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Propyl alcohol

Related Pages
RTECS #
UH8225000
CAS #
71-23-8
See: NMAM or OSHA Methods
Updated
December 2018
Molecular Weight
60.11
Molecular Formula
C3H8O
Synonyms
1-Hydroxypropane
1-Propanol
1-Propyl alcohol
Alcool propilico (Italian)
Alcool propylique (French)
Ethyl carbinol
n-Propanol
n-Propyl alcohol
n-Propyl alcohol (ACGIH:OSHA)
n-Propyl alkohol (German)
Optal
Osmosol Extra
Propan-1-ol
Propanol
Propanol-1
Propanole (German)
Propanolen (Dutch)
Propanoli (Italian)
Propylic alcohol
Propylowy alkohol (Polish)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg/24H moderate85JCAE -,191,1986
skin /human 100%/47H mildCODEDG 39,240,1998
skin /human 100%/24H mildCODEDG 68,192,1988
skin /rabbit 500 mg open irritation test mildUCDS** 6/28/1972

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Escherichia coli4 pph (-enzymatic activation step)ABMGAJ 23,843,1969
sex chromosome loss and nondisjunction/Aspergillus nidulans18000 ppmMUREAV 215,187,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 7000 ppm/7H (6W male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)NTOTDY 7,779,1985
inhalation/rat 7000 ppm/7H (1-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)FCTOD7 26,247,1988
inhalation/rat 10000 ppm/7H (1-19D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system		FCTOD7 26,247,1988

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 50 gm/kg/81W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia		ARGEAR 45,19,1975
subcutaneous/rat lowest published toxic dose: 6 gm/kg/95W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Blood: Leukemia		ARGEAR 45,19,1975

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 220 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Rat, myocard Inhibitor Concentration Low: 150 mmol/L/6HIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.TIVIEQ 26,849,2012
In Vitro/Rat, neurons Inhibitor Concentration Low: 2.5 mmol/L/24HIn Vitro Toxicity Studies: Cell membrane integrity (prelabeled cells): release of radioactive isotopes ([51Cr], [3H]-thymidine, [3H]-proline, [35S]- or [75Se]-methionine, 5-[125I]-2-deoxy-uridine) or fluorescent dyes (bis-carboxyethyl-carboxyfluorescein (BCECF) or calcein-AM)TOXRE* 2,729,2015
inhalation/mouse lethal concentration (50 percent kill): 48000 mg/m3Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes		VCVGK* -,96,1984
inhalation/mouse lethal concentration (50 percent kill): 48 gm/m3GTPZAB 18(3),48,1974
inhalation/rat Lowest published lethal concentration: 4000 ppm/4HAMIHBC 10,61,1954
inhalation/rat Lowest published lethal concentration: 9800 mg/m3/4HBehavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes		VCVGK* -,96,1984
intraperitoneal/guinea pig lethal dose (50 percent kill): 1208 mg/kgEVHPAZ 61,321,1985
intraperitoneal/hamster lethal dose (50 percent kill): 2338 mg/kgEVHPAZ 61,321,1985
intraperitoneal/mouse lethal dose (50 percent kill): 3125 mg/kgEVHPAZ 61,321,1985
intraperitoneal/rabbit lethal dose (50 percent kill): 515 mg/kgEVHPAZ 61,321,1985
intraperitoneal/rat lethal dose (50 percent kill): 2164 mg/kgEVHPAZ 61,321,1985
intravenous/cat lowest published lethal dose: 4008 mg/kgJPETAB 16,1,1920
intravenous/mouse lethal dose (50 percent kill): 697 mg/kgEVHPAZ 61,321,1985
intravenous/rabbit lethal dose (50 percent kill): 483 mg/kgEVHPAZ 61,321,1985
intravenous/rat lethal dose (50 percent kill): 590 mg/kgEVHPAZ 61,321,1985
oral/Dog lowest published lethal dose: 3 gm/kgGastrointestinal: Other changes

Blood: Hemorrhage		COREAF 81,192,1875
oral/mouse lethal dose (50 percent kill): 6800 mg/kgPSDTAP 9,276,1968
oral/mouse lowest published lethal dose: 140 mg/kgBehavioral: General anestheticVCVGK* -,96,1984
oral/rabbit lowest published lethal dose: 3500 mg/kgBehavioral: General anestheticVCVGK* -,96,1984
oral/rabbit lethal dose (50 percent kill): 2825 mg/kgIMSUAI 41,31,1972
oral/rat lethal dose (50 percent kill): 1870 mg/kgAMIHBC 10,61,1954
oral/rat lethal dose (50 percent kill): 2200 mg/kgBehavioral: General anestheticVCVGK* -,96,1984
oral/woman lowest published lethal dose: 5700 mg/kgCardiac: Other changes

