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Benzene, 1,2,3 - trimethyl -

RTECS #: DC3300000

CAS #: 526-73-8

UPDATE: February 2009 MW: 120.21 MF: C9H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2,3 - Trimethylbenzene
  2. 1,2,3 - Trimethylbenzene (ACGIH)
  1. Hemimellitene
  2. Hemimellitol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 5 µg/plate (-enzymatic activation step) MUREAV 412,299,1998
sister chromatid exchange intraperitoneal
mouse 		730 mg/kg MUREAV 412,299,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published lethal dose: 10 mL/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		AMIHAB 19,403,1959


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 ppm/6 hour/20 day- intermittent Behavioral: Alteration of classical conditioning NRTXDN 22,79,2001
inhalation
rat 		lowest published toxic concentration: 20 mg/m3/16 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition VCVGH* -,176,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 20 ppm (100 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 20 ppm (100 mg/m3), FEB 2006
Occupational Exposure Limit - FRANCE VLE 20 ppm (100 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 100 mg/m3 (20 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 100 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 25 ppm (120 mg/m3), APR2007
Occupational Exposure Limit - MEXICO time-weighted average 25 ppm (125 mg/m3);
short term exposure limit 35 ppm (170 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 100 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 25 ppm (120 mg/m3);
short term exposure limit 35 ppm (170 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (100 mg/m3),KZG- week 40 ppm (200 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (125 mg/m3), 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1997;
Number of Industries 2;
Total Number of Facilities 13;
Number of Occupations 2;
Total Number of Employees Exposed 279


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as raw material in chemical synthesis and as ultraviolet stabilizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as raw material in chemical synthesis and as ultraviolet stabilizer

NIOSH PROFILE (TRIMETHYL BENZENES), SRC, 1/81

RTECS Compound Description:
   Mutagen

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