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(1) Benzopyrano (3,4 - b) furo (2,3 - h) (1) benzopyran - 6 (6ah) - one, 1,2,12,12a - tetrahydro - 2 - alpha - isopropenyl - 8,9 - dimethoxy -

RTECS #: DJ2800000

CAS #: 83-79-4


UPDATE: May 2009 MW: 394.45 MF: C23H22O6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. ( - ) - Rotenone
  2. ( - ) - cis - Rotenone
  3. 5' - beta - Rotenone
  4. Barbasco
  5. Canex
  6. Cenol garden dust
  7. Chem fish
  8. Chem - Mite
  9. Cube
  10. Cube extract
  11. Cube root
  12. Cube - Pulver
  13. Cubor
  14. Curex flea duster
  15. Dactinol
  16. Deril
  17. Derrin
  18. Derris
  19. Derris (insecticide)
  20. Dri - Kil
  21. ENT 133
  22. Extrax
  23. Fish - Tox
  24. Gerane
  25. Green cross warble powder
  1. Haiari
  2. Liquid derris
  3. Mexide
  4. NCI - C55210
  5. Nekoe
  6. Nicouline
  7. Noxfish
  8. Paraderil
  9. Powder and root
  10. Prenfish
  11. Pro - Nox fish
  12. Ro - KO
  13. Ronone
  14. Rotefive
  15. Rotefour
  16. Rotenon
  17. Rotenona (Spanish)
  18. Rotenone
  19. Rotenone (ACGIH:OSHA)
  20. Rotenone commercial
  21. Rotenox 5EC
  22. Rotessenol
  23. Rotocide
  24. Synpren
  25. Tubatoxin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
1% mild PSEBAA 34,135,1936


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 100 ng/L/20 hour MUREAV 651,56,2008
DNA damage rat liver 15 mol/L MUREAV 368,59,1996
micronucleus test hamster lung 0.5 g/L/20 hour MUREAV 651,56,2008
micronucleus test human lymphocyte 250 g/L MUREAV 414,1,1998
micronucleus test mouse other cell types 1 mg/L JNCIAM 56,357,1976
mutation in mammalian somatic cells mouse lymphocyte 250 g/L EMMUEG 12,85,1988
morphological transform hamster embryo 5 g/L/7 day MUTAEX 20,51,2005
sister chromatid exchange hamster ovary 600 g/L NTPTR* NTP-TR-320,1988
sex chromosome loss and nondisjunction hamster lung 50 g/L MUREAV 263,173,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 288 mg/kg (6-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
HBPTO* 1,126,2001
oral
mouse
lowest published toxic dose: 504 mg/kg (1-21 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
HBPTO* 2,1185,2001
oral
rat
lowest published toxic dose: 100 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
JTEHD6 10,111,1982
oral
rat
lowest published toxic dose: 50 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JTEHD6 10,111,1982
oral
rat
lowest published toxic dose: 2,960 g/kg (6-9 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina BECTA6 28,360,1982
oral
rat
lowest published toxic dose: 98 mg/kg (6-15 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) BECTA6 28,360,1982
oral
rat
lowest published toxic dose: 132 mg/kg (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
HBPTO* 2,1185,2001
oral
rat
lowest published toxic dose: 50 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system HBPTO* 2,1185,2001
oral
rat
lowest published toxic dose: 132 mg/kg (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death HBPTO* 2,1185,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 71 mg/kg/42 day- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
CNREA8 33,3047,1973
intraperitoneal
rat
toxic dose : 68 mg/kg/40 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
BJCAAI 36,243,1977
oral
rat
lowest published toxic dose: 3,245 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors
NTPTR* NTP-TR-320,1988
oral
rat
toxic dose : 3,285 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Thyroid tumors
DCTODJ 11,225,1988
oral
rat
lowest published toxic dose: 3,244.5 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors
NTIS** PB89-139760/AS
oral
rat
lowest published toxic dose: 1,369.9 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
NTIS** PB89-139760/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 500 mg/m3/30 minute N/R FRPSAX 20,270,1965
inhalation
rat
lethal concentration (50 percent kill): 20 mg/m3 N/R HBPTO* 2,1183,2001
intramuscular
rabbit
lowest published lethal dose: 5 mg/kg N/R JPETAB 43,193,1931
intraperitoneal
guinea pig
lowest published lethal dose: 10 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
PSEBAA 34,135,1936
intraperitoneal
guinea pig
lowest published lethal dose: 2 mg/kg N/R HBPTO* 1,125,2001
intraperitoneal
mouse
lethal dose (50 percent kill): 1.6 mg/kg N/R HBPTO* 2,1182,2001
intraperitoneal
rat
lethal dose (50 percent kill): 1,600 g/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Cardiac: Pulse rate increased without fall in BP
FRPSAX 20,270,1965
intraperitoneal
rat
lowest published toxic dose: 6 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
BCPCA6 67,2141,2004
intravenous
cat
lowest published lethal dose: 650 g/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting
JPETAB 43,193,1931
intravenous
dog
lowest published lethal dose: 650 g/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting
JPETAB 43,193,1931
intravenous
pigeon
lowest published lethal dose: 1 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting
JPETAB 43,193,1931
intravenous
rat
lethal dose (50 percent kill): 200 g/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Cardiac: Pulse rate increased without fall in BP
FRPSAX 20,270,1965
intravenous
rabbit
lowest published lethal dose: 350 g/kg Behavioral: Ataxia

