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Propane, 1,2 - dibromo - 3 - chloro -

RTECS #: TX8750000

CAS #: 96-12-8


UPDATE: May 2009 MW: 236.35 MF: C3H5Br2Cl


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. (R/S) - 1,2 - Dibromo - 3 - chloropropane
  2. 1,2 - Dibrom - 3 - chlor - propan (German)
  3. 1,2 - Dibromo - 3 - chloropropane
  4. 1,2 - Dibromo - 3 - chloropropane (DOT:OSHA)
  5. 1,2 - Dibromo - 3 - chloropropane production - grade
  6. 1,2 - Dibromo - 3 - cloro - propano (Italian)
  7. 1,2 - Dibroom - 3 - chloorpropaan (Dutch)
  8. 1 - Chloro - 2,3 - dibromopropane
  9. 3 - Chloro - 1,2 - dibromopropane
  10. BBC 12
  11. DBCP
  12. Dibromchlorpropan (German)
  13. Dibromochloropropane
  14. Fumagon
  15. Fumazone
  16. Fumazone 86
  17. Fumazone 86E
  18. NCI - C00500
  19. Nemabrom
  1. Nemafume
  2. Nemagon
  3. Nemagon 20
  4. Nemagon 206
  5. Nemagon 20G
  6. Nemagon 90
  7. Nemagon soil fumigant
  8. Nemagone
  9. Nemanax
  10. Nemapaz
  11. Nemaset
  12. Nematocide
  13. Nematox
  14. Nemazon
  15. OS 1897
  16. Oxy DBCP
  17. Propane, 1 - chloro - 2,3 - dibromo -
  18. RCRA waste number U066
  19. SD 1897


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
1% mild TXAPA9 3,545,1961
skin
rabbit
10 gm severe TXAPA9 3,545,1961


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 50 mg/L SCIEAS 236,933,1987
cytogenetic analysis hamster lung 200 mol/L MUREAV 78,177,1980
cytogenetic analysis oral
rat
3,650 g/kg/5 day TXAPA9 48,A46,1979
dominant lethal test oral
rat
50 mg/kg/5 day- continuous MUREAV 77,71,1980
DNA damage intraperitoneal
guinea pig
40.2 mg/kg TXCYAC 58,133,1989
DNA damage intraperitoneal
mouse
100 mg/kg MUREAV 419,13,1998
DNA damage rat testis 173 mg/L CBTOE2 1(3),181,1985
DNA damage intraperitoneal
rat
35 mg/kg CBTOE2 1(3),181,1985
DNA damage intraperitoneal
rat
1,182 g/kg CRTOEC 4,528,1991
DNA damage rat liver 5 mol/L CRNGDP 10,49,1989
DNA damage rabbit other cell types 300 mol/L MUREAV 285,303,1993
DNA damage rabbit other cell types 30 mol/L MUREAV 285,303,1993
DNA inhibition human HeLa cell 10 mmol/L MUREAV 92,427,1982
DNA repair Escherichia coli 20,900 g/disc BECTA6 14,8,1975
unscheduled DNA synthesis intraperitoneal
mouse
100 mg/kg MUREAV 68,169,1979
unscheduled DNA synthesis intraperitoneal
rat
150 mg/kg MUREAV 203,135,1988
mutation in microorganisms Bacillus subtilis 1 nmol/plate (-enzymatic activation step) MSERDS 5,93,1981
mutation in microorganisms mouse lymphocyte 20 mg/L (+enzymatic activation step) CBTOE2 3,391,1987
mutation in microorganisms Salmonella typhimurium 10 nL/well (+enzymatic activation step) STEVA8 11,223,1979
mutation in microorganisms Salmonella typhimurium 500 ng/plate (-enzymatic activation step) ENMUDM 7(Suppl 3),15,1985
mutation in microorganisms Salmonella typhimurium 100 mg/L/2 hour (+enzymatic activation step) EMMUEG 44,329,2004
mutation in microorganisms Salmonella typhimurium 200 mg/L/2 hour (-enzymatic activation step) EMMUEG 44,329,2004
micronucleus test intraperitoneal
mouse
50 mg/kg MUREAV 389,3,1997
micronucleus test oral
mouse
51.4 mg/kg/2 day- intermittent GISAAA 12,41,1993
micronucleus test oral
mouse
20.4 mg/kg/4 day- intermittent GISAAA 12,41,1993
micronucleus test oral
rat
75 mg/kg MUREAV 234,129,1990
micronucleus test oral
rat
12.68 mg/kg/4 day- intermittent GISAAA 12,41,1993
mutation in mammalian somatic cells mouse lymphocyte 83,700 g/L SCIEAS 236,933,1987
morphological transform hamster embryo 7 mg/L CBTOE2 3,391,1987
other mutation test systems Escherichia coli 50 mg/L MUREAV 131,101,1984
sister chromatid exchange hamster ovary 10 mg/L SCIEAS 236,933,1987
sister chromatid exchange hamster lung 500 mol/L MUREAV 78,177,1980
sex chromosome loss and nondisjunction inhalation
Drosophila melanogaster
17,700 ppb/3 hour- continuous ENMUDM 4,681,1982
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
100 ppm/3 day HCKHDV 5(5),7,1984
specific locus test intraperitoneal
mouse
106 mg/kg MUREAV 174,145,1986
sperm morphology oral
rat
3,650 g/kg/5 day TXAPA9 48,A46,1979
sperm morphology oral
rabbit
375 mg/kg/10 week- intermittent FAATDF 6,628,1986
heritable translocation test oral
Drosophila melanogaster
200 ppm ENMUDM 7,349,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 10 ppm/6 hour (4 week male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 3,104,1983
inhalation
rat
lowest published toxic concentration: 1 ppm/6 hour (4 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) FAATDF 3,104,1983
inhalation
rabbit
lowest published toxic concentration: 1 ppm/6 hour (70 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
FAATDF 2,241,1982
inhalation
rabbit
lowest published toxic concentration: 10 ppm/6 hour (40 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) FAATDF 2,241,1982
intraperitoneal
rat
lowest published toxic dose: 20,090 g/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male

