CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Urea, 1 - (1 - naphthyl) - 2 - thio -

RTECS #: YT9275000

CAS #: 86-88-4


UPDATE: May 2009 MW: 202.29 MF: C11H10N2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - (1 - Naphthyl) - 2 - thiourea
  2. 1 - Naftil - tiourea (Italian)
  3. 1 - Naftylthioureum (Dutch)
  4. 1 - Naphthalenylthiourea
  5. 1 - Naphthyl thiourea
  6. 1 - Naphthyl - thioharnstoff (German)
  7. 1 - Naphthyl - thiouree (French)
  8. ANTU
  9. ANTU (ACGIH:OSHA)
  10. Alphanaphthyl thiourea
  11. Alphanaphtyl thiouree (French)
  12. Alrato
  13. Anturat
  14. Bantu
  15. Chemical 109
  16. Dirax
  17. Kill kantz
  1. Krysid
  2. Krysid PI
  3. N - (1 - Naphthyl) - 2 - thiourea
  4. Naphtox
  5. RCRA waste number P072
  6. Rat - TU
  7. Rattrack
  8. Smeesana
  9. Thiourea, 1 - naphthalenyl -
  10. U - 5227
  11. USAF EK - P - 5976
  12. alpha - Naftylthiomocovina (Czech)
  13. alpha - Naphthalthioharnstoff (German)
  14. alpha - Naphthothiourea
  15. alpha - Naphthylthiocarbamide
  16. alpha - Naphthylthiourea
  17. alpha - Naphthylthiourea (DOT:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 500 nmol/L (-enzymatic activation step) ENMUDM 3,11,1981
morphological transform hamster embryo 1,600 g/L NCIMAV 58,243,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
mouse
lowest published toxic dose: 5 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors
NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
chicken
lethal dose (50 percent kill): 2,500 mg/kg N/R PSEBAA 62,22,1946
intraperitoneal
dog
lethal dose (50 percent kill): 16 mg/kg N/R ENTOX* -,188,2005
intraperitoneal
guinea pig
lethal dose (50 percent kill): 350 mg/kg N/R PSEBAA 62,22,1946
intraperitoneal
monkey
lethal dose (50 percent kill): 175 mg/kg N/R PSEBAA 62,22,1946
intraperitoneal
mouse
lethal dose (50 percent kill): 10 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat
lethal dose (50 percent kill): 2,470 g/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Pleural effusion
JPETAB 97,432,1949
oral
cat
lethal dose (50 percent kill): 500 mg/kg N/R PSEBAA 62,22,1946
oral
chicken
lethal dose (50 percent kill): 4,250 mg/kg N/R PSEBAA 62,22,1946
oral
dog
lethal dose (50 percent kill): 380 g/kg N/R ENTOX* -,188,2005
oral
monkey
lethal dose (50 percent kill): 4,250 mg/kg N/R 85DPAN -,-,1971/1976
oral
mouse
lethal dose (50 percent kill): 5 mg/kg N/R YKYUA6 28,329,1977
oral
pig
lowest published lethal dose: 50 mg/kg N/R YKYUA6 28,329,1977
oral
rat
lethal dose (50 percent kill): 6 mg/kg N/R AFDOAQ 16,47,1952
unreported route
chicken
lethal dose (50 percent kill): 700 mg/kg N/R 30ZDA9 -,238,1971
unreported route
man
lowest published lethal dose: 588 mg/kg N/R 85DCAI 2,73,1970
unreported route
monkey
lethal dose (50 percent kill): >2 gm/kg N/R BCFAAI 97,289,1958
unreported route
rabbit
lethal dose (50 percent kill): >200 mg/kg N/R BCFAAI 97,289,1958


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.3 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 30,347,1983
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 30,347,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,263,1987
TOXICOLOGY REVIEW
ADCSAJ 13,271,1970
TOXICOLOGY REVIEW
ENTOX* -,188,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.3 mg/m3 DTLVS* 3,14,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.3 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.3 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.3 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.3 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.3 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.3 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.3 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.3 mg/m3, short term exposure limit 0.9 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.3 mg/m3, continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.3 mg/m3 (inhalable), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.3 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.3 mg/m3;
short term exposure limit 0.9 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.3 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.3 mg/m3, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.3 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.3 mg/m3;
KZG- week 0.6 mg/m3, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.3 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ANTU-air 10 hour time-weighted average 0.3 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0294;
Number of Industries 1;
Total Number of Facilities 25;
Number of Occupations 4;
Total Number of Employees Exposed 1,450


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as rodenticide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1- 1950-
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74.
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as rodenticide

NIOSH PROFILE (THIOUREA AND COMPOUNDS), SRC, 1/82

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us