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Acrolein

RTECS #: AS1050000

CAS #: 107-02-8


UPDATE: May 2009 MW: 56.07 MF: C3H4O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Propenal
  2. Acraldehyde
  3. Acraldehydeacroleina (Italian)
  4. Acroleina (Italian)
  5. Acrolein (ACGIH:OSHA)
  6. Acroleine (Dutch, French)
  7. Acrylaldehyde
  8. Acrylaldehyd (German)
  9. Acrylic aldehyde
  10. Akrolein (Czech)
  11. Akroleina (Polish)
  12. Aldehyde acrylique (French)
  13. Aldeide acrilica (Italian)
  14. Allyl aldehyde
  1. Aqualin
  2. Aqualine
  3. Biocide
  4. Crolean
  5. Ethylene aldehyde
  6. Magnacide B
  7. Magnacide H
  8. Magnacide
  9. NSC 8819
  10. Prop - 2 - en - 1 - al
  11. RCRA waste number P003
  12. Slimicide
  13. trans - Acrolein


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
500 ppb/12 minute N/R IAPWAR 4,79,1961
eye
rabbit
1 mg severe UCDS** 6/18/1971
eye
rabbit
50 g/24 hour severe 85JCAE -,268,1986
skin
human
1% VCVGK* -,386,1994
skin
rabbit
5 mg open irritation test severe UCDS** 6/18/1971
skin
rabbit
2 mg/24 hour severe 85JCAE -,268,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA adduct Escherichia coli 286 nmol/L ARTODN 46,277,1980
DNA adduct human fibroblast 100 mol/L CRNGDP 12,1483,1991
DNA adduct mammal (species unspecified) lymphocyte 58 gm/L/3 hour CNREA8 44,990,1984
DNA damage hamster lung 20 nmol/L/18 hour TOLED5 148,65,2004
DNA damage human other cell types 30 mol/L CNREA8 48,1717,1988
DNA damage human lung 0.15 pmol/well/1 hour TOLED5 132,27,2002
DNA damage rat other cell types 30 mmol/L ARTODN 58,67,1985
DNA inhibition mammal (species unspecified) lymphocyte 80 mol/L FEBLAL 30,286,1973
DNA inhibition intraperitoneal
rat
500 g/kg BICMBE 53,243,1971
mutation in microorganisms Escherichia coli 320 nmol/plate MUREAV 516,81,2002
mutation in microorganisms Salmonella typhimurium 50 g/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 50 g/plate (-enzymatic activation step) NTPTB* JAN1982
mutation in mammalian somatic cells hamster lung 500 nmol/L CRNGDP 11,497,1990
mutation in mammalian somatic cells human fibroblast 200 nmol/L MUREAV 209,17,1988
other mutation test systems intraperitoneal
rat
500 g/kg BICMBE 53,243,1971
sister chromatid exchange hamster ovary 10 mol/L CGCGBR 26,108,1980
sister chromatid exchange unreported route
hamster
1.5 mg/kg VCVGK* -,385,1994
sister chromatid exchange human lymphocyte 5 mol/L CNREA8 46,203,1986
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
3 mmol/L MUREAV 260,247,1991
specific locus test oral
Drosophila melanogaster
5 mmol/L MUREAV 260,247,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
rabbit
lowest published toxic dose: 6 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ARZNAD 30,2080,1980
oral
rat
lowest published toxic dose: 840 mg/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FAATDF 19,228,1992


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 1,570 mg/m3/2 hour N/R APTOA6 6,299,1950
inhalation
cat
lowest published toxic concentration: 250 mg/m3 Eye: Lacrimation

