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Propane, 1 - butoxy - 2,3 - epoxy -

RTECS #: TX4200000

CAS #: 2426-08-6


UPDATE: May 2009 MW: 130.21 MF: C7H14O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2,3 - Epoxypropyl butyl ether
  2. Ageflex BGE
  3. BGE (OSHA)
  4. Butyl glycidyl ether
  5. Ether, butyl 2,3 - epoxypropyl
  6. Ether, butyl glycidyl
  1. Glycidyl butyl ether
  2. Oxirane, (butoxymethyl) - (9CI)
  3. TK 10408
  4. n - Butyl glycidyl ether
  5. n - Butyl glycidyl ether (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
91 mg mild AMIHAB 14,250,1956
eye
rabbit
750 Ág/24 hour severe 85JCAE -,774,1986
skin
rabbit
454 mg/3 day mild AMIHAB 14,250,1956
skin
rabbit
20 mg/24 hour moderate 85JCAE -,774,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage Escherichia coli 1 Ámol/L ARTODN 46,277,1980
mutation in microorganisms Escherichia coli 20 Ámol/L (-enzymatic activation step) ARTODN 46,277,1980
mutation in microorganisms Salmonella typhimurium 10 mg/plate (+/-enzymatic activation step) MUREAV 66,367,1979
micronucleus test intraperitoneal
mouse
675 mg/kg ENMUDM 2,521,1980
other mutation test systems Escherichia coli 1 mmol/L MUREAV 231,205,1990
sister chromatid exchange hamster lung 2,500 Ámol/L MUREAV 249,55,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 36 gm/kg (24 day male) Reproductive: Effects on embryo or fetus: Fetal death MUREAV 124,225,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 260 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 51(8),91,1986
inhalation
rat
lethal concentration (50 percent kill): 1,030 ppm/8 hour Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Lung, Thorax, or Respiration: Dyspnea
AMIHAB 14,250,1956
intraperitoneal
mouse
lethal dose (50 percent kill): 700 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
intraperitoneal
rat
lethal dose (50 percent kill): 1,140 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
oral
mouse
lethal dose (50 percent kill): 1,530 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia
AMIHAB 14,250,1956
oral
rat
lethal dose (50 percent kill): 1,660 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
GISAAA 51(8),91,1986
skin
rat
lethal dose (50 percent kill): >2,150 mg/kg N/R TSCAT* OTS0515483
skin
rabbit
lethal dose (50 percent kill): 2,520 ÁL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 3 ppm (skin, sen) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (270 mg/m3) DTLVS* 3,33,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (270 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (270 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (270 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (270 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (133 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 3 ppm (16.2 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 6 ppm (30 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 25 ppm (135 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (135 mg/m3), continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 25 ppm (135 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 25 ppm (135 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 135 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 25 ppm (133 mg/m3), sen, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (270 mg/m3), JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (50 mg/m3);
short term exposure limit 15 ppm (80 mg/m3), Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (135 mg/m3);
KZG- week 50 ppm (270 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (270 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 3 ppm (skin, sen)
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 3 ppm (skin, sen)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BUTYL GLYCIDYL ETHER-air ceiling concentration 5.6 ppm/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 14720;
Number of Industries 37;
Total Number of Facilities 1,596;
Number of Occupations 45;
Total Number of Employees Exposed 19,839
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 14720;
Number of Industries 56;
Total Number of Facilities 2,593;
Number of Occupations 57;
Total Number of Employees Exposed 60,217;
Total Number of Female Employees Exposed 14,929


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as reactive diluent for epoxy resins, flooring, laminating, and electrical
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8718;8EHQ-0892-9000
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
NIOSH Analytical Method, 1994: n-Butyl glycidyl ether, 1616


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)

Used as reactive diluent for epoxy resins, flooring, laminating, and electrical

NIOSH PROFILE (EPOXY COMPOUNDS), SRC, 2/82

NIOSH PROFILE (ETHERS, GLYCIDYL), SRC, 10/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

Click Here for Additional Information about RTECS

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