Propane, 1,2-dibromo-3-chloro-

RTECS #

TX8750000

CAS #

96-12-8; 105567-86-0
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

236.35

Molecular Formula

C₃H₅Br₂Cl

Synonyms

(R/S)-1,2-Dibromo-3-chloropropane
1,2-Dibrom-3-chlor-propan (German)
1,2-Dibromo-3-chloropropane
1,2-Dibromo-3-chloropropane (DOT:OSHA)
1,2-Dibromo-3-chloropropane production-grade
1,2-Dibromo-3-cloro-propano (Italian)
1,2-Dibroom-3-chloorpropaan (Dutch)
1-Chloro-2,3-dibromopropane
3-Chloro-1,2-dibromopropane
BBC 12
DBCP
Dibromchlorpropan (German)
Dibromochloropropane
Fumagon
Fumazone
Fumazone 86
Fumazone 86E
NCI-C00500
Nemabrom
Nemafume
Nemagon
Nemagon 20
Nemagon 206
Nemagon 20G
Nemagon 90
Nemagon soil fumigant
Nemagone
Nemanax
Nemapaz
Nemaset
Nematocide
Nematox
Nemazon
OS 1897
Oxy DBCP
Propane, 1-chloro-2,3-dibromo-
RCRA waste number U066
SD 1897

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /rabbit	1%	mild	TXAPA9 3,545,1961
skin /rabbit	10 gm	severe	TXAPA9 3,545,1961

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	oral/rat	3650 µg/kg/5D	TXAPA9 48,A46,1979
Cytogenetic Analysis	ovary/hamster	50 mg/L	SCIEAS 236,933,1987
Cytogenetic Analysis	lung/hamster	200 µmol/L	MUREAV 78,177,1980
DNA Damage	intraperitoneal/mouse	100 mg/kg	MUREAV 419,13,1998
DNA Damage	other cell types/rabbit	300 µmol/L	MUREAV 285,303,1993
DNA Damage	other cell types/rabbit	30 µmol/L	MUREAV 285,303,1993
DNA Damage	intraperitoneal/guinea pig	40.2 mg/kg	TXCYAC 58,133,1989
DNA Damage	testis/rat	173 mg/L	CBTOE2 1(3),181,1985
DNA Damage	intraperitoneal/rat	35 mg/kg	CBTOE2 1(3),181,1985
DNA Damage	intraperitoneal/rat	1182 µg/kg	CRTOEC 4,528,1991
DNA Damage	liver/rat	5 µmol/L	CRNGDP 10,49,1989
DNA inhibition	HeLa cell/human	10 mmol/L	MUREAV 92,427,1982
DNA repair	/Escherichia coli	20900 µg/disc	BECTA6 14,8,1975
Dominant Lethal Test	oral/rat	50 mg/kg/5D-continuous	MUREAV 77,71,1980
heritable translocation test	oral/Drosophila melanogaster	200 ppm	ENMUDM 7,349,1985
micronucleus test	oral/mouse	51.4 mg/kg/2D- intermittent	GISAAA 12,41,1993
micronucleus test	oral/rat	12.68 mg/kg/4D- intermittent	GISAAA 12,41,1993
micronucleus test	oral/mouse	20.4 mg/kg/4D- intermittent	GISAAA 12,41,1993
micronucleus test	oral/rat	75 mg/kg	MUREAV 234,129,1990
micronucleus test	intraperitoneal/mouse	50 mg/kg	MUREAV 389,3,1997
morphological transform	embryo/hamster	7 mg/L	CBTOE2 3,391,1987
mutation in mammalian somatic cells	lymphocyte/mouse	83700 µg/L	SCIEAS 236,933,1987
mutation in microorganisms	/Salmonella typhimurium	100 mg/L/2H (+enzymatic activation step)	EMMUEG 44,329,2004
mutation in microorganisms	/Salmonella typhimurium	200 mg/L/2H (-enzymatic activation step)	EMMUEG 44,329,2004
mutation in microorganisms	lymphocyte/mouse	20 mg/L (+enzymatic activation step)	CBTOE2 3,391,1987
mutation in microorganisms	/Salmonella typhimurium	10 nL/well (+enzymatic activation step)	STEVA8 11,223,1979
mutation in microorganisms	/Salmonella typhimurium	500 ng/plate (-enzymatic activation step)	ENMUDM 7(Suppl 3),15,1985
mutation in microorganisms	/Bacillus subtilis	1 nmol/plate (-enzymatic activation step)	MSERDS 5,93,1981
other mutation test systems	/Escherichia coli	50 mg/L	MUREAV 131,101,1984
sex chromosome loss and nondisjunction	inhalation/Drosophila melanogaster	17700 ppb/3H-continuous	ENMUDM 4,681,1982
sex chromosome loss and nondisjunction	oral/Drosophila melanogaster	100 ppm/3D	HCKHDV 5(5),7,1984
sister chromatid exchange	ovary/hamster	10 mg/L	SCIEAS 236,933,1987
sister chromatid exchange	lung/hamster	500 µmol/L	MUREAV 78,177,1980
specific locus test	intraperitoneal/mouse	106 mg/kg	MUREAV 174,145,1986
sperm morphology	oral/rat	3650 µg/kg/5D	TXAPA9 48,A46,1979
sperm morphology	oral/rabbit	375 mg/kg/10W- intermittent	FAATDF 6,628,1986
Unscheduled DNA Synthesis	intraperitoneal/mouse	100 mg/kg	MUREAV 68,169,1979
Unscheduled DNA Synthesis	intraperitoneal/rat	150 mg/kg	MUREAV 203,135,1988

