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Phosphoramidic acid, methyl - , 4 - tert - butyl - 2 - chlorophenyl methyl ester

RTECS #: TB3850000

CAS #: 299-86-5


UPDATE: May 2009 MW: 291.74 MF: C12H19ClNO3P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. 4 - Tert. butyl 2 - chlorophenyl methylphosphoramidate de methyle (French)
  2. 4 - t - Butyl - 2 - chlorophenyl methyl methylphosphoramidate
  3. Amidofos
  4. Amidophos
  5. Crufomat
  6. Crufomate
  7. Crufomate A
  8. Crufomate (ACGIH)
  9. Dowco 132
  10. ENT 25,602 - X
  11. M - 1261
  12. Methylphosphoramidic acid, 4 - t - butyl - 2 - chlorophenyl methyl ester
  13. Montrel
  1. O - (4 - Tert - butyl - 2 - chlor - phenyl) - O - methyl - phosphorsaeure - N - methylamid (German)
  2. O - (4 - Tert butyl - 2 - chloor - fenyl) - O - methyl - fosforzuur - N - methyl - amide (Dutch)
  3. O - (4 - Terz. - butil - 2 - cloro - fenil) - O - metil - fosforammide (Italian)
  4. O - (4 - tert - Butyl - 2 - chlorophenyl) O - methyl N - methylamido phosphate
  5. O - Methyl O - 2 - chloro - 4 - tert - butylphenyl N - methylamidophosphate
  6. Phenol, 4 - t - butyl - 2 - chloro - , ester with methyl methylphosphoramidate
  7. Phosphoramidic acid, 4 - tert - butyl - 2 - chlorophenylphosphoramidate
  8. Phosphoramidic acid, methyl - , 2 - chloro - 4 - (1,1 - dimethylethyl) phenyl methyl ester
  9. Ruelene
  10. Ruelene drench
  11. Ruelene 25E
  12. Rulene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 100 mg/kg (2 day prior to copulation) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
JPFCD2 13,169,1978
skin
mouse
lowest published toxic dose: 100 mg/kg (2 day prior to copulation) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JPFCD2 16,141,1981
skin
mouse
lowest published toxic dose: 200 mg/kg (2 day prior to copulation) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) JPFCD2 16,141,1981


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 12 mg/m3/4 hour N/R 85GMAT -,29,1982
oral
wild bird
lethal dose (50 percent kill): 100 mg/kg N/R TXAPA9 21,315,1972
oral
dog
lethal dose (50 percent kill): 1 gm/kg N/R VTYMAC 74,1119,1979
oral
guinea pig
lethal dose (50 percent kill): 1 gm/kg Autonomic Nervous System: Other (direct) parasympathomimetic

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Urine volume increased
FCTXAV 6,185,1968
oral
mammal (species unspecified)
lethal dose (50 percent kill): 251 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Muscle contraction or spasticity
VETNAL 54(12),94,1978
oral
rat
lethal dose (50 percent kill): 460 mg/kg N/R TXAPA9 14,515,1969
oral
rabbit
lethal dose (50 percent kill): 400 mg/kg N/R 28ZEAL 5,59,1976
subcutaneous
guinea pig
lowest published lethal dose: 50 mg/kg N/R STCC**
skin
rabbit
lethal dose (50 percent kill): 2 gm/kg N/R SPEADM 78-1,37,1978
unreported route
rat
lethal dose (50 percent kill): 770 mg/kg N/R 30ZDA9 -,317,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
dog
lowest published toxic dose: 36 gm/kg/2 year- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase FCTXAV 6,185,1968
oral
rat
lowest published toxic dose: 44 gm/kg/2 year- continuous Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Changes in testicular weight
FCTXAV 6,185,1968


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, OCT 2002
Occupational Exposure Limit - FRANCE VME 5 mg/m3, FEB2006
Occupational Exposure Limit - KOREA time-weighted average 5 mg/m3, short term exposure limit 20 mg/m3, 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 mg/m3;
short term exposure limit 20 mg/m3, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 mg/m3, JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CRUFOMATE-air 10 hour time-weighted average 5 mg/m3;
short term exposure limit 20 mg/m3
NIOSH* DHHS #95-121,1995


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

N/R


REFERENCES:

CODEN
REFERENCE

28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
SPEADM Special Publication of the Entomological Society of America. (4603 Calvert Rd., College Park, MD 20740)
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VETNAL Veterinariya. Veterinary Science. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1924-
VTYMAC VM/SAC, Veterinary Medicine and Small Animal Clinician. (Veterinary Medicine Publishing Co., 690 S. 4th St., POB 13265, Edwardsville, KS 66113) V.59- 1964-

Used as a topical pesticide for cattle for systemic control of cattle grubs

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

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