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory stimulation
JPETAB 43,193,1931
oral
domestic bird
lethal dose (50 percent kill): 850 mg/kg N/R HBPTO* 1,125,2001
oral
wild bird
lethal dose (50 percent kill): 195 mg/kg N/R HBPTO* 1,125,2001
oral
chicken
lethal dose (50 percent kill): 996 mg/kg N/R HBPTO* 1,125,2001
oral
duck
lethal dose (50 percent kill): >2 gm/kg N/R DOEAAH 35,25,1979
oral
dog
lowest published lethal dose: 300 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Nausea or vomiting
JPETAB 43,193,1931
oral
frog
lowest published lethal dose: 4 mg/kg Lung, Thorax, or Respiration: Dyspnea JPETAB 43,193,1931
oral
guinea pig
lowest published lethal dose: 100 mg/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Ulceration or bleeding from stomach
PSEBAA 34,135,1936
oral
guinea pig
lethal dose (50 percent kill): 12 mg/kg N/R HBPTO* 1,125,2001
oral
guinea pig
lowest published lethal dose: 75 mg/kg N/R HBPTO* 1,125,2001
oral
guinea pig
lethal dose (70 percent kill): 60 mg/kg N/R HBPTO* 1,125,2001
oral
human
lowest published lethal dose: 143 mg/kg Gastrointestinal: Other changes 34ZIAG -,521,1969
oral
human
lethal dose (50 percent kill): 300 mg/kg N/R ENTOX* ,744,2005
oral
mouse
lethal dose (50 percent kill): 2,800 g/kg N/R EVHPAZ 14,109,1976
oral
pigeon
lethal dose (50 percent kill): 100 mg/kg N/R HBPTO* 1,125,2001
oral
pig
lowest published lethal dose: 3,700 g/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Nausea or vomiting
JAVMA4 130,410,1957
oral
rat
lethal dose (50 percent kill): 25 mg/kg N/R HBPTO* 1,125,2001
oral
rat
lethal dose (70 percent kill): 600 mg/kg N/R HBPTO* 1,125,2001
oral
rabbit
lowest published lethal dose: 1,600 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Hypermotility, diarrhea
JPETAB 43,193,1931
oral
rabbit
lowest published lethal dose: 1,500 mg/kg N/R HBPTO* 1,125,2001
oral
rabbit
lethal dose (70 percent kill): 3,000 mg/kg N/R HBPTO* 1,125,2001
subcutaneous
guinea pig
lowest published lethal dose: 16 mg/kg N/R HBPTO* 1,125,2001
subcutaneous
rat
lowest published toxic dose: 12 mg/kg Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites EJPHAZ 466,263,2003
subcutaneous
rabbit
lowest published lethal dose: 20 mg/kg N/R JPETAB 43,193,1931
skin
rat
lethal dose (50 percent kill): >940 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit
lethal dose (50 percent kill): >1 gm/kg N/R SPEADM 78-1,5,1978
unreported route
frog
lethal concentration (50 percent kill): 2 ppm N/R HBPTO* 1,125,2001
unreported route
man
lowest published lethal dose: 294 mg/kg N/R 85DCAI 2,73,1970
unreported route
rat
lethal dose (50 percent kill): 132 mg/kg N/R JPFCD2 15,929,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 7.1 mg/kg/42 day- intermittent Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) HBPTO* 1,124,2001
intraperitoneal
rat
lowest published toxic dose: 87.5 mg/kg/5 week- intermittent Behavioral: Rigidity (includes catalepsy) BPBLEO 28,169,2005
oral
dog
lowest published toxic dose: 1,820 mg/kg/26 week- intermittent Behavioral: Food intake (animal) HBPTO* 1,124,2001
oral
dog
lowest published toxic dose: 300 mg/kg/30 day- continuous Liver: Fatty liver degeneration HBPTO* 1,125,2001
oral
hamster
lowest published toxic dose: 180 mg/kg/9 day- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** PB81-190936
oral
mouse
lowest published toxic dose: 54,600 mg/kg/13 week- continuous Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-320,1988
oral
mouse
lowest published toxic dose: 103,824 mg/kg/103 week- intermittent Liver: Tumors