Reproductive Effects Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	10 ppm/6H (4W male)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	FAATDF 3,104,1983
inhalation/rat	1 ppm/6H (4W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	FAATDF 3,104,1983
inhalation/rabbit	1 ppm/6H (70D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)	FAATDF 2,241,1982
inhalation/rabbit	10 ppm/6H (40D male)	Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	FAATDF 2,241,1982
intraperitoneal/rat	20090 µg/kg (1D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Other effects on male Reproductive: Specific developmental abnormalities: Urogenital system	CRTOEC 4,528,1991
oral/rat	200 mg/kg (1D male)	Reproductive: Other effects on male	TOXID9 4,135,1984
oral/rat	500 mg/kg (6-15D pregnant)	Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)	BECTA6 21,483,1979
oral/rat	250 mg/kg (5D male)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	MUREAV 101,321,1982
oral/rat	50 mg/kg (5D male)	Reproductive: Effects on embryo or fetus: Fetal death	MUREAV 77,71,1980
oral/rat	375 mg/kg (75D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	HYSAAV 36(1-3),344,1971
oral/rabbit	92657 µg/kg (10W male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct	FAATDF 6,638,1986
oral/mouse	875 mg/kg (7D male/7D prior to copulation/21D pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	NTIS** #PB85118644/AS
oral/mouse	100 mg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Hepatobiliary system Reproductive: Specific developmental abnormalities: Urogenital system	NTIS** #PB85118644/AS
oral/mouse	100 mg/kg (multigenerations)	Reproductive: Specific developmental abnormalities: Hepatobiliary system	NTIS** #PB85118644/AS
subcutaneous/rat	1 mg/kg (24W male)	Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	BIREBV 31,454,1984
subcutaneous/rat	50 mg/kg (1D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	ANDRDQ 23,363,1991
subcutaneous/rat	33 mg/kg (1D male)	Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)	TXAPA9 71,294,1983
subcutaneous/rat	19 mg/kg (19D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands	TXAPA9 90,299,1987
subcutaneous/rat	40 mg/kg (1D male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXAPA9 79,54,1985
unreported route/rat	100 mg/kg (1D male)	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	GISAAA 40(6),101,1975
unreported route/rat	150 mg/kg (14-19D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Delayed effects	HBPTO* 1,737,2001
unreported route/rat	150 mg/kg (16-19D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Delayed effects	HBPTO* 1,737,2001
unreported route/rat	150 mg/kg (18-19D pregnant)	Reproductive: Specific developmental abnormalities: Endocrine system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Delayed effects	HBPTO* 1,737,2001