Lung, Thorax, or Respiration: Other changes		ATXKA8 16,84,1956
skin/rabbit lethal dose (50 percent kill): 5040 mg/kgAMIHBC 10,61,1954
subcutaneous/Dog lowest published lethal dose: 4 gm/kgGastrointestinal: Other changes

Blood: Hemorrhage		COREAF 81,192,1875
subcutaneous/mammal (species unspecified) lowest published lethal dose: 5 gm/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: General anesthetic

Lung, Thorax, or Respiration: Other changes		ATXKA8 16,84,1956
subcutaneous/mouse lethal dose (50 percent kill): 4700 mg/kgTXAPA9 18,185,1971
subcutaneous/rabbit lowest published lethal dose: 3 gm/kgBDBU** -,-,1930
unreported route/rabbit lowest published lethal dose: 4500 mg/kgTHMOAM 6,327,1892

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 20 mg/m3/24H/90D- continuousBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Liver: Multiple effects		VCVGK* -,98,1994
oral/rat lowest published toxic dose: 7 mL/kg/7D- intermittentLiver: Other changes

Biochemical: Effect on specific coenzyme: B vitamins including folate		JDGRAX 10(1-2),25,1978

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 100 ppmDTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOLED5 140-141,53,2003
TOXICOLOGY REVIEWREPTED 32,142,2011
TOXICOLOGY REVIEWREPTED 58,252,2015
TOXICOLOGY REVIEWRTOPDW 59,364,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,290,1998
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 200 ppm (490 mg/m3)DTLVS* 3,217,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 200 ppm (492 mg/m3), short term exposure limit 250 ppm (614 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 200 ppm (500 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 200 ppm (499 mg/m3), MAR2002
Occupational Exposure Limit-BELGIUMshort term exposure limit 250 ppm (623 mg/m3), Skin, MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 200 ppm (500 mg/m3), skin, MAY2011
Occupational Exposure Limit-FRANCEVME 200 ppm (500 mg/m3), FEB2006
Occupational Exposure Limit-ICELANDtime-weighted average 200 ppm (500 mg/m3), skin, NOV2011
Occupational Exposure Limit-KOREAtime-weighted average 200 ppm (500 mg/m3), short term exposure limit 250 ppm (625 mg/m3), skin, 2006
Occupational Exposure Limit-MEXICOtime-weighted average 200 ppm (500 mg/m3);short term exposure limit 250 ppm (skin), 2004
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 200 ppm (492 mg/m3), short term exposure limit 250 ppm (614 mg/m3), skin, JAN2002
Occupational Exposure Limit-NORWAYtime-weighted average 100 ppm (245 mg/m3), JAN1999
Occupational Exposure Limit-PERUtime-weighted average 200 ppm (491 mg/m3); short term exposure limit 250 ppm (614 mg/m3), JUL2005
Occupational Exposure Limit-POLANDMAC(time-weighted average) 200 mg/m3, MAC(short term exposure limit) 600 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAtime-weighted average 10 mg/m3, short term exposure limit 30 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 150 ppm (350 mg/m3);short term exposure limit 250 ppm (600 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 200 ppm (500 mg/m3), skin, JAN2011
Occupational Exposure Limit-TURKEYtime-weighted average 200 ppm (500 mg/m3), JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 200 ppm (500 mg/m3);short term exposure limit 250 ppm (625 mg/m3), skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 200 ppm (500 mg/m3)CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 200 ppm (500 mg/m3)CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 200 ppm (500 mg/m3)CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 200 ppm (500 mg/m3)CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPYL ALCOHOL-airtime-weighted average 200 ppm (Sk);short term exposure limit 250 ppm (Sk)NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code M0256; Number of Industries 130; Total Number of Facilities 17036; Number of Occupations 99; Total Number of Employees Exposed 226129; Total Number of Female Employees Exposed 84196
National Occupational Hazard Survey 1974Hazard Code M0256; Number of Industries 151; Total Number of Facilities 18176; Number of Occupations 103; Total Number of Employees Exposed 122603

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols II, 1401
Page last reviewed: November 16, 2018
Content source: National Institute for Occupational Safety and Health