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Benzene, ethyl -

RTECS #: DA0700000

CAS #: 100-41-4


UPDATE: May 2009 MW: 106.18 MF: C8H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Aethylbenzol (German)
  2. Ethyl benzene
  3. Ethyl benzene (ACGIH:OSHA)
  4. Ethylbenzeen (Dutch)
  5. Ethylbenzene
  1. Ethylbenzol
  2. Etilbenzene (Italian)
  3. Etylobenzen (Polish)
  4. NCI - C56393
  5. Phenylethane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg severe AJOPAA 29,1363,1946
skin
rabbit
15 mg/24 hour open irritation test mild AIHAAP 23,95,1962


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
micronucleus test hamster embryo 25 mg/L MUREAV 392,61,1997
mutation in mammalian somatic cells mouse lymphocyte 80 mg/L EMMUEG 12,85,1988
sister chromatid exchange human lymphocyte 10 mmol/L MUREAV 116,379,1983
specific locus test intraperitoneal
mouse
754 Ámol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 97 ppm/7 hour (15 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) NTIS** PB83-208074
inhalation
rat
lowest published toxic concentration: 985 ppm/7 hour (1-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** PB83-208074
inhalation
rat
lowest published toxic concentration: 96 ppm/7 hour (1-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system NTIS** PB83-208074
inhalation
rat
lowest published toxic concentration: 600 mg/m3/24 hour (7-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ATSUDG 8,425,1985
inhalation
rat
lowest published toxic concentration: 2,400 mg/m3/24 hour (7-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ATSUDG 8,425,1985
inhalation
rat
lowest published toxic concentration: 1,000 ppm (6 hour/6-20 day pregnant) Reproductive: Other developmental abnormalities

Reproductive: Specific developmental abnormalities: Musculoskeletal system
FCTOD7 41,415,2003
inhalation
rat
lowest published toxic concentration: 1,000 ppm (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JAPTO* 27,32,2007
inhalation
rabbit
lowest published toxic concentration: 99 ppm/7 hour (1-18 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** PB83-208074
inhalation
rabbit
lowest published toxic concentration: 500 mg/m3/24 hour (7-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ATSUDG 8,425,1985
inhalation
rabbit
lowest published toxic concentration: 1 gm/m3/24 hour (7-20 day pregnant) Reproductive: Effects on fertility: Abortion ATSUDG 8,425,1985


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 750 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Liver: Tumors
NTPTR* NTP-TR-466,1999
inhalation
mouse
lowest published toxic concentration: 46,350 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTIS** PB99-134694
inhalation
mouse
lowest published toxic concentration: 46,350 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors
NTIS** PB99-134694
inhalation
mouse
lowest published toxic concentration: 750 ppm/1 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TOSCF2 71,53,2003
inhalation
rat
lowest published toxic concentration: 750 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
NTPTR* NTP-TR-466,1999
inhalation
rat
lowest published toxic concentration: 23,400 mg/kg/104 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Reproductive: Tumorigenic effects: Testicular tumors
NTIS** PB99-134694
inhalation
rat
lowest published toxic concentration: 19,500 mg/kg/104 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB99-134694
inhalation
rat
lowest published toxic concentration: 750 ppm/1 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TOSCF2 71,53,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 10,000 ppm Olfaction: Other olfaction effects

Eye: Lacrimation

Behavioral: Tremor
PHRPA6 45,1241,1930
inhalation
guinea pig
lowest published lethal concentration: 2,500 ppm/8 hour Behavioral: Coma NETEEC 24,503,2002
inhalation
human
lowest published toxic concentration: 100 ppm/8 hour Eye: Other eye effects

Behavioral: Sleep

Lung, Thorax, or Respiration: Other changes
AIHAAP 31,206,1970
inhalation
human
lowest published toxic concentration: 21,700 mg/m3 Behavioral: Antipsychotic VCVGH* -,153,1990
inhalation
human
lowest published toxic concentration: 8,700 mg/m3/6 minute Eye: Lacrimation VCVGH* -,153,1990
inhalation
human
lowest published toxic concentration: 4,350 mg/m3 Eye: Conjunctiva irritation

Behavioral: Tolerance
VCVGH* -,153,1990
inhalation
human
lowest published toxic concentration: 4,350 mg/m3 Eye: Conjunctiva irritation VCVGH* -,153,1990
inhalation
human
lowest published toxic concentration: 10 ppm/4 hour Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes
NRTXDN 24,179,2003
inhalation
mouse
lowest published lethal concentration: 50 gm/m3/2 hour N/R GTPZAB 5(5),3,1961
inhalation
mouse
lowest published toxic concentration: 600 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
mouse
lethal concentration (50 percent kill): 35,500 mg/m3/2 hour N/R VCVGH* -,152,1990
inhalation
mouse
lowest published lethal concentration: 10,000 ppm Behavioral: General anesthetic

