Propene, 3-chloro-
RTECS #
UC7350000
CAS #
Updated
September 2018
Molecular Weight
76.53
Molecular Formula
C3H5Cl
Synonyms
1-Chloro propene-2
1-Chloro-2-propene
1-Propene, 3-chloro-
2-Propenyl chloride
3-Chloro-1-propylene
3-Chloroprene
3-Chloropropene
3-Chloropropene-1
3-Chloropropylene
3-Chlorpropen (German)
Allile (cloruro di) (Italian)
Allyl chloride
Allyl chloride (ACGIH:OSHA)
Allylchlorid (German)
Allyle (chlorure d') (French)
alpha-Chloropropylene
Chlorallylene
Chloroallylene
NCI-C04615
p-Aminopropiofenon (Czech)
1-Chloro-2-propene
1-Propene, 3-chloro-
2-Propenyl chloride
3-Chloro-1-propylene
3-Chloroprene
3-Chloropropene
3-Chloropropene-1
3-Chloropropylene
3-Chlorpropen (German)
Allile (cloruro di) (Italian)
Allyl chloride
Allyl chloride (ACGIH:OSHA)
Allylchlorid (German)
Allyle (chlorure d') (French)
alpha-Chloropropylene
Chlorallylene
Chloroallylene
NCI-C04615
p-Aminopropiofenon (Czech)
Skin and Eye Irritation and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| eye /guinea pig | 290 ppm/6H | JIHTAB 22,79,1940 | |
| eye /rabbit | 500 mg | moderate | AJOPAA 29,1363,1946 |
| eye /rat | 290 ppm/6H | JIHTAB 22,79,1940 | |
| skin /rabbit | 10 mg/24H open irritation test | JIHTAB 30,63,1948 |
Mutation Data and Reference
| System Test | Route/Organism/Tissue | Dose | Reference |
|---|---|---|---|
| DNA repair | /Escherichia coli | 9380 µg/plate | MUREAV 57,11,1978 |
| gene conversion and mitotic recombination | /Saccharomyes cerevisiae | 184 µmol/L | MUREAV 57,11,1978 |
| mutation in microorganisms | /Salmonella typhimurium | 250 µg/plate/72H (-enzymatic activation step) | TOXID9 228,66,2006 |
| mutation in microorganisms | /Salmonella typhimurium | 250 µg/plate/72H (+enzymatic activation step) | TOXID9 228,66,2006 |
| mutation in microorganisms | /Other microorganisms | 9380 µg/plate (-enzymatic activation step) | CBINA8 30,9,1980 |
| mutation in microorganisms | /Salmonella typhimurium | 938 µg/plate (+enzymatic activation step) | MUREAV 57,11,1978 |
| mutation in microorganisms | /Escherichia coli | 20 µL/plate (-enzymatic activation step) | MUREAV 153,57,1985 |
| Unscheduled DNA Synthesis | HeLa cell/human | 1 mmol/L | CALEDQ 20,263,1983 |
Reproductive Effects Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/rat | 300 ppm/7H (6-15D pregnant) | Reproductive: Specific developmental abnormalities: Musculoskeletal system | FAATDF 3,437,1983 |
| intraperitoneal/rat | 1200 mg/kg (1-15D pregnant) | Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other developmental abnormalities | SWEHDO 7(Suppl 4),66,1981 |
| oral/mouse | 4 gm/kg (7-14D pregnant) | Reproductive: Effects on embryo or fetus: Fetal death | NTIS** PB86-197605 |
Tumorigenic Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| intraperitoneal/mouse | lowest published toxic dose: 5880 mg/kg/8W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Lung, Thorax, or Respiration: Tumors | CNREA8 39,391,1979 |
| oral/mouse | toxic dose: 78 gm/kg/78W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | NCITR* NCI-TR-73,1978 |
| oral/mouse | lowest published toxic dose: 50 gm/kg/78W- intermittent | Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Gastrointestinal: Tumors | NCITR* NCI-TR-73,1978 |
Acute Toxicity Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/cat | Lowest published lethal concentration: 10500 mg/m3/2H | Behavioral: Somnolence (general depressed activity) Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression | EESADV 6,19,1982 |
| inhalation/guinea pig | lowest published toxic concentration: 1000 mg/m3/2H | Behavioral: General anesthetic | VCVGH* -,467,1990 |
| inhalation/guinea pig | lethal concentration (50 percent kill): 5800 mg/m3/2H | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression | EESADV 6,19,1982 |