Tumorigenic Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 600 ppb/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors	JCROD7 98,75,1980
inhalation/mouse	toxic concentration: 3 ppm/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors	JCROD7 98,75,1980
inhalation/mouse	toxic concentration: 600 ppb/6H/76W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Lung, Thorax, or Respiration: Tumors	EVHPAZ 47,365,1983
inhalation/mouse	toxic concentration: 600 ppb/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Lung, Thorax, or Respiration: Tumors	NTPTR* NTP-TR-206,1982
inhalation/mouse	toxic concentration: 3 ppm/6H/76W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Lung, Thorax, or Respiration: Tumors	NTPTR* NTP-TR-206,1982
inhalation/mouse	lowest published toxic concentration: 136.8 mg/kg/76W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma	NTIS** PB82-225632
inhalation/mouse	lowest published toxic concentration: 37.08 mg/kg/103W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors	NTIS** PB82-225632
inhalation/rat	lowest published toxic concentration: 18.54 mg/kg/103W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors	NTIS** PB82-225632
inhalation/rat	lowest published toxic concentration: 15.45 mg/kg/103W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Endocrine: Adrenal cortex tumors	NTIS** PB82-225632
inhalation/rat	toxic concentration: 600 ppb/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Endocrine: Adrenal cortex tumors	NTPTR* NTP-TR-206,1982
inhalation/rat	toxic concentration: 3 ppm/6H/84W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Endocrine: Adrenal cortex tumors	NTPTR* NTP-TR-206,1982
inhalation/rat	toxic concentration: 600 ppb/6H/76W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors Endocrine: Adrenal cortex tumors	EVHPAZ 47,365,1983
inhalation/rat	toxic concentration: 3 ppm/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors	BJCAAI 42,772,1980
inhalation/rat	lowest published toxic concentration: 600 ppb/6H/2Y- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Olfaction: Tumors	BJCAAI 42,772,1980
oral/mouse	lowest published toxic dose: 49 gm/kg/47W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors	NCITR* NCI-TR-28,1978
oral/rat	lowest published toxic dose: 5475 mg/kg/73W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Skin and Appendages: Tumors	NCITR* NCI-TR-28,1978
oral/rat	toxic dose: 9280 mg/kg/64W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Gastrointestinal: Tumors Skin and Appendages: Tumors	NCITR* NCI-TR-28,1978
skin/mouse	lowest published toxic dose: 100 gm/kg/74W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Lung, Thorax, or Respiration: Tumors Skin and Appendages: Tumors	JJIND8 63,1433,1979
subcutaneous/rat	lowest published toxic dose: 240 mg/kg/12W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application	TOLED5 31(Suppl),202,1986
subcutaneous/rat	toxic dose: 240 mg/kg/12W- intermittent	Tumorigenic: Carcinogenic by RTECS criteria Kidney, Ureter, and Bladder: Kidney tumors	TOLED5 31(Suppl),202,1986

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lethal concentration (50 percent kill): 103 ppm/8H		FEPRA7 15,448,1956
inhalation/rat	lethal concentration (50 percent kill): 98 mg/m³/4H		VCVGH* -,654,1990
intraperitoneal/guinea pig	lowest published lethal dose: 40 mg/kg	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXCYAC 58,133,1989
intraperitoneal/hamster	lowest published lethal dose: 161 mg/kg		TXCYAC 58,133,1989
intraperitoneal/mouse	lowest published toxic dose: 80.4 mg/kg	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXCYAC 58,133,1989
intraperitoneal/mouse	lowest published lethal dose: 120 mg/kg		TXCYAC 58,133,1989
intraperitoneal/mouse	lethal dose (50 percent kill): 123 mg/kg		MUREAV 68,169,1979
intraperitoneal/rat	lowest published toxic dose: 40.2 mg/kg	Reproductive: Paternal effects: Testes, epididymis, sperm duct	TXCYAC 58,133,1989
intraperitoneal/rat	lowest published lethal dose: 80.4 mg/kg		TXCYAC 58,133,1989
intraperitoneal/rat	lowest published toxic dose: 40 mg/kg	Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	CHIRA* 7,359,1995
oral/chicken	lethal dose (50 percent kill): 60 mg/kg		VCVGH* -,654,1990
oral/guinea pig	lethal dose (50 percent kill): 150 mg/kg		PCOC** -,797,1966
oral/mouse	lethal dose (50 percent kill): 257 mg/kg		GUCHAZ 6,172,1973
oral/rabbit	lethal dose (50 percent kill): 180 mg/kg		VCVGH* -,654,1990
oral/rat	lowest published toxic dose: 100 mg/kg	Brain and Coverings: Recordings from specific areas of CNS	VCVGH* -,654,1990
oral/rat	lethal dose (50 percent kill): 170 mg/kg		TXAPA9 3,545,1961
skin/rabbit	lethal dose (50 percent kill): 1400 mg/kg		TXAPA9 3,545,1961
subcutaneous/rat	lethal dose (50 percent kill): 100 mg/kg		TXCYAC 27,287,1983
subcutaneous/rat	lowest published toxic dose: 250 mg/kg	Kidney, Ureter, and Bladder: Other changes Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain	HBPTO* 1,881,2001
subcutaneous/rat	lowest published toxic dose: 100 mg/kg	Kidney, Ureter, and Bladder: Changes in kidney weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	TXAPA9 59,84,1981

