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Phthalic acid, dibutyl ester

RTECS #: TI0875000

CAS #: 84-74-2


UPDATE: May 2009 MW: 278.38 MF: C16H22O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Benzene - o - dicarboxylic acid di - n - butyl ester
  2. Celluflex DPB
  3. DBP (ester)
  4. Di - n - butylester kyseliny ftalove (Czech)
  5. Di - n - butyl phthalate
  6. Dibutyl 1,2 - benzenedicarboxylate
  7. Dibutyl phthalate
  8. Dibutyl phthalate (ACGIH:OSHA)
  9. Dibutyl o - phthalate
  10. Elaol
  11. Ergoplast FOB
  12. Genoplast B
  13. Hatcol DBP
  1. Hexaplas M/B
  2. Kodaflex DBP
  3. Monocizer DBP
  4. PX 104
  5. Palatinol C
  6. Polycizer DBP
  7. RCRA waste number U069
  8. Staflex DBP
  9. Unimoll DB
  10. Vestinol C
  11. Witcizer 300
  12. n - Butylphthalate
  13. o - Benzenedicarboxylic acid, dibutyl ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster fibroblast 30 mg/L/24 hour MUREAV 48,337,1977
DNA damage human lymphocyte 354 mmol/L MUREAV 467,21,2000
DNA damage human other cell types 354 mmol/L MUREAV 467,21,2000
DNA damage human other cell types 216 mol/L/60 minute EMMUEG 35,9,2000
DNA damage human lymphocyte 354 mmol/L/60 minute TCMUD8 21,189,2001
mutation in microorganisms Salmonella typhimurium 100 g/plate (+enzymatic activation step) JTEHD6 16,61,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 1,017 mg/kg (5-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JPMSAE 61,51,1972
intraperitoneal
rat
lowest published toxic dose: 305 mg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JPMSAE 61,51,1972
intraperitoneal
rat
lowest published toxic dose: 6 gm/kg (3-9 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) EVHPAZ 3,91,1973
intraperitoneal
rat
lowest published toxic dose: 6 mL/kg (3-9 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) EVHPAZ 3,91,1973
oral
guinea pig
lowest published toxic dose: 14 gm/kg (7 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TOLED5 11,141,1982
oral
mouse
lowest published toxic dose: 7,200 mg/kg (1-18 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Central nervous system
OEKSDJ 8,29,1977
oral
mouse
lowest published toxic dose: 8,640 mg/kg (1-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) EVHPAZ 45,65,1982
oral
mouse
lowest published toxic dose: 20 gm/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TCMUD8 7,29,1987
oral
mouse
lowest published toxic dose: 16,800 mg/kg (7 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male
TOLED5 5,413,1980
oral
mouse
lowest published toxic dose: 46,200 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ENVRAL 22,245,1980
oral
rat
lowest published toxic dose: 24 gm/kg (20 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
WDZAEK 3,153,1989
oral
rat
lowest published toxic dose: 6,750 mg/kg (0-8 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
CGANE7 39,189,1999
oral
rat
lowest published toxic dose: 2,250 mg/kg (7-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TXCYAC 86,163,1994
oral
rat
