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Propene, 3 - chloro -

RTECS #: UC7350000

CAS #: 107-05-1


UPDATE: May 2009 MW: 76.53 MF: C3H5Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 1 - Chloro propene - 2
  2. 1 - Chloro - 2 - propene
  3. 1 - Propene, 3 - chloro -
  4. 2 - Propenyl chloride
  5. 3 - Chloro - 1 - propylene
  6. 3 - Chloroprene
  7. 3 - Chloropropene
  8. 3 - Chloropropene - 1
  9. 3 - Chloropropylene
  10. 3 - Chlorpropen (German)
  1. Allile (cloruro di) (Italian)
  2. Allyl chloride
  3. Allyl chloride (ACGIH:OSHA)
  4. Allylchlorid (German)
  5. Allyle (chlorure d') (French)
  6. Chlorallylene
  7. Chloroallylene
  8. NCI - C04615
  9. alpha - Chloropropylene
  10. p - Aminopropiofenon (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
guinea pig
290 ppm/6 hour N/R JIHTAB 22,79,1940
eye
rat
290 ppm/6 hour N/R JIHTAB 22,79,1940
eye
rabbit
500 mg moderate AJOPAA 29,1363,1946
skin
rabbit
10 mg/24 hour open irritation test moderate JIHTAB 30,63,1948


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA repair Escherichia coli 9,380 g/plate MUREAV 57,11,1978
unscheduled DNA synthesis human HeLa cell 1 mmol/L CALEDQ 20,263,1983
mutation in microorganisms Escherichia coli 20 L/plate (-enzymatic activation step) MUREAV 153,57,1985
mutation in microorganisms other microorganisms 9,380 g/plate (-enzymatic activation step) CBINA8 30,9,1980
mutation in microorganisms Salmonella typhimurium 938 g/plate (+enzymatic activation step) MUREAV 57,11,1978
mutation in microorganisms Salmonella typhimurium 250 g/plate/72 hour (-enzymatic activation step) TOXID9 228,66,2006
mutation in microorganisms Salmonella typhimurium 250 g/plate/72 hour (+enzymatic activation step) TOXID9 228,66,2006
gene conversion and mitotic recombination Saccharomyes cerevisiae 184 mol/L MUREAV 57,11,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 300 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FAATDF 3,437,1983
intraperitoneal
rat
lowest published toxic dose: 1,200 mg/kg (1-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
SWEHDO 7(Suppl 4),66,1981
oral
mouse
lowest published toxic dose: 4 gm/kg (7-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death NTIS** PB86-197605


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 5,880 mg/kg/8 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
CNREA8 39,391,1979
oral
mouse
lowest published toxic dose: 50 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NCITR* NCI-TR-73,1978
oral
mouse
toxic dose : 78 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NCITR* NCI-TR-73,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 10,500 mg/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression
EESADV 6,19,1982
inhalation
guinea pig
lethal concentration (50 percent kill): 5,800 mg/m3/2 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
EESADV 6,19,1982
inhalation
guinea pig
lowest published lethal concentration: 10,000 mg/m3/4 hour N/R VCVGH* -,467,1990
inhalation
guinea pig
lowest published toxic concentration: 1,000 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,467,1990
inhalation
human
lowest published lethal concentration: 3,000 ppm N/R 34ZIAG -,86,1969
inhalation
mouse
lethal concentration (50 percent kill): 11,500 mg/m3/2 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
EESADV 6,19,1982
inhalation
mouse
lethal concentration (16 percent kill): 5,000 mg/m3 N/R VCVGH* -,467,1990
inhalation
mouse
lethal concentration (50 percent kill): 6,600 mg/m3 N/R VCVGH* -,467,1990
inhalation
mouse
lowest published lethal concentration: 8,100 mg/m3 N/R VCVGH* -,467,1990
inhalation
mouse
lethal concentration (84 percent kill): 8,600 mg/m3 N/R VCVGH* -,467,1990
inhalation
rat
lethal concentration (50 percent kill): 11 gm/m3/2 hour Eye: Lacrimation