Reproductive: Specific developmental abnormalities: Urogenital system
CRTOEC 4,528,1991
oral
mouse
lowest published toxic dose: 875 mg/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) NTIS** #PB85118644/AS
oral
mouse
lowest published toxic dose: 100 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system
NTIS** #PB85118644/AS
oral
mouse
lowest published toxic dose: 100 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system NTIS** #PB85118644/AS
oral
rat
lowest published toxic dose: 200 mg/kg (1 day male) Reproductive: Other effects on male TOXID9 4,135,1984
oral
rat
lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BECTA6 21,483,1979
oral
rat
lowest published toxic dose: 250 mg/kg (5 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
MUREAV 101,321,1982
oral
rat
lowest published toxic dose: 50 mg/kg (5 day male) Reproductive: Effects on embryo or fetus: Fetal death MUREAV 77,71,1980
oral
rat
lowest published toxic dose: 375 mg/kg (75 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
HYSAAV 36(1-3),344,1971
oral
rabbit
lowest published toxic dose: 92,657 g/kg (10 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
FAATDF 6,638,1986
subcutaneous
rat
lowest published toxic dose: 50 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ANDRDQ 23,363,1991
subcutaneous
rat
lowest published toxic dose: 33 mg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) TXAPA9 71,294,1983
subcutaneous
rat
lowest published toxic dose: 19 mg/kg (19 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TXAPA9 90,299,1987
subcutaneous
rat
lowest published toxic dose: 40 mg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 79,54,1985
subcutaneous
rat
lowest published toxic dose: 1 mg/kg (24 week male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) BIREBV 31,454,1984
unreported route
rat
lowest published toxic dose: 100 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) GISAAA 40(6),101,1975
unreported route
rat
lowest published toxic dose: 150 mg/kg (14-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
HBPTO* 1,737,2001
unreported route
rat
lowest published toxic dose: 150 mg/kg (16-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
HBPTO* 1,737,2001
unreported route
rat
lowest published toxic dose: 150 mg/kg (18-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
HBPTO* 1,737,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 600 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
JCROD7 98,75,1980
inhalation
mouse
toxic concentration (other than lowest) : 3 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
JCROD7 98,75,1980
inhalation
mouse
toxic concentration (other than lowest) : 600 ppb/6 hour/76 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
EVHPAZ 47,365,1983
inhalation
mouse
toxic concentration (other than lowest) : 600 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-206,1982
inhalation
mouse
toxic concentration (other than lowest) : 3 ppm/6 hour/76 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-206,1982
inhalation
mouse
lowest published toxic concentration: 136.8 mg/kg/76 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma
NTIS** PB82-225632
inhalation
mouse
lowest published toxic concentration: 37.08 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
NTIS** PB82-225632
inhalation
rat
lowest published toxic concentration: 600 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
BJCAAI 42,772,1980
inhalation
rat
toxic concentration (other than lowest) : 600 ppb/6 hour/76 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors
EVHPAZ 47,365,1983
inhalation
rat
toxic concentration (other than lowest) : 3 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
BJCAAI 42,772,1980
inhalation
rat
toxic concentration (other than lowest) : 600 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors
NTPTR* NTP-TR-206,1982
inhalation
rat
toxic concentration (other than lowest) : 3 ppm/6 hour/84 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors
NTPTR* NTP-TR-206,1982
inhalation
rat
lowest published toxic concentration: 18.54 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors
NTIS** PB82-225632
inhalation
rat
lowest published toxic concentration: 15.45 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Olfaction: Tumors