lowest published toxic dose: 2,520 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) TXAPA9 26,253,1973
oral
rat
lowest published toxic dose: 8,820 mg/kg (7-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TOLED5 69,197,1993
oral
rat
lowest published toxic dose: 19 gm/kg (3-22 day pregnant/3-20 day after birth) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
TOSCF2 43,47,1998
oral
rat
lowest published toxic dose: 1,500 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JJATDK 17,223,1997
oral
rat
lowest published toxic dose: 6,750 mg/kg (0-8 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
REPTED 14,13,2000
oral
rat
lowest published toxic dose: 2 gm/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Sex ratio
TOSCF2 45,212,1998
oral
rat
lowest published toxic dose: 1.5 gm/kg (15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TOSCF2 45,212,1998
oral
rat
lowest published toxic dose: 501 mg/kg (10 day pregnant) Reproductive: Other effects to embryo or fetus PHTOEH 89,104,2001
oral
rat
lowest published toxic dose: 11.2 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB92111996
oral
rat
lowest published toxic dose: 77.5 gm/kg (17 week prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB92111996
oral
rat
lowest published toxic dose: 2.3 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) NTIS** #PB92111996
oral
rat
lowest published toxic dose: 66 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB92111996
oral
rat
lowest published toxic dose: 651 mg/kg (multigenerations) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
NTIS** #PB92111996
oral
rat
lowest published toxic dose: 651 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB92111996
oral
rat
lowest published toxic dose: 3,500 mg/kg (12-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 16,10,2002
oral
rat
lowest published toxic dose: 5,000 mg/kg (12-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Urogenital system
REPTED 16,10,2002
oral
rat
lowest published toxic dose: 16.5 gm/kg (7-22 day pregnant/17 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects JJTHEC 65(A),813,2002
oral
rat
lowest published toxic dose: 5,500 mg/kg (7-17 day after birth) Reproductive: Effects on newborn: Behavioral REPTED 17,475,2003
oral
rat
lowest published toxic dose: 4,000 mg/kg (12-19 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) TOSCF2 73,431,2003
oral
rat
lowest published toxic dose: 28 gm/kg (4 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 18,35,2004
oral
rat
lowest published toxic dose: 600 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities
REPTED 18,1,2004
oral
rat
lowest published toxic dose: 23 mg/kg (15-22 day pregnant/15 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system TXCYAC 203,221,2004
oral
rat
lowest published toxic dose: 230 mg/kg (15-22 day pregnant/15 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other postnatal measures or effects
TXCYAC 203,221,2004
oral
rat
lowest published toxic dose: 1,164 mg/kg (75 day prior to copulation/1-22 day pregnant) Reproductive: Other effects on female

