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Uranium

RTECS #: YR3490000

CAS #: 7440-61-1


UPDATE: May 2009 MW: 238.00 MF: U


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Uranium (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
unreported route
rat
lethal dose (50 percent kill): 750 mg/kg N/R GISAAA 37(10),27,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 121.635 mg/kg/6 week- continuous Behavioral: Sleep

Behavioral: Change in psychophysiological tests
NETOX* 26,1015,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3;short term exposure limit 0.6 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
HXPHAU 36,165,1973
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965
TOXICOLOGY REVIEW
DIMON* 46,551,2000
TOXICOLOGY REVIEW
ENTOX* -,406,2005
TOXICOLOGY REVIEW
ENTOX* -,406,2005
TOXICOLOGY REVIEW
JTEHD6 7,297,2004
TOXICOLOGY REVIEW
JTEHD6 7,297,2004
TOXICOLOGY REVIEW
MUREAV 544,273,2003
TOXICOLOGY REVIEW
HBTME* ,881,2007
TOXICOLOGY REVIEW
HTOPA* 1,701,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg/m3 DTLVS* 3,274,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.05 mg(U)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.25 mg(U)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg(U)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.25 mg(U)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, MAR2002
Occupational Exposure Limit - FINLAND time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg/m3, short term exposure limit 0.6 mg/m3, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.2 mg/m3, carcinogen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.2 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.25 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.015 mg/m3, MAC(short term exposure limit) 0.12 mg/m3, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.075 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.075 mg(U)/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.2 mg/m3, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.05 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO URANIUM, insol-air Carcinogen;
10 hour time-weighted average 0.2 mg/m3;
short term exposure limit 0.6 mg/m3
NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO URANIUM, soluble compounds-air Carcinogen;
10 hour time-weighted average 0.05 mg/m3
NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/99/163362)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in nuclear fission power plants
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTME*
HTOPA*
HXPHAU Handbuch der Experimentellen Pharmakologie. (Berlin, Ger.) New series: V.1-49, 1935-78. For publisher information, see HEPHD2.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NETOX* NeuroToxicology (Amsterdam : Elsevier Science) V.1- 1979-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used in nuclear fission power plants

NIOSH PROFILE (URANIUM AND ITS COMPOUNDS), SRC, 4/78

ALT CAS #: 24678-82-8
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