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2,3 - Butanedione

RTECS #: EK2625000

CAS #: 431-03-8


UPDATE: November 2006 MW: 86.10 MF: C4H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2,3 - Butadione
  2. 2,3 - Diketobutane
  3. Biacetyl
  4. Diacetyl
  1. Dimethyl diketone
  2. Dimethylglyoxal
  3. Glyoxal, dimethyl -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg/24 hour moderate FCTXAV 17,765,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
unscheduled DNA synthesis oral
rat
1,500 mg/kg JJCREP 76,809,1985
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+enzymatic activation step) MUREAV 67,367,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 198.4 ppm/6 hour Olfaction: Other olfaction effects

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 78,438,2004
inhalation
rat
lowest published toxic concentration: 294.6 ppm/6 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 78,438,2004
intraperitoneal
rat
lethal dose (50 percent kill): 400 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)

Vascular: Regional or general arteriolar or venous dilation
FCTXAV 7,571,1969
oral
guinea pig
lethal dose (50 percent kill): 990 mg/kg Behavioral: Ataxia

Behavioral: Coma

Lung, Thorax, or Respiration: Dyspnea
FCTXAV 2,327,1964
oral
rat
lethal dose (50 percent kill): 1,580 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
FCTXAV 2,327,1964
oral
rat
lethal dose (50 percent kill): 3,000 mg/kg N/R VCVGK* -,448,1994
skin
rabbit
lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,765,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 200 ppm/5 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 90,210,2006
oral
rat
lowest published toxic dose: 48,600 mg/kg/90 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Blood: Pigmented or nucleated red blood cells
FCTXAV 7,571,1969
oral
rat
lowest published toxic dose: 48,600 mg/kg/90 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
VCVGK* -,448,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84595;
Number of Industries 3;
Total Number of Facilities 126;
Number of Occupations 6;
Total Number of Employees Exposed 1,503
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84595;
Number of Industries 3;
Total Number of Facilities 185;
Number of Occupations 13;
Total Number of Employees Exposed 3,438;
Total Number of Female Employees Exposed 1,628


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to flavour foods
NTP Carcinogenesis studies; selected, October 2000


REFERENCES:

CODEN
REFERENCE

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used to flavour foods

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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