Reproductive: Specific developmental abnormalities: Urogenital system
TXCYAC 205,131,2004
oral
rat
lowest published toxic dose: 4,850 mg/kg (75 day prior to copulation/1-22 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TXCYAC 205,131,2004
oral
rat
lowest published toxic dose: 270 mg/kg (12-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 44,281,2005
oral
rat
lowest published toxic dose: 2,500 mg/kg (10-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 78,118,2004
oral
rat
lowest published toxic dose: 4,000 mg/kg (12-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 3,500 mg/kg (13-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 3,000 mg/kg (14-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 2,500 mg/kg (15-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 2,000 mg/kg (16-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 1,500 mg/kg (17-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 1,000 mg/kg (18-19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 500 mg/kg (19 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 78,188,2004
oral
rat
lowest published toxic dose: 3,000 mg/kg (12-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 78,190,2004
oral
rat
lowest published toxic dose: 3,750 mg/kg (14-18 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 78,282,2004
oral
rat
lowest published toxic dose: 4,000 mg/kg (12-19 day pregnant) Reproductive: Other effects on female

Reproductive: Other effects to embryo or fetus
TOXID9 78,282,2004
oral
rat
lowest published toxic dose: 4,000 mg/kg (12-19 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 1,72,2001
oral
rat
lowest published toxic dose: 5,000 mg/kg (12-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
TOXID9 60,216,2001
oral
rat
lowest published toxic dose: 2,500 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TOXID9 90,316,2006
oral
rat
lowest published toxic dose: 3,750 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXCYAC 240,86,2007
oral
rat
lowest published toxic dose: 2,500 mg/kg (14-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXCYAC 232,286,2007
oral
rat
lowest published toxic dose: 2,500 mg/kg (14-18 day pregnant) Reproductive: Effects on newborn: Delayed effects TXCYAC 232,286,2007
oral
rat
lowest published toxic dose: 1,250 mg/kg (14-18 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TXCYAC 232,286,2007
oral
rat
lowest published toxic dose: 5,000 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TXCYAC 232,286,2007
oral
rat
lowest published toxic dose: 3,750 mg/kg (14-18 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) TXCYAC 232,286,2007
oral
rat
lowest published toxic dose: 83 gm/kg (129 day prior to copulation-15 day after birth) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on newborn: Other neonatal measures or effects
TOSCF2 93,189,2006
oral
rat
lowest published toxic dose: 80 gm/kg (61 day male/61 day prior to copulation-15 day after birth) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TOSCF2 93,189,2006
oral
rat
lowest published toxic dose: 53.5 gm/kg (94 day prior to copulation-15 day after birth) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
TOSCF2 93,189,2006
oral
rat
lowest published toxic dose: 60.5 gm/kg (132 day prior to copulation/1-13 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
TOSCF2 93,189,2006
oral
rat
lowest published toxic dose: 121 gm/kg (132 day prior to copulation/1-13 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
TOSCF2 93,189,2006
oral
rat
lowest published toxic dose: 5,000 mg/kg (12-21 day pregnant) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOPADD 31,397,2003
oral
rat
lowest published toxic dose: 5,000 mg/kg (12-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Physical
TOPADD 31,397,2003
oral
rat
lowest published toxic dose: 4,000 mg/kg (12-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOPADD 31,397,2003
oral
rat
lowest published toxic dose: 5,000 mg/kg (12-21 day pregnant) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Specific developmental abnormalities: Urogenital system
TOPADD 32,79,2004
oral
rat
lowest published toxic dose: 5,000 mg/kg (12-21 day pregnant) Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
TOPADD 32,79,2004
oral
rat
lowest published toxic dose: 4,000 mg/kg (12-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TERP1* -,297,2004
oral
rat
lowest published toxic dose: 5,000 mg/kg (12-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TERP1* -,297,2004
oral
rat
lowest published toxic dose: 1,000 mg/kg (15-16 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
BDERB* 74,277,2005
oral
rat
lowest published toxic dose: 1,000 mg/kg (16-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
BDERB* 74,277,2005
oral
rat
lowest published toxic dose: 1,000 mg/kg (16-17 day pregnant) Reproductive: Effects on newborn: Delayed effects BDERB* 74,277,2005
oral
rat
lowest published toxic dose: 1,000 mg/kg (17-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
BDERB* 74,277,2005
oral
rat
lowest published toxic dose: 1,000 mg/kg (17-18 day pregnant) Reproductive: Effects on newborn: Delayed effects BDERB* 74,277,2005
oral
rat
lowest published toxic dose: 1,000 mg/kg (18-19 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
BDERB* 74,277,2005
oral
rat
lowest published toxic dose: 1,000 mg/kg (19-20 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects
BDERB* 74,277,2005
oral
rat
lowest published toxic dose: 1,000 mg/kg (14-15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
BDERB* 74,277,2005
oral
rat
lowest published toxic dose: 900 mg/kg (13-21 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 -,10,2008
oral
rat
lowest published toxic dose: 4,500 mg/kg (13-21 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system
TOXID9 -,10,2008
oral
rabbit
lowest published toxic dose: 5,600 mg/kg (15-29 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects
TOSCF2 72,301,2003
unreported route
rat
lowest published toxic dose: 1,000 mg/kg (16-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 42,176,1998
unreported route
rat
lowest published toxic dose: 1,000 mg/kg (15-16 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 44,113,2005
unreported route
rat
lowest published toxic dose: 1,000 mg/kg (16-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 44,113,2005
unreported route
rat
lowest published toxic dose: 1,000 mg/kg (17-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 44,113,2005
unreported route
rat
lowest published toxic dose: 1,000 mg/kg (18-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 44,113,2005
unreported route
rat
lowest published toxic dose: 1,000 mg/kg (19-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 44,113,2005


