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Aniline, N,N-dimethyl-p-phenylazo-

Related Pages
RTECS #
BX7350000
CAS #
60-11-7
See: NMAM or OSHA Methods
Updated
September 2018
Molecular Weight
225.32
Molecular Formula
C14H15N3
Synonyms
4-(N,N-Dimethylamino)azobenzene
4-(Phenylazo)-N,N-dimethylaniline
4-Dimethylaminoazobenzene (OSHA)
4-Dimethylaminoazobenzol
4-Dimethylaminophenylazobenzene
Atul Fast Yellow R
Azobenzene, p-dimethylamino-
Benzenamine, N,N-dimethyl-4-(phenylazo)- (9CI)
Benzeneazodimethylaniline
Brilliant Fast Oil Yellow
Brilliant Fast Spirit Yellow
Brilliant Fast Yellow
Brilliant Oil Yellow
Butter Yellow
C.I. 11020
C.I. Solvent Yellow 2
Cerasine Yellow GG
DAB
DAB (carcinogen)
Dimethyl Yellow
Dimethyl Yellow Analar
Dimethyl Yellow N,N-dimethylaniline
DMAB
Enial Yellow 2G
Fast Oil Yellow B
Fast Yellow
Fat Yellow
Fat Yellow A
Fat Yellow AD OO
Fat Yellow ES
Fat Yellow ES Extra
Fat Yellow Extra Conc.
Fat Yellow R
Fat Yellow R (8186)
Grasal Brilliant Yellow
Iketon Yellow Extra
Jaune de beurre (French)
Methyl Yellow
N,N-Dimethyl-4-(phenylazo)benzamine
N,N-Dimethyl-4-(phenylazo)benzenamine
N,N-Dimethyl-4-aminoazobenzene
N,N-Dimethyl-p-aminoazobenzene
N,N-Dimethyl-p-azoaniline
N,N-Dimethyl-p-phenylazoaniline
Oil Yellow 20
Oil Yellow 2625
Oil Yellow 2G
Oil Yellow 7463
Oil Yellow BB
Oil Yellow D
Oil Yellow DN
Oil Yellow FF
Oil Yellow FN
Oil Yellow G
Oil Yellow G-2
Oil Yellow GG
Oil Yellow GR
Oil Yellow II
Oil Yellow N
Oil Yellow PEL
Oil Yellow S
Oleal Yellow 2G
Organol Yellow ADM
Orient Oil Yellow GG
P.D.A.B.
p-Dimethylaminoazobenzen (Czech)
p-Dimethylaminoazobenzene
p-Dimethylamino-azobenzol (German)
Petrol Yellow WT
RCRA waste number U093
Resinol Yellow GR
Resoform Yellow GGA
Silotras Yellow T2G
Somalia Yellow A
Stear Yellow JB
Sudan GG
Sudan Yellow
Sudan Yellow GG
Sudan Yellow GGA
Toyo Oil Yellow G
USAF EK-338
Waxoline Yellow AD
Waxoline Yellow ADS
Yellow G soluble in grease
Zlut maselna (Czech)
Zlut rozpoustedlova 2 (Czech)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/rat600 mg/kgNATUAS 249,850,1974
Cytogenetic Analysisoral/rat756 mg/kg/3WJNCIAM 54,1245,1975
Cytogenetic Analysisoral/mouse4950 mg/kg/30D- intermittentMUREAV 587,1,2005
Cytogenetic Analysisoral/mouse4950 mg/kg/30D-continuousFCTOD7 46,1474,2008
DNA adductoral/rat300 mg/kgCNREA8 36,4647,1976
DNA adductintraperitoneal/rat150 mg/kgNATUAS 213,1206,1967
DNA adductintraperitoneal/mouse120 mg/kgCNREA8 40,2493,1980
DNA adductskin/mouse192 µmol/kgCRNGDP 5,231,1984
DNA Damageintraperitoneal/mouse200 mg/kgMUREAV 493,39,2001
DNA Damageoral/mouse500 mg/kgMUREAV 493,39,2001
DNA inhibitionintraperitoneal/mouse20 gm/kgARGEAR 51,605,1981
DNA inhibitionoral/mouse100 mg/kgMUREAV 46,305,1977
DNA inhibitionHeLa cell/human100 µmol/LMUREAV 92,427,1982
DNA repair/Escherichia coli80 mg/LMUREAV 119,135,1983
DNA repair/Saccharomyes cerevisiae600 mg/LPMRSDJ 1,502,1981