Behavioral: General anesthetic

Gastrointestinal: Changes in structure or function of salivary glands
VCVGK* -,383,1984
inhalation
cat
lowest published toxic concentration: 200 mg/m3 Lung, Thorax, or Respiration: Other changes VCVGK* -,383,1984
inhalation
cat
lowest published lethal concentration: 1,500 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,383,1984
inhalation
child
lowest published toxic concentration: 300 ppb/2 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Other changes
NPMDAD 8,2469,1979
inhalation
guinea pig
lowest published lethal concentration: 24 mg/m3/6 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema
BMJOAE 2,913,1956
inhalation
guinea pig
lethal concentration (50 percent kill): 10.5 ppm/6 hour Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,383,1984
inhalation
hamster
lowest published lethal concentration: 1,000 ppm/10 minute Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands
SAIGBL 19,367,1977
inhalation
hamster
lethal concentration (50 percent kill): 25.4 ppm/4 hour N/R VCVGK* -,383,1984
inhalation
human
lowest published lethal concentration: 5,500 ppb N/R 34ZIAG -,73,1969
inhalation
human
lowest published lethal concentration: 153 ppm/10 minute N/R NTIS** PB214-270
inhalation
human
lowest published lethal concentration: 350 mg/m3/10 minute N/R VCVGK* -,384,1984
inhalation
human
lowest published toxic concentration: 7 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,384,1984
inhalation
human
lowest published toxic concentration: 2 mg/m3/2 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,384,1984
inhalation
human
lowest published toxic concentration: 0.6 mg/m3/5 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,384,1984
inhalation
human
lowest published toxic concentration: 0.8 ppm Lung, Thorax, or Respiration: Dyspnea VCVGK* -,384,1984
inhalation
human
lowest published toxic concentration: 0.3 ppm Lung, Thorax, or Respiration: Cough VCVGK* -,384,1984
inhalation
human
lowest published toxic concentration: 0.14 ppm/2 minute Eye: Conjunctiva irritation VCVGK* -,384,1984
inhalation
man
lowest published toxic concentration: 1 ppm Eye: Lacrimation BMJOAE 2,913,1956
inhalation
mouse
lethal concentration (50 percent kill): 66 ppm/6 hour N/R IAANBS 26,281,1970
inhalation
mouse
lethal concentration (50 percent kill): 875 ppm/1 minute Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,383,1984
inhalation
mouse
lethal concentration (50 percent kill): 175 ppm/10 minute Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,383,1984
inhalation
mouse
lethal concentration (50 percent kill): 152 mg/m3/6 hour Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,383,1984
inhalation
mouse
lowest published lethal concentration: 200 mg/m3 N/R VCVGK* -,383,1984
inhalation
mouse
lowest published lethal concentration: 650 mg/m3 Lung, Thorax, or Respiration: Other changes VCVGK* -,383,1984
inhalation
mouse
lowest published toxic concentration: 1.7 ppm/10 minute Lung, Thorax, or Respiration: Respiratory depression VCVGK* -,383,1984
inhalation
mouse
lowest published toxic concentration: 1.1 ppm Olfaction: Other olfaction effects TOXID9 66,98,2002
inhalation
rat
lethal concentration (50 percent kill): 18 mg/m3/4 hour N/R CUTOEX 1,47,1993
inhalation
rat
lethal concentration (50 percent kill): 131 ppm/30 minute Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,383,1984
inhalation
rat
lethal concentration (50 percent kill): 8 ppm/4 hour Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,383,1984
inhalation
rat
lowest published toxic concentration: 23 ppm Lung, Thorax, or Respiration: Respiratory depression VCVGK* -,383,1984
inhalation
rat
lowest published toxic concentration: 2.5 ppm/4 hour Vascular: Other changes VCVGK* -,383,1984
inhalation
rabbit
lowest published lethal concentration: 24 mg/m3/6 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema
BMJOAE 2,913,1956
inhalation
rabbit
lethal concentration (50 percent kill): 10.5 ppm/6 hour N/R VCVGK* -,383,1984
intraperitoneal
mouse
lethal dose (50 percent kill): 9,008 g/kg N/R NCISP* JAN1986
intraperitoneal
rat
lethal dose (50 percent kill): 4 mg/kg N/R TXAPA9 71,84,1983
intravenous
cat
lowest published lethal dose: 15 mg/kg Blood: Other changes APTOA6 8,275,1952
intravenous
rat
lowest published toxic dose: 3 mg/kg Gastrointestinal: Other changes

