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Phosphoric acid, 1,2 - dibromo - 2,2 - dichloroethyl dimethyl ester

RTECS #: TB9450000

CAS #: 300-76-5


UPDATE: May 2009 MW: 380.80 MF: C4H7Br2Cl2O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,2 - Dibromo - 2,2 - dichloroethyl dimethyl phosphate
  2. Alvora
  3. Arthodibrom
  4. Bromchlophos
  5. Bromex (insecticide)
  6. Dibrom
  7. Dibromfos
  8. Dimethyl 1,2 - dibromo - 2,2 - dichloroethyl phosphate
  9. Dimethyl - 1,2 - dibromo - 2,2 - dichloroethyl phosphate (OSHA)
  10. ENT 24988
  11. Ethanol, 1,2 - dibromo - 2,2 - dichloro - , dimethyl phosphate
  12. Flibol Ex
  13. Fosforan O - 1,2 - dwubromo - 2,2 - dwuchloroetylo - O,O - dwumetylowy (Polish)
  14. Hibrom
  1. Naled
  2. Naled (ACGIH)
  3. Naledu (Polish)
  4. O,O - Dimethyl O - 2,2 - dichloro - 1,2 - dibromoethyl phosphate
  5. O,O - Dimethyl - O - (1,2 - dibrom - 2,2 - dichlor - aethyl) - phosphat (German)
  6. O,O - Dimethyl - O - (1,2 - dibromo - 2,2 - dichloroethyl) phosphate
  7. O - (1,2 - Dibrom - 2,2 - dichlor - aethyl) - O,O - dimethyl - phosphat (German)
  8. O - (1,2 - Dibromo - 2,2 - dicloro - etil) - O,O - dimetil - fosfato (Italian)
  9. O - (1,2 - Dibroom - 2,2 - dichloor - ethyl) - O,O - dimethyl - fosfaat (Dutch)
  10. OMS 75
  11. Ortho 4355
  12. Phosphate de O,O - dimethyle et de O - (1,2 - dibromo - 2,2 - dichlorethyle) (French)
  13. RE - 4355


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
man
42 mg/21 day- intermittent open irritation test N/R TXAPA9 21,369,1972
skin
rabbit
500 mg/24 hour severe TXAPA9 21,369,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Bacillus subtilis 300 g/plate (+enzymatic activation step) JAFCAU 29,268,1981
mutation in microorganisms Salmonella typhimurium 9,800 g/plate (+enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Salmonella typhimurium 50 g/plate (-enzymatic activation step) JAFCAU 29,268,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration : >1,500 mg/m3/6 hour N/R 85JFAN A289,1983
intraperitoneal
mouse
lethal dose (50 percent kill): 84 mg/kg N/R 85GMAT -,56,1982
intraperitoneal
rat
lethal dose (50 percent kill): 35 mg/kg N/R BECTA6 19,113,1978
oral
duck
lethal dose (50 percent kill): 52 mg/kg N/R DOEAAH 35,25,1979
oral
mammal (species unspecified)
lethal dose (50 percent kill): 430 mg/kg N/R HPBIA9 21,53,1975
oral
mouse
lethal dose (50 percent kill): 222 mg/kg Eye: Other eye effects

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Changes in structure or function of salivary glands
BECTA6 19,113,1978
oral
rat
lethal dose (50 percent kill): 92 mg/kg Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea
ATDAEI 1,90,1990
skin
mouse
lethal dose (50 percent kill): 600 mg/kg N/R JPIFAN (8),24,1971
skin
rat
lethal dose (50 percent kill): 800 mg/kg N/R ENTOX* -,180,2005
skin
rabbit
lethal dose (50 percent kill): 1,100 mg/kg N/R ENTOX* -,180,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,350 mg/kg/9 week- intermittent Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
RPZHAW 20,463,1969


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (inhal, vapor, skin, sen) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
ENTOX* -,180,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,135,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 3 mg/m3 DTLVS* 3,73,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 3 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 3 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 3 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 3 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 3 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 3 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 3 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 3 mg/m3, short term exposure limit 6 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 3 mg/m3, Skin, FEB2006
Occupational Exposure Limit - GERMANY MAK 3 mg/m3 (inhalable), 2005
Occupational Exposure Limit - KOREA time-weighted average 3 mg/m3, skin, 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 3 mg/m3, skin, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 3 mg/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air 10 hour time-weighted average 3 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 26420;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 1;
Total Number of Employees Exposed 16


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HPBIA9 Herba Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.11- 1965-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RPZHAW Roczniki Panstwowego Zakladu Higieny. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in insecticides and acaricides

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data
   Primary Irritant

ALT CAS #: 53095-31-1
Click Here for Additional Information about RTECS

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