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 25 gm/m3/2 hour N/R 85GMAT -,44,1982
inhalation
mouse
lethal concentration (50 percent kill): 25 gm/m3 Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma
ENTOX* -,1,2005
inhalation
rat
lethal concentration (50 percent kill): 4,250 mg/m3 N/R GTPZAB 17(8),26,1973
intramuscular
rat
lethal dose (50 percent kill): >8 gm/kg N/R 14CYAT 2,1904,1963
intraperitoneal
mouse
lethal dose (50 percent kill): 3,570 mg/kg N/R JSCCA5 28,667,1977
intraperitoneal
rat
lethal dose (50 percent kill): 3,050 L/kg N/R JPMSAE 61,51,1972
intraperitoneal
rat
lethal dose (50 percent kill): 4 gm/kg N/R ENTOX* -,1,2005
intravenous
mouse
lethal dose (50 percent kill): 720 mg/kg N/R KEKHB8 (3),19,1973
oral
guinea pig
lethal dose (50 percent kill): 10 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 24(3),25,1980
oral
human
lowest published toxic dose: 140 mg/kg Behavioral: Hallucinations, distorted perceptions

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Other changes
SMWOAS 84,1243,1954
oral
mammal (species unspecified)
lethal dose (50 percent kill): 5 gm/kg N/R GISAAA 39(4),86,1974
oral
mouse
lethal dose (50 percent kill): 3,474 mg/kg N/R WDZAEK 5,264,1991
oral
rat
lethal dose (50 percent kill): 7,499 mg/kg N/R WDZAEK 5,264,1991
oral
rat
lowest published toxic dose: 2,394 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TOLED5 138,215,2003
oral
rat
lowest published toxic dose: 52 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression
TPKVAL 15,123,1979
skin
rat
lowest published lethal dose: 6 gm/kg N/R 85GMAT -,44,1982
skin
rabbit
lethal dose (50 percent kill): >20 mL/kg N/R UCDS** 12/29/1971
unreported route
mouse
lethal dose (50 percent kill): 8,140 mg/kg Behavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
GISAAA 55(6),86,1990
unreported route
rat
lethal dose (50 percent kill): 9,410 mg/kg Behavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
GISAAA 55(6),86,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 900 mg/m3/6 hour/35 day- intermittent Brain and Coverings: Changes in brain weight

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
GTPZAB 17(8),26,1973
intramuscular
mouse
lowest published toxic dose: 151,200 mg/kg/18 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** #PB85144798
intramuscular
mouse
lowest published toxic dose: 151,200 mg/kg/18 week- continuous Liver: Changes in liver weight

Related to Chronic Data: Changes in uterine weight
NTIS** #PB85144798
intramuscular
rat
lowest published toxic dose: 4,557 mg/kg/1 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB92111996
intramuscular
rat
lowest published toxic dose: 77,469 mg/kg/17 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
NTIS** #PB92111996
intramuscular
rat
lowest published toxic dose: 77,469 mg/kg/17 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct
NTIS** #PB92111996
intraperitoneal
rat
lowest published toxic dose: 12 mL/kg/7 day- intermittent Reproductive: Maternal effects: Parturition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
EVHPAZ 3,91,1973
oral
mouse
lowest published toxic dose: 54,600 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
NTPTR* NIH-95-3353
oral
mouse
lowest published toxic dose: 17,000 mg/kg/7 day- intermittent Liver: Changes in liver weight

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 207,149,2005
oral
rat
lowest published toxic dose: 96,750 mg/kg/45 day- intermittent Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 33(6),102,1968
oral
rat
lowest published toxic dose: 42 gm/kg/28 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
NTIS** OTS0530401
oral
rat
lowest published toxic dose: 4 gm/kg/4 day- intermittent Related to Chronic Data: Changes in testicular weight TXAPA9 41,609,1977
oral
rat
lowest published toxic dose: 27,300 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia
NTPTR* NIH-95-3353
oral
rat
lowest published toxic dose: 22,750 mg/kg/1 year- continuous Behavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 26,253,1973
oral
rat
lowest published toxic dose: 11,250 mg/kg/9 day- intermittent Related to Chronic Data: Changes in ovarian weight REPTED 14,13,2000
oral
rat
lowest published toxic dose: 13,500 mg/kg/9 day- intermittent Behavioral: Alteration of classical conditioning