Blood: Changes in other cell count (unspecified)
VCVGK* -,384,1984
intravenous
rat
lowest published toxic dose: 0.5 mg/kg Vascular: BP lowering not characterized in autonomic section VCVGK* -,384,1984
intravenous
rat
lowest published toxic dose: 0.5 mg/kg Vascular: BP elevation not characterized in autonomic section VCVGK* -,384,1984
oral
human
lowest published lethal dose: 140 mg/kg N/R VCVGK* -,384,1984
oral
mammal (species unspecified)
lowest published lethal dose: 10 mg/kg N/R AJHYA2 29,32,1939
oral
mouse
lethal dose (50 percent kill): 13,900 g/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0533812
oral
mouse
lethal dose (50 percent kill): 28 mg/kg N/R VCVGK* -,383,1984
oral
mouse
lowest published toxic dose: 5 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 44,377,2005
oral
mouse
lowest published toxic dose: 5 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
TOXID9 90,105,2006
oral
mouse
lowest published lethal dose: 8 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
TOXID9 90,105,2006
oral
mouse
lowest published toxic dose: 5 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 -,169,2008
oral
rat
lethal dose (50 percent kill): 26 mg/kg N/R GISAAA 58(10),4,1993
oral
rabbit
lethal dose (50 percent kill): 7 mg/kg N/R ENTOX* -,40,2005
subcutaneous
guinea pig
lowest published lethal dose: 178 g/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea
AEXPBL 43,351,1900
subcutaneous
mouse
lethal dose (50 percent kill): 30 mg/kg Behavioral: General anesthetic

Liver: Fatty liver degeneration
APTOA6 6,299,1950
subcutaneous
mouse
lowest published lethal dose: 400 mg/kg Behavioral: Excitement

Vascular: Shock
VCVGK* -,383,1984
subcutaneous
rat
lethal dose (50 percent kill): 50 mg/kg Behavioral: General anesthetic

Liver: Fatty liver degeneration
APTOA6 6,299,1950
subcutaneous
rabbit
lowest published lethal dose: 250 mg/kg Lung, Thorax, or Respiration: Dyspnea AEXPBL 43,351,1900
subcutaneous
rabbit
lethal dose (50 percent kill): 164 mg/kg N/R VCVGK* -,383,1984
skin
rabbit
lethal dose (50 percent kill): 160 mg/kg N/R ENTOX* -,40,2005
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 45 mg/kg N/R 30ZDA9 -,111,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 3,700 ppb/8 hour/6 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi TXAPA9 17,726,1970
inhalation
hamster
lowest published toxic concentration: 4,900 ppb/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
TXCYAC 9,47,1978
inhalation
hamster
lowest published toxic concentration: 4 ppm/7 hour/52 week- intermittent Brain and Coverings: Changes in brain weight

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight
JTEHD6 3,379,1977
inhalation
hamster
lowest published toxic concentration: 4.9 ppm/13 week- intermittent Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count
VCVGK* -,385,1994
inhalation
monkey
lowest published toxic concentration: 3,700 ppb/8 hour/6 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 17,726,1970
inhalation
mouse
lowest published toxic concentration: 6 ppm/6 hour/2 week- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGK* -,384,1994
inhalation
mouse
lowest published toxic concentration: 25 ppm/6 hour/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,384,1994
inhalation
rat
lowest published toxic concentration: 4 ppm/6 hour/62 day- intermittent Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXCYAC 34,139,1985
inhalation
rat
lowest published toxic concentration: 4,900 ppb/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Endocrine: Changes in adrenal weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXCYAC 9,47,1978
inhalation
rat
lowest published toxic concentration: 510 g/m3/24 hour/9 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GISAAA 31(1),9,1966
inhalation
rat
lowest published toxic concentration: 3 ppm/6 hour/3 week- intermittent Olfaction: Other olfaction effects

Endocrine: Changes in spleen weight
TOLED5 39,189,1987
inhalation
rat
lowest published toxic concentration: 1.52 ppm/61 day- continuous Lung, Thorax, or Respiration: Other changes VCVGK* -,384,1994
inhalation
rat
lowest published toxic concentration: 0.51 ppm/61 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi VCVGK* -,384,1994
inhalation
rat
lowest published toxic concentration: 0.55 ppm/10 day- continuous Lung, Thorax, or Respiration: Cough

