in cellular immune response
GISAAA 31(1),13,1966
oral
rabbit
lowest published toxic dose: 2,100 mg/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB84-192350
oral
rabbit
lowest published toxic dose: 1,050 mg/kg/14 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB84-192350


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
CRTXB2 2,365,1973
TOXICOLOGY REVIEW
AIHAAP 35,55,1974
TOXICOLOGY REVIEW
KHZDAN 16,208,1973
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
TOLED5 134,17,2002
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 20 ppm (60 mg/m3) (skin) DTLVS* 3,39,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 20 ppm;
ceiling concentration 30 ppm;
peak concentration 100 ppm/30 minute/8 hour
CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 20 ppm (60 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 20 ppm (60 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 20 ppm (60 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 10 ppm (30 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (31 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (31 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (15 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (15 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (30 mg/m3), VLE 25 ppm (75 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 16 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 30 mg/m3, short term exposure limit 120 mg/m3, Skin, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 10 ppm (30 mg/m3), Skin, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 ppm (31 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (30 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (30 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 30 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (31 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (15 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 20 ppm (60 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 18 mg/m3, MAC(short term exposure limit) 30 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 3 mg/m3, short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 5 ppm (16 mg/m3);
short term exposure limit 8 ppm (25 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (15 mg/m3),KZG- week 10 ppm (30 mg/m3), Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 20 ppm (60 mg/m3), short term exposure limit 30 ppm (90 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 10 ppm (65 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (32 mg/m3) (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CARBON DISULFIDE-air 10 hour time-weighted average 1 ppm (Sk);
short term exposure limit 10 ppm (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 17370;
Number of Industries 24;
Total Number of Facilities 1,074;
Number of Occupations 27;
Total Number of Employees Exposed 24,200
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 17370;
Number of Industries 20;
Total Number of Facilities 751;
Number of Occupations 44;
Total Number of Employees Exposed 45,760;
Total Number of Female Employees Exposed 5,834


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121073/AS)
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for insect control in stored grain
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0393-8888
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Carbon disulfide, 1600


REFERENCES:

CODEN
REFERENCE

29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AAMST* Annales Academiae Medicae Stetinensis. (Pomorska Akademia Medyczna im. Generala Karola Swierczewskiego w Szczecinie, Szczecin.) V. 9- 1963-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BBIADT Biomedica Biochimica Acta. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.42- 1983-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPRZ* Gigiena truda i professional'nye zabolevaniia. (Moskva Izdatelstvo Meditsina. Continued by:Meditsina truda i promyshlennaia ekologiia) V.1- 1953-1992
HUTOX*
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JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
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Used for insect control in stored grain

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

NIOSH PROFILE (GRAIN HANDLERS), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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