| inhalation/guinea pig | Lowest published lethal concentration: 10000 mg/m3/4H | VCVGH* -,467,1990 | |
| inhalation/human | Lowest published lethal concentration: 3000 ppm | 34ZIAG -,86,1969 | |
| inhalation/mouse | lethal concentration (50 percent kill): 11500 mg/m3/2H | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression | EESADV 6,19,1982 |
| inhalation/mouse | lethal concentration (16 percent kill): 5000 mg/m3 | VCVGH* -,467,1990 | |
| inhalation/mouse | lethal concentration (50 percent kill): 6600 mg/m3 | VCVGH* -,467,1990 | |
| inhalation/mouse | Lowest published lethal concentration: 8100 mg/m3 | VCVGH* -,467,1990 | |
| inhalation/mouse | lethal concentration (84 percent kill): 8600 mg/m3 | VCVGH* -,467,1990 | |
| inhalation/rabbit | Lowest published lethal concentration: 22500 mg/m3/2H | Eye: Lacrimation Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression | EESADV 6,19,1982 |
| inhalation/rat | lethal concentration (50 percent kill): 11 gm/m3/2H | Eye: Lacrimation Gastrointestinal: Ulceration or bleeding from duodeum Lung, Thorax, or Respiration: Respiratory depression | EESADV 6,19,1982 |
| inhalation/rat | lethal concentration (16 percent kill): 6400 mg/m3 | VCVGH* -,467,1990 | |
| inhalation/rat | lethal concentration (50 percent kill): 8200 mg/m3 | VCVGH* -,467,1990 | |
| inhalation/rat | lethal concentration (84 percent kill): 10000 mg/m3 | VCVGH* -,467,1990 | |
| inhalation/rat | lowest published toxic concentration: 1000 mg/m3/2H | Behavioral: General anesthetic | VCVGH* -,467,1990 |
| inhalation/rat | Lowest published lethal concentration: 20000 mg/m3/2H | VCVGH* -,467,1990 | |
| inhalation/rat | Lowest published lethal concentration: 10000 mg/m3/4H | VCVGH* -,467,1990 | |
| intraperitoneal/mouse | lethal dose (50 percent kill): 155 mg/kg | SCCUR* -,1,1961 | |
| oral/mouse | lethal dose (50 percent kill): 425 mg/kg | Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea | EESADV 6,19,1982 |
| oral/mouse | lethal dose (50 percent kill): 500 mg/kg | VCVGH* -,468,1990 | |
| oral/rabbit | lethal dose (50 percent kill): 300 mg/kg | VCVGH* -,468,1990 | |
| oral/rat | lethal dose (50 percent kill): 450 mg/kg | VCVGH* -,468,1990 | |
| oral/rat | lethal dose (50 percent kill): 460 mg/kg | Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Dyspnea | EESADV 6,19,1982 |
| skin/rabbit | lethal dose (50 percent kill): 2066 mg/kg | JIHTAB 30,63,1948 |
Other Multiple Dose Data and References
| Route/Organism | Dose | Effect | Reference |
|---|---|---|---|
| inhalation/guinea pig | lowest published toxic concentration: 8 ppm/7H/35D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | AIHAAP 20,217,1959 |
| inhalation/rabbit | lowest published toxic concentration: 206 mg/m3/6H/13W- intermittent | Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Peripheral Nerve and Sensation: Structural change in nerve or sheath Behavioral: Muscle weakness | EESADV 6,19,1982 |
| inhalation/rabbit | lowest published toxic concentration: 8 ppm/7H/35D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | AIHAAP 20,217,1959 |
| inhalation/rabbit | lowest published toxic concentration: 206 mg/m3/6H/13W- intermittent | Spinal Cord: Demyelination Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral: Muscle weakness | EESADV 6,19,1982 |
| inhalation/rabbit | lowest published toxic concentration: 25 mg/m3/8H/75D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGH* -,469,1990 |
| inhalation/rat | lowest published toxic concentration: 400 mg/m3/4W- continuous | Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Other changes Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGH* -,470,1990 |
| inhalation/rat | lowest published toxic concentration: 1.1 mg/m3/16W- continuous | Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGH* -,469,1990 |
