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Acetic acid, isobutyl ester

RTECS #: AI4025000

CAS #: 110-19-0


UPDATE: May 2009 MW: 116.18 MF: C6H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Methyl - 1 - propyl acetate
  2. 2 - Methylpropyl acetate
  3. Acetate d'isobutyle (French)
  4. Acetic acid, 2 - methylpropyl ester
  1. Isobutyl acetate
  2. Isobutyl acetate (ACGIH:OSHA)
  3. Isobutylester kyseliny octove (Czech)
  4. beta - Methylpropyl ethanoate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour moderate FCTXAV 16,795,1978
skin
rabbit
500 mg open irritation test mild UCDS** 11/3/1971
skin
rabbit
500 mg/24 hour moderate FCTXAV 16,795,1978


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 8,000 ppm/4 hour N/R AIHAAP 23,95,1962
oral
rat
lethal dose (50 percent kill): 13,400 mg/kg N/R NPIRI* 1,8,1974
oral
rabbit
lethal dose (50 percent kill): 4,763 mg/kg N/R IMSUAI 41,31,1972
skin
rabbit
lethal dose (50 percent kill): >17,400 mg/kg N/R NPIRI* 1,8,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 150 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
HUTOX* -,649,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 150 ppm (700 mg/m3) DTLVS* 3,139,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 150 ppm (700 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 150 ppm (700 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 150 ppm (700 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 150 ppm (700 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 150 ppm (713 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 150 ppm (723 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 150 ppm (710 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 150 ppm (710 mg/m3), VLE 200 ppm (940 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 480 mg/m3 (100 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 150 ppm (700 mg/m3), short term exposure limit 187 ppm (875 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 150 ppm (700 mg/m3);
short term exposure limit 187 ppm (875 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 700 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 150 ppm (713 mg/m3), JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 150 ppm (700 mg/m3), JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 100 ppm (500 mg/m3);
short term exposure limit 150 ppm (700 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (480 mg/m3);
KZG- week 200 ppm (960 mg/m3),DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 150 ppm (724 mg/m3);
short term exposure limit 187 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 150 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 150 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ISOBUTYL ACETATE-air 10 hour time-weighted average 150 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 40410;
Number of Industries 150;
Total Number of Facilities 16,707;
Number of Occupations 81;
Total Number of Employees Exposed 85,472
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 40410;
Number of Industries 113;
Total Number of Facilities 11,899;
Number of Occupations 78;
Total Number of Employees Exposed 160,286;
Total Number of Female Employees Exposed 41,243


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
HUTOX*
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

NIOSH PROFILE (ACETATES), SRI, 2/77

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Primary Irritant

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