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Propionitrile

RTECS #: UF9625000

CAS #: 107-12-0


UPDATE: April 2002 MW: 55.09 MF: C3H5N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Cyanoethane
  2. Ether cyanatus
  3. Ethyl cyanide
  4. Ethylkyanid (Czech)
  5. Hydrocyanic ether
  1. Propanenitrile
  2. Propannitril (Czech)
  3. Propionic nitrile
  4. Propiononitrile
  5. RCRA waste number P101


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg/24 hour moderate 85JCAE -,898,1986
skin
rabbit
500 mg/24 hour mild 85JCAE -,898,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster
51 ppm MUREAV 259,165,1991
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 15,100 mg/L MUREAV 224,31,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 200 ppm/6 hour (6-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 20,365,1993
inhalation
rat
lowest published toxic concentration: 100 ppm/6 hour (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system FAATDF 20,365,1993
intraperitoneal
hamster
lowest published toxic dose: 238 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Central nervous system
TJADAB 23,317,1981
intraperitoneal
hamster
lowest published toxic dose: 238 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TJADAB 23,325,1981
intraperitoneal
hamster
lowest published toxic dose: 238 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 23,325,1981
oral
rat
lowest published toxic dose: 1,120 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FAATDF 7,33,1986
oral
rat
lowest published toxic dose: 180 mg/kg (10 day pregnant) Reproductive: Other effects to embryo or fetus TXAPA9 163,149,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 163 ppm/1 hour Liver: Other changes CTOXAO 18,991,1981
inhalation
rat
lowest published lethal concentration: 500 ppm/4 hour N/R AMIHBC 4,119,1951
intraperitoneal
guinea pig
lethal dose (50 percent kill): 10 mg/kg N/R 38MKAJ 2C,4872,1982
intraperitoneal
mouse
lethal dose (50 percent kill): 28 mg/kg Eye: Corneal damage

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 59,589,1981
intraperitoneal
rat
lethal dose (50 percent kill): 25 mg/kg N/R 38MKAJ 2C,4872,1982
intravenous
rabbit
lowest published lethal dose: 50 mg/kg N/R CRSBAW 1,251,1889
oral
guinea pig
lethal dose (50 percent kill): 25 mg/kg N/R 38MKAJ 2C,4872,1982
oral
mouse
lethal dose (50 percent kill): 35,797 g/kg N/R NEZAAQ 39,423,1984
oral
rat
lethal dose (50 percent kill): 39 mg/kg N/R AMIHBC 4,119,1951
subcutaneous
frog
lowest published lethal dose: 8 gm/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
AIPTAK 5,161,1899
subcutaneous
guinea pig
lethal dose (50 percent kill): 18,100 g/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Gastrointestinal: Nausea or vomiting
MELAAD 47,192,1956
subcutaneous
rabbit
lowest published lethal dose: 60 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation
AIPTAK 5,161,1899
skin
guinea pig
lowest published lethal dose: 5 gm/kg N/R 38MKAJ 2C,4872,1982
skin
rabbit
lethal dose (50 percent kill): 210 L/kg N/R AMIHBC 4,119,1951
unreported route
dog
lowest published lethal dose: 50 mg/kg N/R CRSBAW 1,251,1889


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 209 ppm/6 hour/14 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 5,113,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PROPIONITRILE-air 10 hour time-weighted average 6 ppm NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent in petroleum refining, raw material for drug manufacture, setting agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8903
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a solvent in petroleum refining, raw material for drug manufacture, setting agent

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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