| inhalation/rat | lowest published toxic concentration: 9 mg/m3/180D- continuous | Kidney, Ureter, and Bladder: Changes primarily in glomeruli Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Liver: Other changes | VCVGH* -,469,1990 |
| inhalation/rat | lowest published toxic concentration: 25 mg/m3/8H/75D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGH* -,469,1990 |
| inhalation/rat | lowest published toxic concentration: 8 ppm/7H/35D- intermittent | Liver: Other changes Kidney, Ureter, and Bladder: Other changes Endocrine: Changes in spleen weight | AIHAAP 20,217,1959 |
| inhalation/rat | lowest published toxic concentration: 250 ppm/6H/90D- intermittent | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, and Bladder: Other changes | NTIS** OTS0539130 |
| oral/mouse | lowest published toxic dose: 15300 mg/kg/17W- intermittent | Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Structural change in nerve or sheath | ANPTAL 55,125,1981 |
| oral/rat | lowest published toxic dose: 3600 mg/kg/6W- intermittent | Behavioral: Change in motor activity (specific assay) Behavioral: Muscle weakness Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | TOXID9 227,36,2006 |
| oral/rat | lowest published toxic dose: 1800 mg/kg/3W- intermittent | Biochemical: Metabolism (intermediary): Lipids including transport | TOXID9 227,36,2006 |
| oral/rat | lowest published toxic dose: 3600 mg/kg/6W- intermittent | Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Behavioral: Muscle weakness | TXCYAC 231,58,2007 |
| subcutaneous/rat | lowest published toxic dose: 5100 mg/kg/12W- intermittent | Brain and Coverings: Other degenerative changes Spinal Cord: Other degenerative changes Biochemical: Metabolism (intermediary): Other proteins | TXCYAC 191,33,2003 |
| subcutaneous/rat | lowest published toxic dose: 9949 mg/kg/13W- intermittent | Spinal Cord: Other degenerative changes Peripheral Nerve and Sensation: Sensory change involving peripheral nerve Peripheral Nerve and Sensation: Recording from peripheral motor nerve | ENVRAL 63,229,1993 |
| subcutaneous/rat | lowest published toxic dose: 1350 mg/kg/9D- intermittent | Peripheral Nerve and Sensation: Structural change in nerve or sheath Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Changes in: Ca | ZYYZEW 3,293,1989 |
Reviews
| Organization | Standard | Reference |
|---|---|---|
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-time-weighted average 1 ppm;short term exposure limit 2 ppm | DTLVS* TLV/BEI,2013 |
| American Conference of Governmental Industrial Hygienists (ACGIH) | Threshold Limit Value-Confirmed animal carcinogen | DTLVS* TLV/BEI,2013 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 36,39,1985 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Animal Inadequate Evidence | IMEMDT 71,1231,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human No Adequate Data | IMEMDT 36,39,1985 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Human Inadequate Evidence | IMEMDT 71,1231,1999 |
| International Agency for Research on Cancer (IARC) | Cancer Review:Group 3 | IMEMDT 71,1231,1999 |
| TOXICOLOGY REVIEW | EVHPAZ 21,251,1977 | |
| TOXICOLOGY REVIEW | MUREAV 543,201,2003 | |
| TOXICOLOGY REVIEW | MUREAV 567,347,2004 | |
| TOXICOLOGY REVIEW | FCTOD7 47,1287,2009 | |
| TOXICOLOGY REVIEW | FCTOD7 55,596,2013 | |
| TOXICOLOGY REVIEW | FCTOD7 106,609,2017 |
Standards and Regulations
| Organization | Standard | Reference |
|---|---|---|
| Mine Safety and Health Administration (MSHA) STANDARD-air | time-weighted average 1 ppm (3 mg/m3) | DTLVS* 3,8,1971 |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV; | ||
| Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV | ||
