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tert - Butyl alcohol

RTECS #: EO1925000

CAS #: 75-65-0


UPDATE: May 2009 MW: 74.14 MF: C4H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1,1 - Dimethylethanol
  2. 2 - Methyl - 2 - propanol
  3. 2 - Methylpropan - 2 - ol
  4. 2 - Propanol, 2 - methyl -
  5. Alcool butylique tertiaire (French)
  6. Arconol
  7. Butanol tertiaire (French)
  8. Butyl alcohol
  9. Methanol, trimethyl -
  1. NCI - C55367
  2. Tertiary - Butyl alcohol
  3. Trimethyl methanol
  4. Trimethylcarbinol
  5. t - Butanol
  6. t - Butyl alcohol
  7. t - Butyl hydroxide
  8. tert - Butanol
  9. tert - Butyl alcohol (OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 ÁL/24 hour severe NTIS** OTS0572351
skin
rabbit
500 ÁL/24 hour mild NTIS** OTS0572351


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis parenteral
other insects
12,500 mg/kg ENECEV 5,321,1989
mutation in microorganisms Salmonella typhimurium 2 mg/plate (+enzymatic activation step) MUREAV 446,15,1999


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 2,000 ppm/7 hour (1-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 12,469,1989
inhalation
rat
lowest published toxic concentration: 3,500 ppm/7 hour (1-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 12,469,1989
oral
mouse
lowest published toxic dose: 103 gm/kg (6-20 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JPETAB 222,294,1982
oral
mouse
lowest published toxic dose: 135 gm/kg (6-20 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) JPETAB 222,294,1982
oral
mouse
lowest published toxic dose: 20,240 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) LIFSAK 45,1989,1989
oral
mouse
lowest published toxic dose: 15,000 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
VCVGK* -,103,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 1,540 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors
NTPTR* NTP-TR-436,1995
oral
mouse
lowest published toxic dose: 749,840 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors
NTIS** PB96-162748
oral
mouse
lowest published toxic dose: 1,521,310 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Thyroid tumors
NTIS** PB96-162748
oral
rat
lowest published toxic dose: 146 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-436,1995
oral
rat
lowest published toxic dose: 144,200 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB96-162748
oral
rat
lowest published toxic dose: 468,650 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB96-162748


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
lowest published toxic dose: 72.5 mg/m3 Eye: Conjunctiva irritation VCVGK* -,103,1984
inhalation
rat
lethal concentration (50 percent kill): >10,000 ppm/4 hour Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Pulmonary emboli
NTIS** OTS0572351
intraperitoneal
mouse
lethal dose (50 percent kill): 399 mg/kg Liver: Other changes RCOCB8 26,75,1979
intraperitoneal
mouse
lethal dose (50 percent kill): 900 mg/kg N/R VCVGK* -,102,1984
intravenous
mouse
lethal dose (50 percent kill): 1,500 mg/kg N/R VCVGK* -,102,1984
oral
rat
lethal dose (50 percent kill): 2,743 mg/kg Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Other changes
NTIS** OTS0572351
oral
rat
lethal dose (50 percent kill): 3,500 mg/kg N/R VCVGK* -,102,1984
oral
rabbit
lethal dose (50 percent kill): 3,559 mg/kg Eye: Corneal damage

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Dyspnea
IMSUAI 41,31,1972
oral
rabbit
lethal dose (50 percent kill): 3,600 mg/kg N/R VCVGK* -,102,1984
oral
rabbit
lowest published lethal dose: 3,500 mg/kg N/R VCVGK* -,102,1984
parenteral
frog
lowest published lethal dose: 12 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)
AIPTAK 50,296,1935
skin
guinea pig
lethal dose (50 percent kill): >10 mL/kg Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair
NTIS** OTS0556680
skin
rabbit
lethal dose (50 percent kill): >2 gm/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0572351


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 500 ppm/6 hour/5 day- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
ATSUDG 8,418,1985
oral
mouse
lowest published toxic dose: 703 gm/kg/94 day- continuous Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 19,91,1992
oral
mouse
lowest published toxic dose: 6 gm/kg/5 day- intermittent Related to Chronic Data: Changes in testicular weight NTIS** OTS0559651
oral
rat
lowest published toxic dose: 73,176 mg/kg/21 day- continuous Behavioral: Convulsions or effect on seizure threshold

Behavioral: Withdrawal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
PUOMA5 54,86,1976
oral
rat
lowest published toxic dose: 150 gm/kg/94 day- continuous Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 19,91,1992
oral
rat
lowest published toxic dose: 9,545 ÁL/kg/10 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 80,97,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
JACTDZ 8,627,1989
TOXICOLOGY REVIEW
TOSCF2 61,1,2001
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
IJTOFN 24,1,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 659,68,2008
TOXICOLOGY REVIEW
MUREAV 672,10,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,290,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (300 mg/m3) DTLVS* 3,32,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (300 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (303 mg/m3), short term exposure limit 150 ppm (455 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (307 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 50 ppm (150 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 100 ppm (300 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 62 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (150 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 100 ppm (305 mg/m3), short term exposure limit 150 ppm (455 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 100 ppm (300 mg/m3);
short term exposure limit 150 ppm (450 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 300 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 100 ppm (303 mg/m3);
short term exposure limit 150 ppm (455 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (75 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 300 mg/m3, MAC(short term exposure limit) 450 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (150 mg/m3);
short term exposure limit 75 ppm (250 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (60 mg/m3);
KZG- week 80 ppm (240 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (300 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (308 mg/m3);
short term exposure limit 150 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO t-BUTYL ALCOHOL-air 10 hour time-weighted average 100 ppm;
short term exposure limit 150 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 14400;
Number of Industries 11;
Total Number of Facilities 820;
Number of Occupations 25;
Total Number of Employees Exposed 3,121
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 14400;
Number of Industries 128;
Total Number of Facilities 10,682;
Number of Occupations 84;
Total Number of Employees Exposed 171,420;
Total Number of Female Employees Exposed 26,045


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: N crassa-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent and emulsifier
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols I, 1400
NTP Carcinogenesis Studies (drinking water);some evidence:mouse,rat NTPTR* NTP-TR-436,1995
NCI Carcinogenesis Studies (water);equivocal evidence:mouse,rat
NTP Toxicity studies, RPT# TOX-53, October 2000


REFERENCES:

CODEN
REFERENCE

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENECEV Environment and Ecology. (Environment and Ecology, C/o Dr. S.K. Konar, Dept. of Zoology, Kalyani University, Kalyani 741253, West Bengal, India) V.1- 1983-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PUOMA5 Proceedings of the University of Otago Medical School. (Otago Medical School Research Soc., Box 913, Dunedin, New Zealand) V.1- 1922-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solvent and emulsifier

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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