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Phosphorane, pentachloro -

RTECS #: TB6125000

CAS #: 10026-13-8


UPDATE: May 2009 MW: 208.22 MF: Cl5P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Fosforo (pentacloruro di) (Italian)
  2. Fosforpentachloride (Dutch)
  3. Phosphore (pentachlorure de) (French)
  4. Phosphoric chloride
  5. Phosphorous pentachloride
  1. Phosphorpentachlorid (German)
  2. Phosphorus pentachloride
  3. Phosphorus pentachloride (ACGIH:OSHA)
  4. Phosphorus perchloride
  5. Pieciochlorek fosforu (Polish)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published lethal concentration: 1,000 mg/m3/10 minute N/R VCVN5* -,72,1993
inhalation
rat
lethal concentration (50 percent kill): 205 mg/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Muscle contraction or spasticity
TNICS* 13,105,1973
inhalation
rat
lethal concentration : 0.12 gm/m3 Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Other
TPKVAL 13,107,1973
inhalation
rat
lethal concentration (50 percent kill): 0.205 gm/m3 Lung, Thorax, or Respiration: Respiratory depression TPKVAL 13,107,1973
inhalation
rat
lethal concentration : 0.34 gm/m3 Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Biochemical: Metabolism (intermediary): Other
TPKVAL 13,107,1973
inhalation
rat
lowest published toxic concentration: 0.8 gm/m3 Skin: After systemic exposure: Dermatitis, irritative TPKVAL 13,107,1973
oral
rat
lethal dose (50 percent kill): 660 mg/kg Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness
TNICS* 13,104,1973
oral
rat
lethal dose (16 percent kill): 550 mg/kg N/R TPKVAL 13,107,1973
oral
rat
lethal dose (50 percent kill): 600 mg/kg N/R TPKVAL 13,107,1973
oral
rat
lethal dose : 650 mg/kg N/R TPKVAL 13,107,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg/m3 DTLVS* 3,211,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.85 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.86 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3, OCT 2002
Occupational Exposure Limit - EC time-weighted average 1 mg/m3, FEB 2006
Occupational Exposure Limit - FINLAND short term exposure limit 1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (1 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 1 mg/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m3, short term exposure limit 1 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (0.85 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (1 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (1 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.85 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg/m3, MAC(short term exposure limit) 0.9 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.2 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 mg/m3;
short term exposure limit 2 mg/m3, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1 mg/m3,KZG- week 1 mg/m3, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 ppm (0.87 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORUS PENTACHLORIDE-air 10 hour time-weighted average 1 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 59160;
Number of Industries 4;
Total Number of Facilities 100;
Number of Occupations 4;
Total Number of Employees Exposed 804
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 59160;
Number of Industries 2;
Total Number of Facilities 21;
Number of Occupations 17;
Total Number of Employees Exposed 2,242;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chlorinating and dehydrating agent and as a catalyst
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TNICS* Toxicology of New Industrial Chemical Substances. English translation of TPKVAL. (USSR Academy of Medical Sciences, Meditsina, Moscow, USSR)
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as a chlorinating and dehydrating agent and as a catalyst

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