Endocrine: Adrenal cortex tumors
NTIS** PB82-225632
oral
mouse
lowest published toxic dose: 49 gm/kg/47 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
NCITR* NCI-TR-28,1978
oral
rat
lowest published toxic dose: 5,475 mg/kg/73 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
NCITR* NCI-TR-28,1978
oral
rat
toxic dose : 9,280 mg/kg/64 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Skin and Appendages: Tumors
NCITR* NCI-TR-28,1978
subcutaneous
rat
lowest published toxic dose: 240 mg/kg/12 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
TOLED5 31(Suppl),202,1986
subcutaneous
rat
toxic dose : 240 mg/kg/12 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
TOLED5 31(Suppl),202,1986
skin
mouse
lowest published toxic dose: 100 gm/kg/74 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
JJIND8 63,1433,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 103 ppm/8 hour N/R FEPRA7 15,448,1956
inhalation
rat
lethal concentration (50 percent kill): 98 mg/m3/4 hour N/R VCVGH* -,654,1990
intraperitoneal
guinea pig
lowest published lethal dose: 40 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 58,133,1989
intraperitoneal
hamster
lowest published lethal dose: 161 mg/kg N/R TXCYAC 58,133,1989
intraperitoneal
mouse
lethal dose (50 percent kill): 123 mg/kg N/R MUREAV 68,169,1979
intraperitoneal
mouse
lowest published toxic dose: 80.4 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 58,133,1989
intraperitoneal
mouse
lowest published lethal dose: 120 mg/kg N/R TXCYAC 58,133,1989
intraperitoneal
rat
lowest published toxic dose: 40.2 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 58,133,1989
intraperitoneal
rat
lowest published lethal dose: 80.4 mg/kg N/R TXCYAC 58,133,1989
intraperitoneal
rat
lowest published toxic dose: 40 mg/kg Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
CHIRA* 7,359,1995
oral
chicken
lethal dose (50 percent kill): 60 mg/kg N/R VCVGH* -,654,1990
oral
guinea pig
lethal dose (50 percent kill): 150 mg/kg N/R PCOC** -,797,1966
oral
mouse
lethal dose (50 percent kill): 257 mg/kg N/R GUCHAZ 6,172,1973
oral
rat
lethal dose (50 percent kill): 170 mg/kg N/R TXAPA9 3,545,1961
oral
rat
lowest published toxic dose: 100 mg/kg Brain and Coverings: Recordings from specific areas of CNS VCVGH* -,654,1990
oral
rabbit
lethal dose (50 percent kill): 180 mg/kg N/R VCVGH* -,654,1990
subcutaneous
rat
lethal dose (50 percent kill): 100 mg/kg N/R TXCYAC 27,287,1983
subcutaneous
rat
lowest published toxic dose: 100 mg/kg Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXAPA9 59,84,1981
subcutaneous
rat
lowest published toxic dose: 250 mg/kg Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBPTO* 1,881,2001
skin
rabbit
lethal dose (50 percent kill): 1,400 mg/kg N/R TXAPA9 3,545,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic dose: 12 ppm/7 hour/70 day- intermittent Related to Chronic Data: Changes in testicular weight TXAPA9 3,545,1961
inhalation
mouse
lowest published toxic concentration: 5 ppm/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-206,1982
inhalation
rat
lowest published toxic dose: 10 ppm/7 hour/70 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TXAPA9 3,545,1961
inhalation
rat
lowest published toxic concentration: 25 ppm/6 hour/13 week- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in bone marrow not included in above
NTPTR* NTP-TR-206,1982
inhalation
rat
lowest published toxic concentration: 10 ppm/24 hour/14 day- continuous Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
INHEAO 20,315,1982
inhalation
rat
lowest published toxic dose: 12 ppm/7 hour/70 day- intermittent Related to Chronic Data: Changes in testicular weight TXAPA9 3,545,1961
intraperitoneal
rat
lowest published toxic dose: 160 mg/kg/2 day- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Other changes
TOLED5 8,317,1981
oral
mouse
lowest published toxic dose: 11,940 mg/kg/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NCITR* NCI-TR-28,1978
oral
rat
lowest published toxic dose: 3,150 mg/kg/45 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Blood: Changes in spleen
MZUZA8 1(1),64,1970
oral
rat
lowest published toxic dose: 2,025 mg/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 3,545,1961
oral
rat
lowest published toxic dose: 602 mg/kg/64 day- continuous Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
FAATDF 13,804,1989
parenteral
rat
lowest published toxic dose: 350 mg/kg/4 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
REPTED 17,263,2003
parenteral
rat
lowest published toxic dose: 350 mg/kg/4 day- intermittent Endocrine: Change in LH

