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Silica, amorphous fumed

RTECS #: VV7310000

CAS #: 112945-52-5


UPDATE: May 2009 MW: 60.09 MF: O2Si


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Acticel
  2. Aerosil
  3. Amorphous silica dust
  4. Aquafil
  5. Cab - O - grip II
  6. Cab - O - sil
  7. Cab - O - sperse
  8. Cataloid
  9. Colloidal silica
  10. Colloidal silicon dioxide
  11. Davison SG - 67
  12. Dicalite
  13. Dri - Die insecticide 67
  14. ENT 25,550
  15. Fossil flour
  1. Fumed silica
  2. Fumed silicon dioxide
  3. Ludox
  4. Nalcoag
  5. Nyacol
  6. Nyacol 830
  7. Nyacol 1430
  8. Pyrogenic colloidal silica
  9. SG - 67
  10. Santocel
  11. Silica, amorphous
  12. Silicic anhydride
  13. Silikill
  14. Synthetic amorphous silica, fumed
  15. Vulkasil


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published lethal dose: 50 mg/kg N/R AHBAAM 136,1,1952
intratracheal
mouse
lowest published lethal dose: 96.77 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
TOPADD 33,745,2005
intratracheal
mouse
lowest published toxic dose: 96.77 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOPADD 33,745,2005
intratracheal
mouse
lowest published toxic dose: 50 mg/kg Lung, Thorax, or Respiration: Changes in lung weight TOLED5 175,24,2007
intratracheal
mouse
lowest published toxic dose: 2 mg/kg Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOLED5 175,24,2007
intratracheal
rat
lowest published lethal dose: 10 mg/kg N/R AHBAAM 136,1,1952
intravenous
rat
lethal dose (50 percent kill): 15 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema BSIBAC 44,1685,1968
oral
rat
lethal dose (50 percent kill): 3,160 mg/kg N/R ARSIM* 20,9,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 154 mg/m3/6 hour/4 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Other proteins
FAATDF 16,590,1991
inhalation
rat
lowest published toxic concentration: 5.41 mg/m3/5 day- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
FCTOD7 45,1856,2007
inhalation
rat
lowest published toxic concentration: 1.39 mg/m3/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 45,1856,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 42,39,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 68,41,1997
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 68,41,1997
TOXICOLOGY REVIEW
NTIS** CONF-691001
TOXICOLOGY REVIEW
ECRVE8 6,197,1988


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - dust in air time-weighted average 20 million particles per cubic foot DTLWS* 3,33,1973
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 mg/m3 (respirable dust), JUL2008


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Silica, amorphous, 7501
OSHA ANALYTICAL METHOD #ID-125G


REFERENCES:

CODEN
REFERENCE

AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705)
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
ECRVE8 Environmental Carcinogenesis Reviews. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1985-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-

Used as a mineral, natural or synthetic fiber

NIOSH PROFILE (SEWAGE TREATMENT), FIRL, 4/78

ALT CAS #: 50926-93-7
ALT CAS #: 67256-35-3
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