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Phosphorothioic acid, O,O - diethyl O - (p - (methylsulfinyl) phenyl) ester

RTECS #: TF3850000

CAS #: 115-90-2


UPDATE: May 2009 MW: 308.37 MF: C11H17O4PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. BAY 25141
  2. Bayer 25141
  3. Chemagro 25141
  4. Daconit
  5. Dasanit
  6. ENT 24,945
  7. Fensulfothion
  8. Fensulfothion (ACGIH)
  9. O,O - Diaethyl - O - (4 - methylsulfinyl - phenyl) - thionophosphat (German)
  1. O,O - Diaethyl - O - 4 - methylsulfinyl - phenyl - monothiophosphat (German)
  2. O,O - Diethyl O - (p - (methylsulfinyl) phenyl) phosphorothioate
  3. O,O - Diethyl O - p - (methylsulfinyl) phenyl thiophosphate
  4. OMS 37
  5. Phenol, p - (methylsulfinyl) - , O - ester with O,O - diethyl phosphorothioate
  6. S 767
  7. Terracur P
  8. VUAgT 108
  9. VUAgT 96


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
mouse
lethal dose (50 percent kill): 2 mg/kg N/R PCBPBS 8,302,1978
inhalation
rat
lethal concentration (50 percent kill): 113 mg/m3/1 hour N/R 85JFAN A202,1983
intraperitoneal
guinea pig
lethal dose (50 percent kill): 5,400 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 6,78,1964
intraperitoneal
mouse
lethal dose (50 percent kill): 7 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 6,78,1964
intraperitoneal
rat
lethal dose (50 percent kill): 1,500 g/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 6,78,1964
oral
wild bird
lethal dose (50 percent kill): 240 g/kg N/R TXAPA9 21,315,1972
oral
duck
lethal dose (50 percent kill): 747 g/kg N/R TXAPA9 22,556,1972
oral
guinea pig
lethal dose (50 percent kill): 9 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 6,78,1964
oral
pigeon
lethal dose (50 percent kill): 560 g/kg N/R ASTTA8 (680),157,1979
oral
quail
lethal dose (50 percent kill): 1,200 g/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
EESADV 8,551,1984
oral
rat
lethal dose (50 percent kill): 2,200 g/kg N/R TXAPA9 6,78,1964
skin
wild bird
lethal dose (50 percent kill): 420 g/kg N/R TXAPA9 26,154,1973
skin
duck
lethal dose (50 percent kill): 3 mg/kg N/R TXAPA9 47,451,1979
skin
rat
lethal dose (50 percent kill): 3 mg/kg N/R WRPCA2 9,119,1970
unreported route
rat
lethal dose (50 percent kill): 11 mg/kg N/R 30ZDA9 -,337,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg/60 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 6,78,1964


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01 mg/m3 (inhalable, vapor, skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,120,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.01 mg/m3, Skin, MAR2002
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg/m3, JAN2002
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO FENSULFOTHION-air 10 hour time-weighted average 0.1 mg/m3 NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
Used to control parasitic, sedentary and free-living nematodes
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used to control parasitic, sedentary and free-living nematodes

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

Click Here for Additional Information about RTECS

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