Skin and Appendages: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB89-139760/AS
oral
rat
lowest published toxic dose: 1,505 mg/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-320,1988
oral
rat
lowest published toxic dose: 5,460 mg/kg/13 week- continuous Liver: Changes in liver weight

Blood: Changes in bone marrow not included in above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-320,1988
oral
rat
lowest published toxic dose: 13.5 mg/kg/60 day- intermittent Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) HBPTO* 1,124,2001
oral
rat
lowest published toxic dose: 185 mg/kg/37 day- intermittent Behavioral: Food intake (animal) HBPTO* 1,124,2001
oral
rat
lowest published toxic dose: 746.2 mg/kg/26 week- continuous Behavioral: Food intake (animal) HBPTO* 1,124,2001
subcutaneous
rat
lowest published toxic dose: 84 mg/kg/7 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EJPHAZ 466,263,2003
subcutaneous
rat
lowest published toxic dose: 84 mg/kg/28 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CRTOEC 17,1540,2004
skin
mouse
lowest published toxic dose: 9,130 mg/kg/11 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Liver: Changes in liver weight
TOXID9 60,278,2001
skin
mouse
lowest published toxic dose: 9,130 mg/kg/11 week- intermittent Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in spleen weight

Blood: Eosinophilia
TOXID9 60,278,2001
skin
mouse
lowest published toxic dose: 9,130 mg/kg/11 week- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TOXID9 60,278,2001
skin
mouse
lowest published toxic dose: 21,580 mg/kg/26 week- intermittent Musculoskeletal: Other changes TOXID9 60,278,2001
unreported route
rat
lowest published toxic dose: 70 mg/kg/28 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
FCLPH* 18(Suppl 1),104,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CTRRDO 60,1171,1976
TOXICOLOGY REVIEW
TPHSDY 24,184,2003
TOXICOLOGY REVIEW
TPHSDY 24,395,2003
TOXICOLOGY REVIEW
PHTOEH 93,105,2003
TOXICOLOGY REVIEW
EJPHAZ 545,65,2006
TOXICOLOGY REVIEW
ENTOX* -,744,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 651,1,2008
TOXICOLOGY REVIEW
TOXIA6 49,413,2007
TOXICOLOGY REVIEW
REPTED 23,457,2007
TOXICOLOGY REVIEW
JTPAE7 20,215,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,147,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 DTLVS* 3,224,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ROTENONE-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 67530;
Number of Industries 3;
Total Number of Facilities 70;
Number of Occupations 4;
Total Number of Employees Exposed 2,937
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 67530;
Number of Industries 3;
Total Number of Facilities 913;
Number of Occupations 3;
Total Number of Employees Exposed 8,100;
Total Number of Female Employees Exposed 2,470


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

On EPA IRIS database
NIOSH Analytical Method, 1994: Rotenone, 5007
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
NCI Carcinogenesis Studies (feed);no evidence:mouse
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ.
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a pharmaceutical and veterinary drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product
   Primary Irritant

ALT CAS #: 12679-58-2
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