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Selenium

RTECS #: VS7700000

CAS #: 7782-49-2


UPDATE: May 2009 MW: 78.96 MF: Se


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. C.I. 77805
  2. Colloidal selenium
  3. Elemental selenium
  4. Selen (Polish)
  5. Selenate
  6. Selenium base
  1. Selenium dust
  2. Selenium elemental
  3. Selenium homopolymer
  4. Selenium (ACGIH)
  5. Selenium alloy
  6. Vandex


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 134 mg/kg (multigenerations) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
AEHLAU 23,102,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 480 mg/kg/60 day- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
YMBUA7 11,368,1960


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 33 mg/m3/8 hour Blood: Hemorrhage

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Changes in lung weight
AMIHBC 4,458,1951
inhalation
rat
lowest published lethal concentration: 30 mg/m3 Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
HBTME* -,783,2007
intravenous
rat
lethal dose (50 percent kill): 6 mg/kg N/R AMIHBC 4,458,1951
intravenous
rabbit
lowest published lethal dose: 2,500 g/kg N/R JOBSAK 35,693,1928
oral
rat
lethal dose (50 percent kill): 6,700 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Other changes
TXAPA9 20,89,1971
parenteral
cattle
lowest published lethal dose: 0.5 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
VCVN5* -,268,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
human
lowest published toxic dose: 23.7 mg/kg/13 week- continuous Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Skin and Appendages: Other: Nails
VCVN5* -,273,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg/m3 DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 9,245,1975
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 9,245,1975
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
CTOXAO 6,459,1973
TOXICOLOGY REVIEW
CTOXAO 5,175,1972
TOXICOLOGY REVIEW
CRTXB2 4(3),271,1976
TOXICOLOGY REVIEW
JAVMA4 164,277,1974
TOXICOLOGY REVIEW
CTOXAO 5,151,1972
TOXICOLOGY REVIEW
IJMDAI 10,416,1974
TOXICOLOGY REVIEW
JAMAAP 116,562,1941
TOXICOLOGY REVIEW
CHREAY 28,179,1941
TOXICOLOGY REVIEW
ADTEAS 5,51,1972
TOXICOLOGY REVIEW
PHREA7 23,305,1943
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
85CVA2 5,63,1970
TOXICOLOGY REVIEW
PEXTAR 12,102,1969
TOXICOLOGY REVIEW
BNYMAM 54,413,1978
TOXICOLOGY REVIEW
AMTODM 3,209,1977
TOXICOLOGY REVIEW
JEPTDQ 4(1),193,1980
TOXICOLOGY REVIEW
MEHYDY 5,877,1979
TOXICOLOGY REVIEW
CTOXAO 17,171,1980
TOXICOLOGY REVIEW
JACTDZ 5(1),45,1986
TOXICOLOGY REVIEW
TOLED5 137,103,2003
TOXICOLOGY REVIEW
PHTOEH 93,105,2003
TOXICOLOGY REVIEW
NRTXDN 27,429,2006
TOXICOLOGY REVIEW
TOXID9 227,1,2006
TOXICOLOGY REVIEW
JJATDK 26,191,2006
TOXICOLOGY REVIEW
ENTOX* -,774,2005
TOXICOLOGY REVIEW
REPTED 23,260,2007
TOXICOLOGY REVIEW
HBTME* ,783,2007
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.2 mg(Se)/m3 DTLVS* 3,224,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.2 mg(Se)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg(Se)/m3, OCT 2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.05 mg/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg/m3, short term exposure limit 0.4 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 mg/m3, APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.2 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg(Se)/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg/m3, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 2 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 mg/m3 (total dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg/m3,KZG- week 0.2 mg/m3, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO SELENIUM COMPOUNDS (as Se)-air 10 hour time-weighted average 0.2 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 68295;
Number of Industries 8;
Total Number of Facilities 403;
Number of Occupations 10;
Total Number of Employees Exposed 2,147
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2074;
Number of Industries 2;
Total Number of Facilities 105;
Number of Occupations 2;
Total Number of Employees Exposed 105
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 68295;
Number of Industries 23;
Total Number of Facilities 1,102;
Number of Occupations 68;
Total Number of Employees Exposed 27,208;
Total Number of Female Employees Exposed 9,632


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/97/121032/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in pigments, photoelectric cells, metallurgy and electronics
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Elements by ICP, 7300
OSHA ANALYTICAL METHOD #ID-125G


REFERENCES:

CODEN
REFERENCE

85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued.
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMTODM Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10016) V.1, 1976-79. Discontinued.
BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
HBTME*
HTOPA*
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JOBSAK Journal of Obstetrics and Gynaecology of the British Empire. (London, UK) V.1-27, 1902-15; V.28-67, 1921-60. For publisher information, see BJOGAS.
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
MEHYDY Medical Hypotheses. (Churchill Livingstone Inc., 1560 Broadway, New York, NY 10036) V.1- 1975-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960-
PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville Pike, Bethesda, MD 20814) V.1- 1921-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
YMBUA7 Yokohama Medical Bulletin. (Yokohama City Univ. School of Medicine, 2-33, Yokohama 232, Japan) V.1- 1950-

Used in pigments, photoelectric cells, metallurgy and electronics

NIOSH PROFILE (SELENIUM AND ITS COMPOUND), SRC, 4/78

NIOSH PROFILE (TIRE MANUFACTURING), SRI, 2/77

NIOSH PROFILE (TIRE MANUFACTURING), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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