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic dose: 12 ppm/7H/70D- intermittent	Related to Chronic Data: Changes in testicular weight	TXAPA9 3,545,1961
inhalation/mouse	lowest published toxic concentration: 5 ppm/6H/13W- intermittent	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NTPTR* NTP-TR-206,1982
inhalation/rat	lowest published toxic dose: 12 ppm/7H/70D- intermittent	Related to Chronic Data: Changes in testicular weight	TXAPA9 3,545,1961
inhalation/rat	lowest published toxic dose: 10 ppm/7H/70D- intermittent	Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	TXAPA9 3,545,1961
inhalation/rat	lowest published toxic concentration: 25 ppm/6H/13W- intermittent	Liver: Hepatitis (hepatocellular necrosis), zonal Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Changes in bone marrow not included in above	NTPTR* NTP-TR-206,1982
inhalation/rat	lowest published toxic concentration: 10 ppm/24H/14D- continuous	Lung, Thorax, or Respiration: Other changes Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	INHEAO 20,315,1982
intraperitoneal/rat	lowest published toxic dose: 160 mg/kg/2D- intermittent	Kidney, Ureter, and Bladder: Other changes Blood: Other changes	TOLED5 8,317,1981
oral/mouse	lowest published toxic dose: 11940 mg/kg/6W- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	NCITR* NCI-TR-28,1978
oral/rat	lowest published toxic dose: 3150 mg/kg/45D- intermittent	Liver: Hepatitis (hepatocellular necrosis), diffuse Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring) Blood: Changes in spleen	MZUZA8 1(1),64,1970
oral/rat	lowest published toxic dose: 2025 mg/kg/90D- continuous	Liver: Changes in liver weight Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain	TXAPA9 3,545,1961
oral/rat	lowest published toxic dose: 602 mg/kg/64D- continuous	Behavioral: Fluid intake Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	FAATDF 13,804,1989
parenteral/rat	lowest published toxic dose: 350 mg/kg/4D- intermittent	Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	TOXID9 1,72,2001
parenteral/rat	lowest published toxic dose: 350 mg/kg/4D- intermittent	Reproductive: Paternal effects: Testes, epididymis, sperm duct Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight	REPTED 17,263,2003
parenteral/rat	lowest published toxic dose: 350 mg/kg/4D- intermittent	Endocrine: Change in LH Endocrine: Other changes Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)	REPTED 17,263,2003
parenteral/rat	lowest published toxic dose: 400 mg/kg/4D- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	REPTED 17,263,2003
subcutaneous/rat	lowest published toxic dose: 350 mg/kg/4D- intermittent	Endocrine: Change in gonadotropins Endocrine: Androgenic Reproductive: Paternal effects: Testes, epididymis, sperm duct	TOSCF2 76,418,2003
subcutaneous/rat	lowest published toxic dose: 2400 mg/kg/12W- intermittent	Kidney, Ureter, and Bladder: Changes in bladder weight Blood: Changes in leukocyte (WBC) count Related to Chronic Data: Changes in testicular weight	INHEAO 27,49,1989
subcutaneous/rat	lowest published toxic dose: 175 mg/kg/1W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	BIREBV 31,454,1984
subcutaneous/rat	lowest published toxic dose: 912.5 mg/kg/26W- intermittent	Endocrine: Change in LH Related to Chronic Data: Changes in testicular weight	BIREBV 31,454,1984
subcutaneous/rat	lowest published toxic dose: 4562 mg/kg/26W- intermittent	Endocrine: Change in gonadotropins Related to Chronic Data: Changes in prostate weight	BIREBV 31,454,1984
subcutaneous/rat	lowest published toxic dose: 912.5 mg/kg/26W- intermittent	Related to Chronic Data: Changes in testicular weight	BIREBV 31,454,1984
subcutaneous/rat	lowest published toxic dose: 182.5 mg/kg/26W- intermittent	Endocrine: Androgenic	BIREBV 31,454,1984
subcutaneous/rat	lowest published toxic dose: 240 mg/kg/12W- intermittent	Kidney, Ureter, and Bladder: Changes in kidney weight Reproductive: Paternal effects: Testes, epididymis, sperm duct	INHEAO 27,49,1989
subcutaneous/rat	lowest published toxic dose: 540 mg/kg/9W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	INHEAO 27,49,1989
subcutaneous/rat	lowest published toxic dose: 1920 mg/kg/32W- intermittent	Tumorigenic: Tumors at site of application	INHEAO 27,49,1989
subcutaneous/rat	lowest published toxic dose: 2160 mg/kg/36W- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	INHEAO 27,49,1989
subcutaneous/rat	lowest published toxic dose: 400 mg/kg/2W- intermittent	Skin and Appendages: Other: Hair	INHEAO 27,49,1989
subcutaneous/rat	lowest published toxic dose: 600 mg/kg/3W- intermittent	Nutritional and Gross Metabolic: Weight loss or decreased weight gain	INHEAO 27,49,1989
subcutaneous/rat	lowest published toxic dose: 2400 mg/kg/12W- intermittent	Blood: Luekopenia Kidney, Ureter, and Bladder: Other changes in urine composition Related to Chronic Data: Changes in testicular weight	INHEAO 27,49,1989
subcutaneous/rat	lowest published toxic dose: 6000 mg/kg/30W- intermittent	Tumorigenic: Tumors at site of application	INHEAO 27,49,1989
subcutaneous/rat	lowest published toxic dose: 7200 mg/kg/36W- intermittent	Blood: Normocytic anemia Blood: Changes in leukocyte (WBC) count	INHEAO 27,49,1989