Endocrine: Estrogenic
REPTED 14,13,2000
oral
rat
lowest published toxic dose: 4,500 mg/kg/9 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 14,13,2000
oral
rat
lowest published toxic dose: 6,750 mg/kg/9 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight
REPTED 14,13,2000
oral
rat
lowest published toxic dose: 28,000 mg/kg/10 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
ATSUDG 4,452,1980
oral
rat
lowest published toxic dose: 7,500 mg/kg/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
ARTODN 64,148,1990
oral
rat
lowest published toxic dose: 5 gm/kg/10 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight
JJTHEC 65,813,2002
oral
rat
lowest published toxic dose: 20 gm/kg/10 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JJTHEC 65,813,2002
oral
rat
lowest published toxic dose: 700 mg/kg/14 day- intermittent Endocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
FCTOD7 42,107,2004
oral
rat
lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
FCTOD7 42,107,2004
oral
rat
lowest published toxic dose: 14 gm/kg/14 day- intermittent Liver: Changes in liver weight FCTOD7 42,107,2004
oral
rat
lowest published toxic dose: 8,000 mg/kg/8 day- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
EVHPAZ 111,139,2003
oral
rat
lowest published toxic dose: 3,750 mg/kg/15 day- intermittent Endocrine: Evidence of thyroid hypofunction TOSCF2 69,92,2002
oral
rat
lowest published toxic dose: 7,500 mg/kg/15 day- intermittent Liver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction
TOSCF2 69,92,2002
oral
rat
lowest published toxic dose: 15,000 mg/kg/15 day- intermittent Liver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
TOSCF2 69,92,2002
oral
rat
lowest published toxic dose: 28,000 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
REPTED 18,35,2004
oral
rat
lowest published toxic dose: 1,680 mg/kg/4 week- intermittent Nutritional and Gross Metabolic: Changes in: Metabolic alkalosis REPTED 18,35,2004
oral
rat
lowest published toxic dose: 7,000 mg/kg/4 week- intermittent Liver: Changes in liver weight REPTED 18,35,2004
oral
rat
lowest published toxic dose: 22,500 mg/kg/30 day- intermittent Endocrine: Other changes

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
TOXID9 44,113,2005
oral
rat
lowest published toxic dose: 27,300 mg/kg/13 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 203,41,2004
oral
rat
lowest published toxic dose: 91,000 mg/kg/13 week- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 204,109,2004
oral
rat
lowest published toxic dose: 38,850 mg/kg/12 week- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TXCYAC 205,103,2004
oral
rat
lowest published toxic dose: 4,000 mg/kg/8 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Other
TOXID9 78,282,2004
oral
rat
lowest published toxic dose: 33,012 mg/kg/12 week- intermittent Endocrine: Evidence of thyroid hypofunction

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 213,13,2005
oral
rat
lowest published toxic dose: 22,500 mg/kg/30 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Other
TOXID9 90,219,2006
oral
rat
lowest published toxic dose: 22,500 mg/kg/30 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXCYAC 234,103,2007
oral
rat
lowest published toxic dose: 15,000 mg/kg/30 day- intermittent Related to Chronic Data: Changes in testicular weight TXCYAC 234,103,2007
oral
rat
lowest published toxic dose: 7,500 mg/kg/30 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct TXCYAC 234,103,2007
oral
rat
lowest published toxic dose: 3,750 mg/kg/5 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 232,286,2007
oral
rat
lowest published toxic dose: 96 gm/kg/192 day- intermittent Endocrine: Other changes TOSCF2 93,189,2006
oral
rat
lowest published toxic dose: 121 gm/kg/145 day- intermittent Endocrine: Other changes