Immunological Including Allergic: Decreased immune response
VCVGK* -,384,1994
inhalation
rat
lowest published toxic concentration: 4 ppm/6 hour/62 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,385,1994
inhalation
rat
lowest published toxic concentration: 1.4 ppm/6 hour/62 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes
VCVGK* -,385,1994
inhalation
rat
lowest published toxic concentration: 1.52 mg/m3/60 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,385,1994
inhalation
rat
lowest published toxic concentration: 0.51 mg/m3/60 day- continuous Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
VCVGK* -,385,1994
inhalation
rat
lowest published toxic concentration: 0.15 mg/m3/60 day- continuous Blood: Changes in leukocyte (WBC) count VCVGK* -,385,1994
inhalation
rabbit
lowest published toxic concentration: 4,900 ppb/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
TXCYAC 9,47,1978
intratracheal
chicken
lowest published toxic dose: 200 ppm/5 minute/3 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi VCVGK* -,385,1994
oral
rat
lowest published toxic dose: 113 mg/kg/45 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
IJEBA6 35,1373,1997
oral
rat
lowest published toxic dose: 91 mg/kg/26 week- intermittent Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,385,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.1 ppm (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 19,479,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 36,133,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 36,133,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 63,337,1995
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,78,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 63,339,1995
TOXICOLOGY REVIEW
EVHPAZ 11,163,1975
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
MUREAV 47,115,1978
TOXICOLOGY REVIEW
MUREAV 544,115,2003
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
ENTOX* -,40,2005
TOXICOLOGY REVIEW
DIMON* 46,551,2000
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 531,1,2003
TOXICOLOGY REVIEW
MUTAEX 19,169,2004
TOXICOLOGY REVIEW
REPTED 23,428,2007
TOXICOLOGY REVIEW
MUREAV 659,56,2008
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,159,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.25 mg/m3) DTLVS* 3,5,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.25 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.25 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.25 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.25 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (0.25 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.23 mg/m3), short term exposure limit 0.3 ppm, (0.69 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRIA MAK 0.25 mg/m3 (0.1 ppm), JAN 2006
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.23 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.3 ppm (0.7 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.05 ppm (0.12 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.25 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VLE 0.1 ppm (0.25 mg/m3), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.23 mg/m3, short term exposure limit 0.23 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (0.23 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.25 mg/m3), short term exposure limit 0.3 ppm (0.8 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (0.25 mg/m3);
short term exposure limit 0.3 ppm (0.8 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.23 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.25 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.25 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.2 mg/m3, MAC(short term exposure limit) 0.5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.2 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 ppm (0.2 mg/m3);
short term exposure limit 0.3 ppm (0.7 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.25 mg/m3),KZG- week 0.1 ppm (0.25 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.25 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.23 mg/m3);
short term exposure limit 0.3 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACROLEIN-air 10 hour time-weighted average 0.1 ppm;
short term exposure limit 0.3 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 03530;
Number of Industries 16;
Total Number of Facilities 845;
Number of Occupations 25;
Total Number of Employees Exposed 7,299
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 03530;
Number of Industries 4;
Total Number of Facilities 37;
Number of Occupations 18;
Total Number of Employees Exposed 1,298;
Total Number of Female Employees Exposed 5


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180307/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as pharmaceutical and slimicide and in production of cosmetics and food supplements
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
NIOSH Analytical Method, 1994: Acrolein, 2501
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
NTP Carcinogenesis studies; test completed (peer review), October 2000
OSHA ANALYTICAL METHOD #52


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64. For publisher information, see AJEPAS.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CGCGBR Cytogenetics and Cell Genetics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.12- 1973-
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEBLAL FEBS Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1968-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTOX*
IAANBS Internationales Archiv fuer Arbeitsmedizin. (Berlin, Ger.) V.26-34, 1970-75. For publisher information, see IAEHDW.
IAPWAR International Journal of Air and Water Pollution. (London, UK) V.4(1-4), 1961. For publisher information, see ATENBP.
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPMDAD Nouvelle Presse Medicale. (Paris, France) V.1-11, 1972-82.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTB* NTP Technical Bulletin. (National Toxicology Program, Landow Bldg. 3A-06, 7910 Woodmont Ave., Bethesda, MD 20205)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as pharmaceutical and slimicide and in production of cosmetics and food supplements

NIOSH PROFILE (ACROLEIN), SRC, 12/79

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

NIOSH PROFILE (INCINERATION), FIRL, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 25314-61-8
Click Here for Additional Information about RTECS

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