| Occupational Exposure Limit-AUSTRALIA | time-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), JUL2008 | |
| Occupational Exposure Limit-AUSTRIA | MAK-TMW 1 ppm (3 mg/m3);KZW 1 ppm (3 mg/m3), skin, 2007 | |
| Occupational Exposure Limit-BELGIUM | time-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), MAR2002 | |
| Occupational Exposure Limit-DENMARK | time-weighted average 1 ppm (3 mg/m3), carc, MAY2011 | |
| Occupational Exposure Limit-FINLAND | time-weighted average 1 ppm (3.2 mg/m3), short term exposure limit 3 ppm (9.5 mg/m3), NOV2011 | |
| Occupational Exposure Limit-FRANCE | VME 1 ppm (3 mg/m3), C3 Carcinogen, FEB2006 | |
| Occupational Exposure Limit-HUNGARY | time-weighted average 3 mg/m3, short term exposure limit 3 mg/m3, SEP2000 | |
| Occupational Exposure Limit-ICELAND | time-weighted average 1 ppm (3 mg/m3), NOV2011 | |
| Occupational Exposure Limit-INDIA | time-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), JAN1993 | |
| Occupational Exposure Limit-KOREA | time-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), 2006 | |
| Occupational Exposure Limit-MEXICO | time-weighted average 1 ppm (3 mg/m3);short term exposure limit 2 ppm, 2004 | |
| Occupational Exposure Limit-NEW ZEALAND | time-weighted average 1 ppm (3 mg/m3); short term exposure limit 2 ppm (6 mg/m3), JAN2002 | |
| Occupational Exposure Limit-NORWAY | time-weighted average 1 ppm (3 mg/m3), JAN1999 | |
| Occupational Exposure Limit-PERU | time-weighted average 1 ppm (3.1 mg/m3); short term exposure limit 2 ppm (6.2 mg/m3), JUL2005 | |
| Occupational Exposure Limit-RUSSIA | short term exposure limit 0.3 mg/m3, Skin, JUN2003 | |
| Occupational Exposure Limit-SWEDEN | time-weighted average 1 ppm (3 mg/m3);short term exposure limit 3 ppm (9 mg/m3), Skin, JUN2005 | |
| Occupational Exposure Limit-SWITZERLAND | ceiling concentration 1 ppm (3 mg/m3), carc 3, skin, JAN2011 | |
| Occupational Exposure Limit-THE NETHERLANDS | MAC-TGG 3 mg/m3, 2003 | |
| Occupational Exposure Limit-TURKEY | time-weighted average 1 ppm (3 mg/m3), JAN1993 | |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8H time-weighted average 1 ppm (3 mg/m3) | CFRGBR 29,1926.55,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8H time-weighted average 1 ppm (3 mg/m3) | CFRGBR 41,50-204.50,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8H time-weighted average 1 ppm (3 mg/m3) | CFRGBR 29,1910.1000,1994 |
| Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8H time-weighted average 1 ppm (3 mg/m3) | CFRGBR 29,1915.1000,1993 |
NIOSH Documentation and Surveillance
| Organization | Standard | Reference |
|---|---|---|
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ALLYL CHLORIDE-air | 10H time-weighted average 1 ppm;short term exposure limit 3 ppm | NIOSH* DHHS #92-100,1992 |
| National Occupational Exposure Survey 1983 | Hazard Code X3205; Number of Industries 10; Total Number of Facilities 159; Number of Occupations 15; Total Number of Employees Exposed 3193; Total Number of Female Employees Exposed 325 |
Status in Federal Agencies
| Organization | Reference |
|---|---|
| EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; S cerevisiae gene conversion | |
| EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis | |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
| EPA TSCA Section 8(d) unpublished health/safety studies | |
| EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
| NCI Carcinogenesis Bioassay (gavage);equivocal evidence:mouse | NCITR* NCI-TR-73,1978 |
| NCI Carcinogenesis Bioassay (gavage);no evidence:rat | NCITR* NCI-TR-73,1978 |
| NIOSH Analytical Method, 1994: Allyl chloride, 1000 | |
| On EPA IRIS database |
Page last reviewed: November 16, 2018
Content
source: National Institute for Occupational Safety and Health