Endocrine: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
REPTED 17,263,2003
parenteral
rat
lowest published toxic dose: 400 mg/kg/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 17,263,2003
parenteral
rat
lowest published toxic dose: 350 mg/kg/4 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
TOXID9 1,72,2001
subcutaneous
rat
lowest published toxic dose: 2,400 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in leukocyte (WBC) count

Related to Chronic Data: Changes in testicular weight
INHEAO 27,49,1989
subcutaneous
rat
lowest published toxic dose: 175 mg/kg/1 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BIREBV 31,454,1984
subcutaneous
rat
lowest published toxic dose: 912.5 mg/kg/26 week- intermittent Endocrine: Change in LH

Related to Chronic Data: Changes in testicular weight
BIREBV 31,454,1984
subcutaneous
rat
lowest published toxic dose: 4,562 mg/kg/26 week- intermittent Endocrine: Change in gonadotropins

Related to Chronic Data: Changes in prostate weight
BIREBV 31,454,1984
subcutaneous
rat
lowest published toxic dose: 912.5 mg/kg/26 week- intermittent Related to Chronic Data: Changes in testicular weight BIREBV 31,454,1984
subcutaneous
rat
lowest published toxic dose: 182.5 mg/kg/26 week- intermittent Endocrine: Androgenic BIREBV 31,454,1984
subcutaneous
rat
lowest published toxic dose: 240 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
INHEAO 27,49,1989
subcutaneous
rat
lowest published toxic dose: 540 mg/kg/9 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain INHEAO 27,49,1989
subcutaneous
rat
lowest published toxic dose: 1,920 mg/kg/32 week- intermittent Tumorigenic: Tumors at site of application INHEAO 27,49,1989
subcutaneous
rat
lowest published toxic dose: 2,160 mg/kg/36 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) INHEAO 27,49,1989
subcutaneous
rat
lowest published toxic dose: 400 mg/kg/2 week- intermittent Skin and Appendages: Other: Hair INHEAO 27,49,1989
subcutaneous
rat
lowest published toxic dose: 600 mg/kg/3 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain INHEAO 27,49,1989
subcutaneous
rat
lowest published toxic dose: 2,400 mg/kg/12 week- intermittent Blood: Luekopenia

Kidney, Ureter, and Bladder: Other changes in urine composition

Related to Chronic Data: Changes in testicular weight
INHEAO 27,49,1989
subcutaneous
rat
lowest published toxic dose: 6,000 mg/kg/30 week- intermittent Tumorigenic: Tumors at site of application INHEAO 27,49,1989
subcutaneous
rat
lowest published toxic dose: 7,200 mg/kg/36 week- intermittent Blood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count
INHEAO 27,49,1989
subcutaneous
rat
lowest published toxic dose: 350 mg/kg/4 day- intermittent Endocrine: Change in gonadotropins

Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TOSCF2 76,418,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 20,83,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 15,139,1977
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,479,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,191,1987
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,479,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,479,1999
TOXICOLOGY REVIEW
TOLED5 127,135,2002
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
TOLED5 134,17,2002
TOXICOLOGY REVIEW
TOLED5 135,167,2002
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
ENTOX* -,546,2005
TOXICOLOGY REVIEW
ENTOX* -,793,2005
TOXICOLOGY REVIEW
ENTOX* -,193,2005
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
JTPAE7 17,69,2004
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
MUREAV 681,3,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see Code of Federal Regulations (CFR) 29,1926.1144 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) cancer hazard CFRGBR 29,1910.1044,1987
Occupational Exposure Limit - DENMARK time-weighted average 0.001 ppm (0.01 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY ceiling concentration 0.01 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - SWEDEN Group A Carcinogen, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2-DIBROMO-3-CHLOROPROPANE-air Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1044 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2705;
Number of Industries 1;
Total Number of Facilities 8;
Number of Occupations 6;
Total Number of Employees Exposed 176


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; Sperm morphology-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a soil fumigant for control of nematodes
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:rat
NTP Carcinogenesis Bioassay (inhalation);clear evidence:mouse,rat NTPTR* NTP-TR-206,1982
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE

ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHIRA* Chirality. (New York Ny Wiley-Liss) V.1- 1989-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HCKHDV Huanjing Kexue. Environmental Sciences. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1976- Adopted vol. no. with Vol. 1, 1980.
HTOPA*
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93- 1979-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MSERDS Microbiology Series. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1973-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1957-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
STEVA8 Science of the Total Environment. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1972-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as a soil fumigant for control of nematodes

NIOSH PROFILE (ALIPHATICS, BROMINATED), SRI, 2/77

NIOSH PROFILE (FUMIGANTS), SRC, 10/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 105567-86-0
Click Here for Additional Information about RTECS

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