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Phosphorothioic acid, O,O - dimethyl ester, O,O - diester with 4,4' - thiodiphenol

RTECS #: TF6890000

CAS #: 3383-96-8


UPDATE: May 2009 MW: 466.48 MF: C16H20O6P2S3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. AC 52160
  2. Abaphos
  3. Abate
  4. Abate (OSHA)
  5. Abathion
  6. American cyanamid AC 52,160
  7. American cyanamid CL - 52160
  8. American cyanamid E.I. 52,160
  9. Biothion
  10. CL 52160
  11. Difenthos
  12. Difos
  13. EI 52160
  14. ENT 27,165
  15. Ecopro 1707
  1. Experimental insecticide 52160
  2. Nephis 1G
  3. O,O' - (Thiodi - 4,1 - phenylene) bis (O,O - dimethyl phosphorothioate)
  4. O,O' - (Thiodi - p - phenylene) O,O,O',O' - tetramethyl bis (phosphorothioate)
  5. O,O,O',O' - Tetramethyl O,O' - thiodi - p - phenylene phosphorothioate
  6. O,O - Dimethyl phosphorothioate O,O - diester with 4,4' - thiodiphenol
  7. OMS 786
  8. Phenol, 4,4' - thiodi - , O,O - diester with O,O - dimethyl phosphorothioate
  9. Phosphorothioic acid, O,O' - (thiodi - 4,1 - phenylene) O,O,O',O' - tetramethyl ester
  10. Procida
  11. Swebate
  12. Temefos
  13. Temephos
  14. Temephos (ACGIH:OSHA)
  15. Tetramethyl - O,O' - thiodi - p - phenylene phosphorothioate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg/24 hour mild TXAPA9 21,369,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
lowest published toxic dose: 2,132 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** AD-A134-545


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 683 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Ataxia
TOIZAG 16,297,1969
intraperitoneal
rat
lethal dose (50 percent kill): 912 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands
TOIZAG 16,297,1969
oral
wild bird
lethal dose (50 percent kill): 32 mg/kg N/R TXAPA9 20,57,1971
oral
duck
lethal dose (50 percent kill): 79 mg/kg N/R TXAPA9 20,57,1971
oral
mammal (species unspecified)
lethal dose (50 percent kill): 4,700 mg/kg N/R JAVMA4 152,282,1968
oral
mouse
lethal dose (50 percent kill): 223 mg/kg N/R ARSIM* 20,1,1966
oral
pigeon
lethal dose (50 percent kill): 50 mg/kg N/R TXAPA9 20,57,1971
oral
quail
lethal dose (50 percent kill): 75 mg/kg N/R AECTCV 12,355,1983
oral
rat
lethal dose (50 percent kill): 1 gm/kg N/R GUCHAZ 6,493,1973
oral
rabbit
lethal dose (50 percent kill): 313 mg/kg N/R VETNAL 60(11),63,1984
subcutaneous
chicken
lethal dose : >1 gm/kg Behavioral: Muscle weakness AEHLAU 14,283,1967
subcutaneous
rat
lethal dose (50 percent kill): 2,302 mg/kg Behavioral: Somnolence (general depressed activity) TOIZAG 16,297,1969
skin
rat
lethal dose (50 percent kill): 1,370 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit
lethal dose (50 percent kill): 970 mg/kg N/R AMCYC* 8/1966
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 4 gm/kg N/R 30ZDA9 -,338,1971
unreported route
rat
lethal dose (50 percent kill): 8,600 mg/kg N/R TSPMA6 37(1),45,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
chicken
lowest published toxic dose: 1,668 mg/kg/16 week- continuous Behavioral: Muscle weakness AEHLAU 14,283,1967
oral
dog
lowest published toxic dose: 387 mg/kg/18 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
AEHLAU 14,283,1967
oral
rat
lowest published toxic dose: 14,850 mg/kg/99 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AEHLAU 14,283,1967
oral
rat
lowest published toxic dose: 18,483 mg/kg/44 week- intermittent Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 41(10),101,1976
oral
rabbit
lowest published toxic dose: 18,483 mg/kg/44 week- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 41(10),101,1976


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 mg/m3 (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
RREVAH 46,1,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,152,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 DTLVS* 3,1,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 15 mg/m3, total dust CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3, respirable fraction CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg/m3, Skin, MAR2002
Occupational Exposure Limit - FRANCE VME 10 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 10 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 mg/m3;
short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 mg/m3, JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEMEPHOS, respirable fraction-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TEMEPHOS, total dust-air 10 hour time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AMCYC* Toxicological Information on Cyanamid Insecticides. (American Cyanamid Co., Agricultural Div., Princeton, NJ 08540)
ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-
TSPMA6 Travaux de la Societe de Pharmacie de Montpellier. (Soc. de Pharmacie de Montpellier, Faculte de Pharmacie de Montpellier, Ave. Ch.-Flahault, 34060 Montpellier, France) V.1- 1942-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a mosquito, black fly and midge larvicide

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector
   Primary Irritant

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