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Registry of Toxic Effects of Chemical Substances (RTECS)

sec-Butyl alcohol

RTECS #

EO1750000

CAS #

78-92-2; 15892-23-6

Updated

September 201

Molecular Weight

74.14

Molecular Formula

C4H10O

Synonyms

(+-)-2-Butanol
1-Methyl propanol
1-Methyl-1-propanol
1-Methylpropyl alcohol
2-Butanol
2-Butyl alcohol
2-Hydroxybutane
Alcool butylique secondaire (French)
Butan-2-ol
Butanol secondaire (French)
Butanol-2
Butylene hydrate
CCS 301
DL-Butan-2-ol
dl-Methylethylcarbinol
Ethylmethyl carbinol
Methylethylcarbinol
Racemic-2-butanol
S.B.A.
s-Butanol
s-Butyl alcohol
sec-Butanol
sec-Butanol (ACGIH)
sec-Butyl alcohol (OSHA)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 0.1 mL severeHPV376 -,-,2006

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 5000 ppm/7H (1-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FAATDF 12,469,1989
inhalation/rat 7000 ppm/7H (1-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FAATDF 12,469,1989
inhalation/rat 5000 mg/kg (1-19D pregnant)Reproductive: Other effects on femaleHPV376 -,-,2006
oral/rat 284984 mg/kg (multigeneration)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV376 -,-,2006

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 3300 ppm/51MBehavioral: AtaxiaHPV376 -,-,2006
inhalation/mouse lowest published toxic concentration: 11800 ppm/10MLung, Thorax, or Respiration: Respiratory depressionHPV376 -,-,2006
inhalation/mouse lowest published toxic concentration: 19800 ppm/40MBehavioral: General anestheticHPV376 -,-,2006
inhalation/rat lethal concentration (50 percent kill): 48500 mg/m3/4HVCVGK* -,102,1984
inhalation/rat Lowest published lethal concentration: 16000 ppm/4HOlfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes
SHELL* MSDS-5280-4
inhalation/rat lethal concentration (50 percent kill): 8000 ppm/4HHPV376 -,-,2006
intraperitoneal/guinea pig lethal dose (50 percent kill): 1067 mg/kgEVHPAZ 61,321,1985
intraperitoneal/hamster lethal dose (50 percent kill): 1218 mg/kgEVHPAZ 61,321,1985
intraperitoneal/mouse lethal dose (50 percent kill): 771 mg/kgSCCUR* -,2,1961
intraperitoneal/rabbit lethal dose (50 percent kill): 277 mg/kgEVHPAZ 61,321,1985
intraperitoneal/rat lethal dose (50 percent kill): 1193 mg/kgEVHPAZ 61,321,1985
intravenous/mouse lethal dose (50 percent kill): 764 mg/kgAIPTAK 135,330,1962
intravenous/rat lethal dose (50 percent kill): 138 mg/kgEVHPAZ 61,321,1985
oral/Dog lowest published lethal dose: 2400 mg/kgNTIS** OTS0572377
oral/rabbit lethal dose (50 percent kill): 4893 mg/kgEye: Corneal damage

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Dyspnea
IMSUAI 41,31,1972
oral/rabbit lowest published lethal dose: 3000 mg/kgVCVGK* -,102,1984
oral/rabbit lethal dose (50 percent kill): 4890 mg/kgHPV376 -,-,2006
oral/rat lethal dose (50 percent kill): 2054 mg/kgHPV376 -,-,2006
oral/rat lethal dose (50 percent kill): 2193 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Behavioral: Coma
NTIS** OTS0557575
parenteral/frog lowest published lethal dose: 15 gm/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)
AIPTAK 50,296,1935
skin/rat lethal dose (50 percent kill): >2000 mg/kgHPV376 -,-,2006

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 500 ppm/6H/5D- intermittentKidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
ATSUDG 8,418,1985
inhalation/rat lowest published toxic concentration: 500 ppm/5D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
HPV376 -,-,2006
inhalation/rat lowest published toxic concentration: 5000 ppm/90D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
HPV376 -,-,2006

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 150 ppm (450 mg/m3)DTLVS* 3,32,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 100 ppm (303 mg/m3), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 100 ppm (307 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKceiling concentration 50 ppm (150 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 50 ppm (150 mg/m3), short term exposure limit 75 ppm (230 mg/m3), skin, NOV2011
Occupational Exposure Limit-FRANCEVME 100 ppm (300 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDshort term exposure limit 50 ppm (150 mg/m3), skin, NOV2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 100 ppm (300 mg/m3), MAY2012
Occupational Exposure Limit-KOREAceiling concentration 50 ppm (150 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 100 ppm (305 mg/m3);short term exposure limit 150 ppm (455 mg/m3), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 100 ppm (303 mg/m3), JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 25 ppm (75 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 100 ppm (303 mg/m3), JUL2005
Occupational Exposure Limit-POLANDtime-weighted average 300 mg/m3, short term exposure limit 450 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 50 ppm (150 mg/m3);short term exposure limit 75 ppm (250 mg/m3), Skin, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 100 ppm (300 mg/m3), KZG-week 200 ppm (600 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 450 mg/m3, 2003
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 150 ppm (450 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 150 ppm (450 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 100 ppm (308 mg/m3);short term exposure limit 150 ppm (462 mg/m3), OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 150 ppm (450 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 150 ppm (450 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 150 ppm (450 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 150 ppm (450 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO sec-BUTYL ALCOHOL-air10H time-weighted average 100 ppm;short term exposure limit 150 ppmNIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 14410; Number of Industries 97; Total Number of Facilities 5896; Number of Occupations 72; Total Number of Employees Exposed 126196; Total Number of Female Employees Exposed 36723
National Occupational Hazard Survey 1974Hazard Code 14410; Number of Industries 59; Total Number of Facilities 2929; Number of Occupations 47; Total Number of Employees Exposed 42853

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols II, 1401
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