gene conversion and mitotic recombination/Saccharomyes cerevisiae5 mg/LPMRSDJ 1,491,1981
gene conversion and mitotic recombinationoral/Drosophila melanogaster2.0 mmol/L/48HMUTAEX 16,385,2001
host-mediated assaySalmonella typhimurium/mouse255 mg/kg/3HMUREAV 45,291,1977
micronucleus testintraperitoneal/mouse6400 µg/kgPMRSDJ 1,686,1981
micronucleus testoral/mouse1155 mg/kg/7D-continuousFCTOD7 46,1474,2008
micronucleus testoral/rat150 mg/kg/2D- intermittentMUREAV 698,24,2010
micronucleus testoral/mouse9900 mg/kg/60D- intermittentMUREAV 587,1,2005
micronucleus testintraperitoneal/rat71 mg/kgMUREAV 583,133,2005
micronucleus testoral/rat120 mg/kgMUREAV 583,133,2005
micronucleus testoral/rat700 mg/kg/14DMUREAV 780-781,2,2015
morphological transformembryo/rat12 mg/LJJIND8 67,1303,1981
morphological transformembryo/mouse89 µmol/LMUREAV 152,113,1985
morphological transformother cell types/non-mammalian species250 µg/LAOHYA3 20,297,1977
morphological transformfibroblast/mouse1 mg/L/21D (-enzymatic activation step)EMMUEG 35,300,2000
morphological transformintraperitoneal/hamster500 mg/kgARPAAQ 95,380,1973
morphological transformembryo/hamster50 µg/LJJIND8 67,1303,1981
morphological transformkidney/hamster25 mg/LPMRSDJ 1,638,1981
mutation in mammalian somatic cellslymphocyte/mouse89 µmol/LMUREAV 110,147,1983
mutation in microorganismslymphocyte/mouse6250 µg/L (+enzymatic activation step)EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms/Salmonella typhimurium5 mg/plate (+enzymatic activation step)AEMIDF 42,641,1981
mutation in microorganisms/Salmonella typhimurium33 µg/plate (-enzymatic activation step)ENMUDM 9(Suppl 9),1,1987
mutation in microorganisms/Escherichia coli200 mg/L (+enzymatic activation step)PMRSDJ 1,396,1981
other mutation test systemsintraperitoneal/mouse100 mg/kgMUREAV 747,164,2012
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae50 mg/LPMRSDJ 1,468,1981
sister chromatid exchangeintraperitoneal/mouse29 mg/kgMUREAV 108,225,1983
specific locus testother cell types/human50 mg/L/3H (+enzymatic activation step)MUTAEX 24,35,2009
sperm morphologyoral/mouse9900 mg/kg/60D-continuousFCTOD7 46,1474,2008
sperm morphologyintraperitoneal/mouse3 gm/kg/5D- intermittentPMRSDJ 1,712,1981
Unscheduled DNA Synthesisliver/mouse1 µmol/LGANNA2 72,930,1981
Unscheduled DNA Synthesisliver/hamster1 µmol/LENMUDM 5,1,1983
Unscheduled DNA SynthesisHeLa cell/human10 nmol/LCNREA8 38,2621,1978
Unscheduled DNA Synthesisfibroblast/human4 mg/LPMRSDJ 1,528,1981
Unscheduled DNA Synthesisliver/rat1 µmol/LCNREA8 46,1654,1986
Unscheduled DNA Synthesisliver/rat1 µmol/LJJCREP 78,505,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 3 gm/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)PMRSDJ 1,712,1981
subcutaneous/mouse 200 mg/kg (10D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemOFAJAE 36,195,1960

