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Phosphorus chloride

RTECS #: TH3675000

CAS #: 7719-12-2


UPDATE: May 2009 MW: 137.32 MF: Cl3P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Fosforo (tricloruro di) (Italian)
  2. Fosfortrichloride (Dutch)
  3. Phosphine, trichloro -
  4. Phosphore (trichlorure de) (French)
  5. Phosphorous chloride
  1. Phosphortrichlorid (German)
  2. Phosphorus trichloride
  3. Phosphorus trichloride (ACGIH:OSHA)
  4. Trichlorophosphine
  5. Trojchlorek fosforu (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 40 mg/m3/6 hour Lung, Thorax, or Respiration: Cough

Eye: Conjunctiva irritation
VCVN5* -,71,1993
inhalation
cat
lowest published toxic concentration: 10 mg/m3/1 hour Lung, Thorax, or Respiration: Respiratory depression VCVN5* -,71,1993
inhalation
cat
lowest published lethal concentration: 500 mg/m3 N/R VCVN5* -,71,1993
inhalation
guinea pig
lethal concentration (50 percent kill): 50 ppm/4 hour Eye: Other eye effects

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 25,470,1964
inhalation
guinea pig
lethal concentration (50 percent kill): 63.5 mg/m3 N/R VCVN5* -,71,1993
inhalation
rat
lethal concentration (50 percent kill): 104 ppm/4 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Blood: Hemorrhage
AIHAAP 25,470,1964
inhalation
rat
lethal concentration (50 percent kill): 132 mg/m3 N/R VCVN5* -,71,1993
inhalation
rat
lethal concentration : 0.14 gm/m3 Eye: Lacrimation

Eye: Corneal damage

Behavioral: Somnolence (general depressed activity)
TPKVAL 13,107,1973
inhalation
rat
lethal concentration : 0.31 gm/m3 N/R TPKVAL 13,107,1973
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3 Skin: After systemic exposure: Dermatitis, irritative TPKVAL 13,107,1973
inhalation
rabbit
lowest published lethal concentration: 3,500 mg/m3 N/R VCVN5* -,71,1993
ocular
rabbit
lowest published toxic dose: 100 pph Lung, Thorax, or Respiration: Respiratory stimulation TPKVAL 13,107,1973
oral
mammal (species unspecified)
lethal dose (50 percent kill): 350 mg/kg N/R GISAAA 39(4),86,1974
oral
rat
lethal dose (50 percent kill): 18 mg/kg Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Gastrointestinal: Peritonitis
ATDAEI 1,71,1990
oral
rat
lethal dose (16 percent kill): 430 mg/kg Lung, Thorax, or Respiration: Respiratory depression

Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
TPKVAL 13,107,1973
oral
rat
lethal dose (50 percent kill): 550 mg/kg N/R TPKVAL 13,107,1973
oral
rat
lethal dose : 675 mg/kg N/R TPKVAL 13,107,1973
skin
mouse
lowest published toxic dose: 100 pph/5 minute N/R TPKVAL 13,107,1973
skin
mouse
lowest published toxic dose: 100 pph/1 minute Behavioral: Somnolence (general depressed activity)

Vascular: Other changes
TPKVAL 13,107,1973
skin
rabbit
lowest published lethal dose: 1,260 mg/kg Behavioral: Muscle weakness

Liver: Change in gall bladder structure or function

Blood: Other changes
ATDAEI 1,71,1990
skin
rabbit
lowest published toxic dose: 100 pph Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Ulceration or bleeding from stomach
TPKVAL 13,107,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 ppm;short term exposure limit 0.5 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 ppm (3 mg/m3) DTLVS* 3,211,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 ppm (3 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 ppm (3 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 ppm (3 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 ppm (3 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.5 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.2 ppm (1.1 mg/m3), short term exposure limit 0.5 ppm (2.8 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 ppm(1.1 mg/m3), short term exposure limit 0.5 ppm(2.8 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.2 ppm (1.2 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.5 ppm (3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.2 ppm (1.5 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 2.8 mg/m3 (0.5 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 3 mg/m3, short term exposure limit 3 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.2 ppm (1.1 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.2 ppm (1.5 mg/m3), short term exposure limit 0.5 ppm (3 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.2 ppm (1.1 mg/m3), 2004
Occupational Exposure Limit - MEXICO time-weighted average 0.5 ppm (2.8 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1.5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.2 ppm (1.1 mg/m3), short term exposure limit 0.5 ppm (2.8 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.2 ppm (1.5 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.2 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.2 ppm (1.2 mg/m3);
short term exposure limit 0.4 ppm (2.4 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.25 ppm (1.5 mg/m3),KZG- week 0.25 ppm (1.5 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.5 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 ppm (1.1 mg/m3);
short term exposure limit 0.5 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 ppm;
short term exposure limit 0.5 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 ppm;
short term exposure limit 0.5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORUS TRICHLORIDE-air 10 hour time-weighted average 0.2 ppm;
short term exposure limit 0.5 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 59166;
Number of Industries 4;
Total Number of Facilities 149;
Number of Occupations 12;
Total Number of Employees Exposed 2,520
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 59166;
Number of Industries 4;
Total Number of Facilities 96;
Number of Occupations 6;
Total Number of Employees Exposed 2,963;
Total Number of Female Employees Exposed 329


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate and as a chlorinating agent and catalyst
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phosphorus trichloride, 6402


REFERENCES:

CODEN
REFERENCE

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as an intermediate and as a chlorinating agent and catalyst

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