Behavioral: Ataxia

Nutritional and Gross Metabolic: Body temperature decrease
VCVGH* -,152,1990
inhalation
mouse
lowest published lethal concentration: 5,000 ppm/30 minute N/R VCVGH* -,152,1990
inhalation
rat
lowest published lethal concentration: 4,000 ppm/4 hour N/R AIHAAP 23,95,1962
inhalation
rat
lethal concentration (50 percent kill): 55,000 mg/m3/2 hour N/R VCVGH* -,152,1990
inhalation
rabbit
lethal concentration (50 percent kill): 4,000 ppm/4 hour N/R ENTOX* -,282,2005
intraperitoneal
mouse
lethal dose (50 percent kill): 2,624 ÁL/kg N/R ARTODN 58,106,1985
intraperitoneal
rat
lowest published toxic dose: 1,062 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXAPA9 179,74,2002
oral
rat
lethal dose (50 percent kill): 3,500 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
AMIHAB 14,387,1956
oral
rat
lethal dose (50 percent kill): 3,500 mg/kg N/R VCVGH* -,152,1990
skin
rabbit
lethal dose (50 percent kill): 17,800 ÁL/kg N/R FCTXAV 13,803,1975
skin
rabbit
lethal dose (50 percent kill): >5,000 mg/kg N/R ENTOX* -,282,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 30 mg/m3/7 year- intermittent Behavioral: Headache

Behavioral: Irritability
VCVGH* -,154,1990
inhalation
mouse
lowest published toxic concentration: 975 ppm/6 hour/97 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-92-3129
inhalation
mouse
lowest published toxic concentration: 782 ppm/6 hour/4 week- intermittent Liver: Changes in liver weight FAATDF 13,399,1989
inhalation
rat
lowest published toxic concentration: 740 ppm/6 hour/92 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-92-3129
inhalation
rat
lowest published toxic concentration: 782 ppm/6 hour/4 week- intermittent Liver: Changes in liver weight

Blood: Changes in leukocyte (WBC) count

Blood: Changes in platelet count
FAATDF 13,399,1989
inhalation
rat
lowest published toxic concentration: 550 ppm/8 hour/5 day- intermittent Ear: Change in acuity

Ear: Change in cochlear structure or function
NETEEC 24,503,2002
inhalation
rat
lowest published toxic concentration: 1,000 ppm/6 hour/8 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
FCTOD7 41,415,2003
inhalation
rat
: 1,000 ppm/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 44,1287,2006
inhalation
rat
: 250 ppm/15 day- intermittent Liver: Changes in liver weight FCTOD7 44,1287,2006
inhalation
rat
: 1,000 ppm/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 27,32,2007
inhalation
rat
lowest published toxic dose: 200 ppm/13 week- intermittent Ear: Change in cochlear structure or function ARTODN 81,127,2007
inhalation
rabbit
lowest published toxic concentration: 100 mg/m3/4 hour/30 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes

Blood: Changes in leukocyte (WBC) count
GTPZAB 8(2),9,1964
oral
rat
lowest published toxic dose: 8,993 mg/kg/2 week- intermittent Ear: Change in cochlear structure or function ARTODN 79,346,2005
oral
rabbit
lowest published toxic dose: 1,386 mg/kg/24 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGH* -,154,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm;short term exposure limit 125 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 77,564,2000
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
TOLED5 128,99,2002
TOXICOLOGY REVIEW
TOLED5 140-141,261,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 567,151,2004
TOXICOLOGY REVIEW
ENTOX* -,282,2005
TOXICOLOGY REVIEW
MUREAV 635,81,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 566,49,2004
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (435 mg/m3) DTLVS* 3,104,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (435 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (434 mg/m3), short term exposure limit 125 ppm (543 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (442 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 125 ppm (551 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 50 ppm (217 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 442 mg/m3 (100 ppm);
short term exposure limit 884 mg/m3 (skin), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (435 mg/m3), short term exposure limit 150 ppm (655 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (442 mg/m3), VLE 200 ppm (884 mg/m3), Skin, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 442 mg/m3, short term exposure limit 884 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (217 mg/m3), 2B carcinogen, APR2007
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (217 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 100 ppm (435 mg/m3), short term exposure limit 125 ppm (545 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 100 ppm (435 mg/m3);
short term exposure limit 125 ppm (545 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 215 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 100 ppm (434 mg/m3);
short term exposure limit 125 ppm (543 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (220 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (435 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 350 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 50 mg/m3, short term exposure limit 150 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (200 mg/m3);
short term exposure limit 100 ppm (450 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (435 mg/m3),KZG- week 100 ppm (435 mg/m3),Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (435 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (441 mg/m3);
short term exposure limit 125 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL BENZENE-air 10 hour time-weighted average 100 ppm;
short term exposure limit 125 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 31830;
Number of Industries 64;
Total Number of Facilities 7,190;
Number of Occupations 55;
Total Number of Employees Exposed 57,442
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 31830;
Number of Industries 126;
Total Number of Facilities 17,633;
Number of Occupations 92;
Total Number of Employees Exposed 201,833;
Total Number of Female Employees Exposed 34,405


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/166647)
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in STYRENE manufacture and in synthesis of p-NITROACETOPHENONE
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, aromatic, 1501
NCI Carcinogenesis Studies (inhal);clear evidence:rat
NTP Carcinogenesis Studies (inhalation):some evidence:mouse NTPTR* NTP-TR-475,1998
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse
NTP Toxicity studies, RPT# TOX-10, October 2000
OSHA ANALYTICAL METHOD #1002


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PHRPA6 Public Health Reports. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1878-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in STYRENE manufacture and in synthesis of p-NITROACETOPHENONE

Top 50 chemical production: 10.99 billions lbs in 1992, 8.87 billions in 1991

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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