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Aziridine, 2 - methyl -

RTECS #: CM8050000

CAS #: 75-55-8


UPDATE: May 2009 MW: 57.11 MF: C3H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2 - Propyleneimine
  2. 1,2 - Propylenimine
  3. 2 - Methylazacyclopropane
  4. 2 - Methylaziridine
  5. 2 - Methylethylenimine
  1. Methylethylenimine
  2. Propylene imine
  3. Propylene imine (ACGIH:OSHA)
  4. Propylenimine
  5. RCRA waste number P067


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage hamster lung 300 mol/L/1 hour BBRCA9 72,732,1976
DNA damage intraperitoneal
mouse
40 mg/kg MUREAV 467,83,2000
DNA repair Escherichia coli 2 g/plate JJIND8 62,873,1979
unscheduled DNA synthesis rat liver 10 mg/L MUREAV 97,359,1982
host-mediated assay mouse
Salmonella typhimurium
355 mg/kg JJIND8 62,911,1979
mutation in microorganisms Escherichia coli 10 g/plate (+enzymatic activation step) ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms Salmonella typhimurium 3,300 ng/plate (+/-enzymatic activation step) ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms Schizosaccharomyces pombe 5,470 mol/L (-enzymatic activation step) ADWMAX -,193,1962
micronucleus test intraperitoneal
mouse
10 mg/kg MUREAV 389,3,1997
gene conversion and mitotic recombination Saccharomyes cerevisiae 100 ppm JJIND8 62,901,1979
morphological transform hamster embryo 1 mg/L JJIND8 67,1303,1981
morphological transform mouse fibroblast 80 g/L JJIND8 67,1303,1981
morphological transform rat embryo 15 mg/L JJIND8 67,1303,1981
other mutation test systems Escherichia coli 80 nmol/tube MUREAV 147,79,1985
specific locus test oral
Drosophila melanogaster
1 mmol/L MUREAV 252,305,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,120 mg/kg/28 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Skin and Appendages: Tumors
NATUAS 230,460,1971
oral
rat
toxic dose : 3,920 mg/kg/27 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Skin and Appendages: Tumors
JJIND8 67,75,1981
oral
rat
toxic dose : 4,129 mg/kg/58 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors
JJIND8 67,75,1981


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 500 ppm/1 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
JIHTAB 30,2,1948
inhalation
mouse
lethal concentration : >2 gm/m3/10 minute N/R NDRC** NDCrc-132,Feb,1942
inhalation
rat
lowest published lethal concentration: 500 ppm/4 hour N/R JIHTAB 31,343,1949
intraperitoneal
mouse
lethal dose (50 percent kill): 355 mg/kg N/R JJIND8 62,911,1979
oral
rat
lethal dose (50 percent kill): 19 mg/kg N/R JIHTAB 30,63,1948
skin
guinea pig
lethal dose (50 percent kill): 43 mL/kg N/R JIHTAB 30,63,1948


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 9,61,1975
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1497,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 9,61,1975
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1497,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1497,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 ppm (5 mg/m3) (skin) DTLVS* 3,218,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 ppm (5 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (4.7 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (4.8 mg/m3), Skin, Carcinogen, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (5 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 2 ppm (5 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY ceiling concentration 5 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 2 ppm (4.7 mg/m3), skin, 2B carcinogen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 2 ppm (5 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 2 ppm (5 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.6 g/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 ppm (4.7 mg/m3), skin, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 2 ppm, JUN2003
Occupational Exposure Limit - SWEDEN Group B Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (5 mg/m3), Skin, Carcinogen, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 2 ppm (5 mg/m3), Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYLENE IMINE-air Carcinogen;
10 hour time-weighted average 2 ppm (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 08390;
Number of Industries 1;
Total Number of Facilities 5;
Number of Occupations 2;
Total Number of Employees Exposed 20


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS-human fibroblast; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S pombe-reversion
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-BALB/c-3T3
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the modification of latex surface coating resins
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

ADWMAX Abhandlungen der Deutschen Akademie der Wissenschaften zu Berlin, Klasse fuer Medizin. (Berlin, Ger. Dem. Rep.) 1950-68. Discontinued.
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used in the modification of latex surface coating resins

NIOSH PROFILE (INCINERATION), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen

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