Tumorigenic Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 3830 µg/kgTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		CNREA8 44,2540,1984
intraperitoneal/mouse toxic dose: 11 mg/kgTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		CNREA8 44,2540,1984
multiple/mouse lowest published toxic dose: 400 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Tumors at site of application		CNREA8 1,397,1941
oral/Dog lowest published toxic dose: 9600 mg/kg/69W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors		JNCIAM 13,1497,1953
oral/hamster lowest published toxic dose: 9600 mg/kg/42W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Change in gall bladder structure or function

Blood: Other hemolysis with or without anemia		ARPAAQ 71,566,1961
oral/mouse lowest published toxic dose: 9900 mg/kg/60D- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		FCTOD7 46,1474,2008
oral/rat lowest published toxic dose: 3.24 gm/kg/90D- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		FCTOD7 48,3281,2010
oral/rat toxic dose: 800 mg/kg/64D- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		ZEKBAI 61,327,1956
oral/rat lowest published toxic dose: 5426 mg/kg/17W- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors		CBINA8 53,107,1985
oral/rat toxic dose: 2600 mg/kg/13W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		CNREA8 17,387,1957
oral/rat toxic dose: 13 gm/kg/53W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		MEXPAG 4,1,1961
oral/rat toxic dose: 1920 mg/kg/14W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		CNREA8 5,235,1945
oral/rat toxic dose: 1800 mg/kg/14W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		CNREA8 8,141,1948
oral/rat toxic dose: 2331 mg/kg/7W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors		KTUNAA 32,229,1979
oral/rat toxic dose: 17200 mg/kg/17W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		ARPAAQ 81,162,1966
oral/rat toxic dose: 8316 mg/kg/33W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors		JPBAA7 59,1,1947
oral/rat toxic dose: 3990 mg/kg/19W- continuousTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Consolidation

Liver: Tumors		GANNA2 63,131,1972
skin/rat lowest published toxic dose: 1440 mg/kg/90W- intermittentTumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors		CNREA8 26,2406,1966
subcutaneous/mouse lowest published toxic dose: 4000 mg/kg (15-21D pregnant)Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors		BEXBAN 78,1402,1974

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 230 mg/kgLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis		CNREA8 34,2274,1974
intraperitoneal/mouse lethal dose (50 percent kill): 230 mg/kgENTOX* -,356,2005
intraperitoneal/mouse lowest published lethal dose: 230 mg/kgMUREAV 747,164,2012
intraperitoneal/rat lethal dose (50 percent kill): 230 mg/kgLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis		CNREA8 34,2274,1974
intraperitoneal/rat lethal dose (50 percent kill): 230 mg/kgENTOX* -,356,2005
oral/mouse lethal dose (50 percent kill): 300 mg/kgENTOX* -,53,2005
oral/rat lethal dose (50 percent kill): 200 mg/kgENTOX* -,53,2005

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 20000 mg/kg/40D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects		BJCAAI 86,630,2002
oral/mouse lowest published toxic dose: 9900 mg/kg/60D- intermittentLiver: Tumors

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)		MUREAV 587,1,2005
oral/mouse lowest published toxic dose: 1155 mg/kg/7D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases		MUREAV 587,1,2005
oral/mouse lowest published toxic dose: 1155 mg/kg/7D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen		FCTOD7 46,1474,2008
oral/mouse lowest published toxic dose: 1.75 mg/kg/5W- intermittentLiver: Other changes

Nutritional and Gross Metabolic: Changes in: Other metals

Biochemical: Metabolism (intermediary): Other		TOLED5 203,40,2011
oral/rat lowest published toxic dose: 1400 mg/kg/14D- intermittentLiver: Tumors

Liver: Changes in liver weight		MUREAV 780-781,2,2015

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 8,125,1975
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 8,125,1975
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMSUDL 7,56,1987
TOXICOLOGY REVIEWALLVAR 50,77,1962
TOXICOLOGY REVIEWBJCAAI 6,270,1952
TOXICOLOGY REVIEWADCSAJ 13,271,1970
TOXICOLOGY REVIEWJONUAI 44,345,1951
TOXICOLOGY REVIEWBLFSBY 24,129,1983
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUREAV 578,88,2005
TOXICOLOGY REVIEWENTOX* -,356,2005
TOXICOLOGY REVIEWMUREAV 627,10,2007
TOXICOLOGY REVIEWENTOX* -,53,2005
TOXICOLOGY REVIEWENTOX* -,104,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUREAV 681,51,2009
TOXICOLOGY REVIEWMUTAEX 26,223,2011
TOXICOLOGY REVIEWMUREAV 733,4,2012
TOXICOLOGY REVIEWMUREAV 769,34,2014
TOXICOLOGY REVIEWMUREAV 802,1,2016
TOXICOLOGY REVIEWFCTOD7 106,609,2017

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012
Occupational Exposure Limit-SWEDENGroup A Carcinogen, JUN2005
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)see Code of Federal Regulations (CFR) 29,1926.1115CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA)-cancer suspect agentCFRGBR 29,1910.1015,1987

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 4-DIMETHYLAMINOAZOBENZENE-airCarcinogen use 29 Code of Federal Regulations (CFR) 1910.1015NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 26175; Number of Industries 2; Total Number of Facilities 56; Number of Occupations 2; Total Number of Employees Exposed 1453; Total Number of Female Employees Exposed 996
National Occupational Hazard Survey 1974Hazard Code 26175; Number of Industries 2; Total Number of Facilities 29; Number of Occupations 2; Total Number of Employees Exposed 42

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: SHE-clonal assay; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Mammalian micronucleus; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
On EPA IRIS database
Page last reviewed: November 16, 2018
Content source: National Institute for Occupational Safety and Health