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Acetylene, dichloro -

RTECS #: AP1080000

CAS #: 7572-29-4


UPDATE: May 2009 MW: 94.92 MF: C2Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Dichloroacetylene
  2. Dichloroacetylene (ACGIH:OSHA)
  1. Dichloroethyne
  2. Ethyne, dichloro - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 4,000 ppm (+/-enzymatic activation step) MUREAV 117,21,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 2 ppm/24 hour/77 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Blood: Tumors
CRNGDP 5,1411,1984
inhalation
rat
lowest published toxic concentration: 14 ppm/6 hour/77 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Vascular: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
CRNGDP 5,1411,1984


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 19 ppm/6 hour Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
FCTXAV 13,511,1975
inhalation
mouse
lethal concentration (50 percent kill): 480 mg/m3/1 hour N/R VCVGH* -,530,1990
inhalation
mouse
lethal concentration (50 percent kill): 74 mg/m3/6 hour Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
VCVGH* -,530,1990
inhalation
rabbit
lowest published lethal concentration: 307 ppm/1 hour Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
FCTXAV 16,227,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
rat
lowest published toxic dose: 850 mg/kg/10 week- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Biochemical: Metabolism (intermediary): Lipids including transport
NRTXDN 13,601,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.1 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 39,369,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1381,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,369,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1381,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1381,1999
TOXICOLOGY REVIEW
ARPTDI 45,147,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 0.1 ppm (0.4 mg/m3) DTLVS* 3,75,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 ppm (0.4 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 ppm (0.4 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA ceiling concentration 0.1 ppm (0.39 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM short term exposure limit 0.1 ppm (0.4 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 0.1 ppm (0.4 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.4 mg/m3), short term exposure limit 0.3 ppm (1.2 mg/m3), JAN1993
Occupational Exposure Limit - KOREA ceiling concentration 0.1 ppm (0.4 mg/m3), 2006
Occupational Exposure Limit - MEXICO peak 0.1 ppm (0.4 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.4 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 0.1 ppm (0.39 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.4 mg/m3), Carcinogen, DEC2006
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.1 ppm (0.39 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICHLOROACETYLENE-air Carcinogen ceiling concentration 0.1 ppm NIOSH* DHHS #95-121,1995
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5342;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 3;
Total Number of Employees Exposed 61;
Total Number of Female Employees Exposed 6


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

NOISH PROFILE (DICHLOROACETYLENE), SRC, 4/81

RTECS Compound Description:
   Tumorigen
   Mutagen

Click Here for Additional Information about RTECS

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