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Aniline, N,N - dimethyl -

RTECS #: BX4725000

CAS #: 121-69-7


UPDATE: May 2009 MW: 121.20 MF: C8H11N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. (Dimethylamino) benzene
  2. Benzenamine, N,N - dimethyl -
  3. Dimethylaniline
  4. Dimethylaniline (ACGIH:OSHA)
  5. Dwumetyloanilina (Polish)
  6. N,N - Dimethylaniline
  1. N,N - Dimethylaniline (OSHA)
  2. N,N - Dimethylbenzenamine
  3. N,N - Dimethylphenylamine
  4. NCI - C56428
  5. NL 63 - 10P
  6. Versneller NL 63/10


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
20 mg/24 hour moderate 85JCAE -,461,1986
skin
rabbit
10 mg/24 hour open irritation test mild AIHAAP 23,95,1962
skin
rabbit
500 mg/24 hour mild 85JCAE -,461,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 83 mg/L EMMUEG 13,60,1989
DNA damage intraperitoneal
mouse
485 mg/kg EMMUEG 21,349,1993
DNA damage intraperitoneal
rat
485 mg/kg EMMUEG 21,349,1993
micronucleus test hamster lung 900 mol/L EMMUEG 21,349,1993
mutation in mammalian somatic cells mouse lymphocyte 20 mg/L NTPTR* NTP-TR-360,1989
sister chromatid exchange hamster ovary 30 mg/L EMMUEG 13,60,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 15,450 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors
NTPTR* NTP-TR-360,1989
oral
mouse
lowest published toxic dose: 15,450 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB90-227240/AS
oral
rat
lowest published toxic dose: 15,450 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors
NTPTR* NTP-TR-360,1989
oral
rat
lowest published toxic dose: 15,450 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
NTIS** PB90-227240/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 250 mg/m3/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement
GISAAA 37(4),35,1972
oral
human
lowest published lethal dose: 50 mg/kg Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes
NCPBBY Jan/Feb,1969
oral
mouse
lowest published lethal dose: 350 mg/kg N/R NTPTR* NTP-TR-360,1989
oral
rat
lethal dose (50 percent kill): 951 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis
NTIS** OTS0571982
subcutaneous
rat
lowest published lethal dose: 100 mg/kg N/R 85GMAT -,55,1982
skin
guinea pig
lethal dose (50 percent kill): >20 mL/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0571982
skin
rabbit
lethal dose (50 percent kill): 1,770 L/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 10,700 g/m3/5 hour/17 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 37(4),35,1972
inhalation
rat
lowest published toxic concentration: 300 g/m3/24 hour/14 week- continuous Behavioral: Muscle contraction or spasticity

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count
GISAAA 34(3),7,1969
oral
mouse
lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Blood: Changes in spleen JTEHD6 29,77,1990
oral
mouse
lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
NTPTR* NTP-TR-360,1989
oral
rat
lowest published toxic dose: 32,500 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTEHD6 29,77,1990
oral
rat
lowest published toxic dose: 16,250 mg/kg/13 week- intermittent Liver: Other changes

Blood: Changes in bone marrow not included in above

Blood: Changes in spleen
NTPTR* NTP-TR-360,1989
oral
rat
lowest published toxic dose: 2 gm/kg/2 day- intermittent Behavioral: Food intake (animal)

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0571982
oral
rat
lowest published toxic dose: 1,100 mg/kg/15 day- intermittent Endocrine: Changes in spleen weight NTIS** OTS0571982
oral
rat
lowest published toxic dose: 1,545 mg/kg/103 week- intermittent Blood: Leukemia

Tumorigenic: Active as anti-cancer agent
NTIS** PB90-227240/AS


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm;short term exposure limit 10 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 57,337,1993
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 57,337,1993
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 57,337,1993
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (25 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (25 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 10 ppm (51 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (25 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 5 ppm (25 mg/m3), Skin, continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - GERMANY MAK 25 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 25 mg/m3, short term exposure limit 100 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 ppm (25 mg/m3), skin, APR2007
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (25 mg/m3), short term exposure limit 10 ppm (50 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (25 mg/m3);
short term exposure limit 10 ppm (50 mg/m3) (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (25 mg/m3);
short term exposure limit 10 ppm (50 mg/m3), skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (25 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (25 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 40 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.2 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (5 mg/m3);
short term exposure limit 2 ppm (10 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (25 mg/m3);
KZG- week 10 ppm (50 mg/m3), Skin, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (25 mg/m3);
short term exposure limit 10 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIMETHYLANILINE-air 10 hour time-weighted average 5 ppm (Sk);
short term exposure limit 10 ppm (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 26335;
Number of Industries 4;
Total Number of Facilities 100;
Number of Occupations 10;
Total Number of Employees Exposed 2,456
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 26335;
Number of Industries 15;
Total Number of Facilities 1,428;
Number of Occupations 27;
Total Number of Employees Exposed 30,480;
Total Number of Female Employees Exposed 7,448


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate, solvent, emulsifier and laboratory reagent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Amines, aromatic, 2002
NTP Carcinogenesis Studies (gavage);some evidence:rat NTPTR* NTP-TR-360,1989
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCPBBY National Clearinghouse for Poison Control Centers, Bulletin. (U.S. Department of Health, Education, and Welfare, Washington, DC)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

Used as a chemical intermediate, solvent, emulsifier and laboratory reagent

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 162744-63-0
ALT CAS #: 168153-21-7
ALT CAS #: 171745-67-8
Click Here for Additional Information about RTECS

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