Gastrointestinal: Ulceration or bleeding from duodeum

Lung, Thorax, or Respiration: Respiratory depression
EESADV 6,19,1982
inhalation
rat
lowest published lethal concentration: 20,000 mg/m3/2 hour N/R VCVGH* -,467,1990
inhalation
rat
lowest published lethal concentration: 10,000 mg/m3/4 hour N/R VCVGH* -,467,1990
inhalation
rat
lowest published toxic concentration: 1,000 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,467,1990
inhalation
rat
lethal concentration (16 percent kill): 6,400 mg/m3 N/R VCVGH* -,467,1990
inhalation
rat
lethal concentration (50 percent kill): 8,200 mg/m3 N/R VCVGH* -,467,1990
inhalation
rat
lethal concentration (84 percent kill): 10,000 mg/m3 N/R VCVGH* -,467,1990
inhalation
rabbit
lowest published lethal concentration: 22,500 mg/m3/2 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
EESADV 6,19,1982
intraperitoneal
mouse
lethal dose (50 percent kill): 155 mg/kg N/R SCCUR* -,1,1961
oral
mouse
lethal dose (50 percent kill): 425 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea
EESADV 6,19,1982
oral
mouse
lethal dose (50 percent kill): 500 mg/kg N/R VCVGH* -,468,1990
oral
rat
lethal dose (50 percent kill): 460 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea
EESADV 6,19,1982
oral
rat
lethal dose (50 percent kill): 450 mg/kg N/R VCVGH* -,468,1990
oral
rabbit
lethal dose (50 percent kill): 300 mg/kg N/R VCVGH* -,468,1990
skin
rabbit
lethal dose (50 percent kill): 2,066 mg/kg N/R JIHTAB 30,63,1948


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 8 ppm/7 hour/35 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
AIHAAP 20,217,1959
inhalation
rat
lowest published toxic concentration: 8 ppm/7 hour/35 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Endocrine: Changes in spleen weight
AIHAAP 20,217,1959
inhalation
rat
lowest published toxic concentration: 250 ppm/6 hour/90 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0539130
inhalation
rat
lowest published toxic concentration: 1.1 mg/m3/16 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGH* -,469,1990
inhalation
rat
lowest published toxic concentration: 9 mg/m3/180 day- continuous Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Liver: Other changes
VCVGH* -,469,1990
inhalation
rat
lowest published toxic concentration: 25 mg/m3/8 hour/75 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGH* -,469,1990
inhalation
rat
lowest published toxic concentration: 400 mg/m3/4 week- continuous Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVGH* -,470,1990
inhalation
rabbit
lowest published toxic concentration: 206 mg/m3/6 hour/13 week- intermittent Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Muscle weakness
EESADV 6,19,1982
inhalation
rabbit
lowest published toxic concentration: 8 ppm/7 hour/35 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
AIHAAP 20,217,1959
inhalation
rabbit
lowest published toxic concentration: 206 mg/m3/6 hour/13 week- intermittent Spinal Cord: Demyelination

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Muscle weakness
EESADV 6,19,1982
inhalation
rabbit
lowest published toxic concentration: 25 mg/m3/8 hour/75 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGH* -,469,1990
oral
mouse
lowest published toxic dose: 15,300 mg/kg/17 week- intermittent Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath
ANPTAL 55,125,1981
oral
rat
: 3,600 mg/kg/6 week- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOXID9 227,36,2006
oral
rat
: 1,800 mg/kg/3 week- intermittent Biochemical: Metabolism (intermediary): Lipids including transport TOXID9 227,36,2006
oral
rat
lowest published toxic dose: 3,600 mg/kg/6 week- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Behavioral: Muscle weakness
TXCYAC 231,58,2007
subcutaneous
rat
lowest published toxic dose: 9,949 mg/kg/13 week- intermittent Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve
ENVRAL 63,229,1993
subcutaneous
rat
lowest published toxic dose: 1,350 mg/kg/9 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Ca
ZYYZEW 3,293,1989
subcutaneous
rat
lowest published toxic dose: 5,100 mg/kg/12 week- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 191,33,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm;short term exposure limit 2 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 36,39,1985
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 71,1231,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 36,39,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,1231,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1231,1999
TOXICOLOGY REVIEW
EVHPAZ 21,251,1977
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,347,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (3 mg/m3) DTLVS* 3,8,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 ppm (3 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (3 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (3 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 ppm (3 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (3 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (3 mg/m3), short term exposure limit 3 ppm (9 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (3 mg/m3), continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 3 mg/m3, short term exposure limit 3 mg/m3, SEP2000
Occupational Exposure Limit - INDIA time-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - KOREA time-weighted average 1 ppm (3 mg/m3), short term exposure limit 2 ppm (6 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 1 ppm (3 mg/m3);
short term exposure limit 2 ppm, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 1 ppm (3 mg/m3);
short term exposure limit 2 ppm (6 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (3 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (3 mg/m3);
short term exposure limit 3 ppm (9 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (3 mg/m3);
KZG- week 1 ppm (3 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ALLYL CHLORIDE-air 10 hour time-weighted average 1 ppm;
short term exposure limit 3 ppm
NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3205;
Number of Industries 10;
Total Number of Facilities 159;
Number of Occupations 15;
Total Number of Employees Exposed 3,193;
Total Number of Female Employees Exposed 325


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: E coli polA without S9; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Allyl chloride, 1000
NCI Carcinogenesis Bioassay (gavage);equivocal evidence:mouse NCITR* NCI-TR-73,1978
NCI Carcinogenesis Bioassay (gavage);no evidence:rat NCITR* NCI-TR-73,1978


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
ANPTAL Acta Neuropathologica. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1961-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986-

Used as a chemical intermediate

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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