Reviews

Organization	Standard	Reference
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 20,83,1979
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 15,139,1977
International Agency for Research on Cancer (IARC)	Cancer Review:Animal Sufficient Evidence	IMEMDT 71,479,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMSUDL 7,191,1987
International Agency for Research on Cancer (IARC)	Cancer Review:Human Inadequate Evidence	IMEMDT 71,479,1999
International Agency for Research on Cancer (IARC)	Cancer Review:Group 2B	IMEMDT 71,479,1999
TOXICOLOGY REVIEW		FAATDF 13,747,1989
TOXICOLOGY REVIEW		TOLED5 127,135,2002
TOXICOLOGY REVIEW		TOLED5 134,17,2002
TOXICOLOGY REVIEW		TOLED5 135,167,2002
TOXICOLOGY REVIEW		MUREAV 567,347,2004
TOXICOLOGY REVIEW		ENTOX* -,546,2005
TOXICOLOGY REVIEW		ENTOX* -,793,2005
TOXICOLOGY REVIEW		ENTOX* -,193,2005
TOXICOLOGY REVIEW		BCLPT* 96,131,2005
TOXICOLOGY REVIEW		JTEHD6 7,1,2004
TOXICOLOGY REVIEW		JTPAE7 17,69,2004
TOXICOLOGY REVIEW		HTOPA* 1,501,2002
TOXICOLOGY REVIEW		MUREAV 681,3,2009
TOXICOLOGY REVIEW		MUREAV 590,1,2005
TOXICOLOGY REVIEW		REPTED 26,13,2008
TOXICOLOGY REVIEW		MUREAV 751,49,2012
TOXICOLOGY REVIEW		REPTED 33,269,2012
TOXICOLOGY REVIEW		MUREAV 769,34,2014
TOXICOLOGY REVIEW		MUREAV 783,66,2015
TOXICOLOGY REVIEW		TXCYAC 307,3,2013
TOXICOLOGY REVIEW		TOLED5 230,146,2014
TOXICOLOGY REVIEW		MUREAV 802,1,2016
TOXICOLOGY REVIEW		MUTAEX 31,347,2016
TOXICOLOGY REVIEW		MUREAV 832-833,7,2018

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit-DENMARK	time-weighted average 0.001 ppm (0.01 mg/m³), carc, MAY2011
Occupational Exposure Limit-HUNGARY	ceiling concentration 0.01 mg/m³, Carcinogen, SEP2000
Occupational Exposure Limit-ICELAND	time-weighted average 0.001 ppm (0.01 mg/m³), carc, NOV2011
Occupational Exposure Limit-JAPAN	2B carc, MAY2012
Occupational Exposure Limit-SWEDEN	Group A Carcinogen, JUN2005
Occupational Exposure Limit-SWITZERLAND	carc 2, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	see Code of Federal Regulations (CFR) 29,1926.1144	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA)-cancer hazard		CFRGBR 29,1910.1044,1987

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,2-DIBROMO-3-CHLOROPROPANE-air	Carcinogen use 29 Code of Federal Regulations (CFR) 1910.1044	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	Hazard Code M2705; Number of Industries 1; Total Number of Facilities 8; Number of Occupations 6; Total Number of Employees Exposed 176

Status in Federal Agencies

Organization	Reference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; Sperm morphology-human
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE	FEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);clear evidence:rat
NTP 14th Report on Carcinogens,2016:Reasonably anticipated to be human carcinogen
NTP Carcinogenesis Bioassay (inhalation);clear evidence:mouse,rat NTPTR* NTP-TR-206,1982
On EPA IRIS database

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health