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TOSCF2 93,189,2006
oral
rat
lowest published toxic dose: 60.5 gm/kg/145 day- intermittent Endocrine: Changes in pituitary weight TOSCF2 93,189,2006
oral
rat
lowest published toxic dose: 10,000 mg/kg/4 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 17,177,2004
oral
rat
lowest published toxic dose: 2,500 mg/kg/4 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
JTPAE7 17,177,2004
oral
rat
lowest published toxic dose: 625 mg/kg/4 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JTPAE7 17,177,2004
oral
rabbit
lowest published toxic dose: 33,600 mg/kg/12 week- intermittent Endocrine: Androgenic

Endocrine: Changes in thyroid weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
TOSCF2 72,301,2003
subcutaneous
rat
lowest published toxic dose: 3,600 mg/kg/9 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Related to Chronic Data: Changes in testicular weight
JTEHF8 67,2045,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
RREVAH 54,1,1975
TOXICOLOGY REVIEW
EVHPAZ 4,3,1973
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
ESKHA5 (93),1,1975
TOXICOLOGY REVIEW
JACTDZ 4(3),267,1985
TOXICOLOGY REVIEW
FAATDF 13,747,1989
TOXICOLOGY REVIEW
TXAPA9 197,178,2004
TOXICOLOGY REVIEW
REPTED 20,441,2005
TOXICOLOGY REVIEW
BPCEM* 16,105,2002
TOXICOLOGY REVIEW
ENTOX* -,1,2005
TOXICOLOGY REVIEW
ENTOX* -,258,2005
TOXICOLOGY REVIEW
IJTOFN 24,1,2005
TOXICOLOGY REVIEW
CRTXB2 36,695,2006
TOXICOLOGY REVIEW
REPTED 22,291,2006
TOXICOLOGY REVIEW
HUTOX* -,649,1996
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,270,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 DTLVS* 3,75,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 3 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 5 mg/m3, FEB2006
Occupational Exposure Limit - INDIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 mg/m3, sen, APR2007
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 3 mg/m3;
short term exposure limit 5 mg/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3;
short term exposure limit 10 mg/m3, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIBUTYL PHTHALATE-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80248;
Number of Industries 192;
Total Number of Facilities 28,100;
Number of Occupations 114;
Total Number of Employees Exposed 258,823
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80248;
Number of Industries 199;
Total Number of Facilities 31,502;
Number of Occupations 138;
Total Number of Employees Exposed 512,631;
Total Number of Female Employees Exposed 198,249


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/2001/109104/AS)
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as plasticizer, also used in specialized vinyl compounds and nail polish removers
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dibutyl phthalate, 5020
NTP Toxicity studies, RPT# TOX-30, October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000
OSHA ANALYTICAL METHOD #104


REFERENCES:

CODEN
REFERENCE

14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BDERB*
BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi, Osakasayama, Osaka-Fu 589 Japan) V.27- 1987-
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HTOPA*
HUTOX*
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJTHEC Japanese Journal of Toxicology and Environmental Health. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.38- 1992-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
KEKHB8 Kanagawa-ken Eisei Kenkyusho Kenkyu Hokoku. Bulletin of Kanagawa Prefectural Public Health Laboratories. (Kanagawa-ken Eisei Kenkyusho, 52-2, Nakao-cho, Asahi-ku, Yokohama 241, Japan) No.1- 1971-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
OEKSDJ Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Shokuhin Eisei Hen. Research Reports of the Osaka Prefectural Institute of Public Health, Food Sanitation Section. (Osaka-furitsu Koshu Eisei Kenkyusho, 1-3-69 Nakamichi, Higashinari-ku, Osaka 537, Japan) No.1- 1970-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TERP1*
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used as plasticizer, also used in specialized vinyl compounds and nail polish removers

NIOSH PROFILE (PHTHALATES), SRI, 2/77

NIOSH PROFILE (PHTHALATES), SRC, 3/82

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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