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Phosphine

RTECS #: SY7525000

CAS #: 7803-51-2


UPDATE: May 2009 MW: 34.00 MF: H3P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Fosforowodor (Polish)
  2. Gas - Ex - B
  3. Hydrogen phosphide
  4. Phosphine (ACGIH:OSHA)
  1. Phosphorus hydride
  2. Phosphorus trihydride
  3. Phosphorwasserstoff (German)
  4. RCRA waste number P096


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human lymphocyte 1,400 ng/L SCIEAS 246,251,1989
micronucleus test inhalation
mouse
5 ppm/6 hour/13 week- intermittent EMMUEG 24,81,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 70 mg/m3/2 hour N/R VCVN5* -,66,1993
inhalation
guinea pig
lowest published lethal concentration: 139 mg/m3/4 hour N/R VCVN5* -,66,1993
inhalation
human
lowest published lethal concentration: 1,000 ppm/5 minute N/R TABIA2 3,231,1933
inhalation
human
lowest published toxic concentration: 2 mg/m3 Olfaction: Change in sensation of smell VCVN5* -,67,1993
inhalation
human
lowest published lethal concentration: 10 mg/m3 Olfaction: Change in sensation of smell VCVN5* -,67,1993
inhalation
mammal (species unspecified)
lowest published lethal concentration: 1,000 ppm/5 minute N/R AEPPAE 138,65,1928
inhalation
man
lowest published toxic concentration: 2.7 ppm/20 minute Behavioral: Headache

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Hypermotility, diarrhea
CTOXAO 39,165,2001
inhalation
mouse
lowest published lethal concentration: 380 mg/m3/2 hour N/R 85GMAT -,75,1982
inhalation
mouse
lowest published lethal concentration: 380 mg/m3/1 hour N/R VCVN5* -,66,1993
inhalation
mouse
lowest published lethal concentration: 760 mg/m3/35 minute N/R VCVN5* -,66,1993
inhalation
rat
lethal concentration (50 percent kill): 11 ppm/4 hour Lung, Thorax, or Respiration: Dyspnea AIHAAP 36,452,1975
inhalation
rat
lowest published lethal concentration: 140 mg/m3/4 hour N/R VCVN5* -,66,1993
inhalation
rabbit
lowest published lethal concentration: 2,500 ppm/20 minute N/R AEXPBL 27,314,1890
inhalation
rabbit
lowest published lethal concentration: 139 mg/m3/4 hour N/R VCVN5* -,66,1993
inhalation
woman
lowest published toxic concentration: 2.7 ppm/20 minute Behavioral: Headache

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Hypermotility, diarrhea
JTCTDW 39,165,2001
inhalation
woman
lowest published toxic concentration: 242 ppm/30 minute Behavioral: Muscle weakness

Behavioral: Headache
TIHEEC 18,71,2002
intraperitoneal
rat
lowest published toxic dose: 4 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 179,1,2002
intraperitoneal
rat
lowest published toxic dose: 4 mg/kg Cardiac: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOXID9 60,45,2001
intraperitoneal
rat
lowest published toxic dose: 4 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Lipids including transport
TOXID9 60,45,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 14 mg/m3/7 hour/2 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,67,1989
inhalation
mouse
lowest published toxic concentration: 10 ppm/4 hour/4 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
INHTE5 7,225,1995
inhalation
mouse
lowest published toxic concentration: 5 ppm/4 hour/2 week- intermittent Cardiac: Changes in heart weight

Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
INHTE5 7,225,1995
inhalation
mouse
lowest published toxic concentration: 5 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Kidney, Ureter, and Bladder: Changes in bladder weight
JOCHFV 38,36,1996
inhalation
rat
lowest published toxic concentration: 200 g/m3/24 hour/6 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA 49(1),13,1984
inhalation
rat
lowest published toxic concentration: 3,100 ppb/6 hour/13 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count
INHTE5 5,223,1993
inhalation
rat
lowest published toxic concentration: 10 ppm/4 hour/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field INHTE5 7,225,1995
inhalation
rat
lowest published toxic concentration: 5 ppm/4 hour/2 week- intermittent Cardiac: Changes in heart weight

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight
INHTE5 7,225,1995
inhalation
rabbit
lowest published toxic concentration: 14 mg/m3/7 hour/2 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,67,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.3 ppm;short term exposure limit 1 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
NTIS** AD778-725
TOXICOLOGY REVIEW
TIHEEC 18,71,2002
TOXICOLOGY REVIEW
FSINDR 166,190,2007
TOXICOLOGY REVIEW
HUTOX* -,661,1996
TOXICOLOGY REVIEW
HUTOX* -,515,1996
TOXICOLOGY REVIEW
HUTOX* -,561,1996
TOXICOLOGY REVIEW
MUREAV 543,251,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.3 ppm (0.4 mg/m3) DTLVS* 3,209,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.3 ppm (0.4 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.3 ppm (0.4 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.3 ppm (0.4 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.3 ppm (0.4 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.3 ppm (0.42 mg/m3), short term exposure limit 1 ppm (1.4 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.14 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.2 ppm (0.28 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.15 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 0.14 mg/m3 (0.1 ppm);
short term exposure limit 0.28 mg/m3 (0.2 ppm), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.15 mg/m3), short term exposure limit 0.3 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.13 mg/m3), VLE 0.3 ppm (0.4 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.14 mg/m3 (0.1 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.14 mg/m3, short term exposure limit 0.14 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit- continuous 0.3 ppm (0.42 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.3 ppm (0.4 mg/m3), short term exposure limit 1 ppm (1 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.3 ppm (0.4 mg/m3);
short term exposure limit 1 ppm (1 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.4 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.3 ppm (0.42 mg/m3), short term exposure limit 1 ppm (1.4 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.15 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.8 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.3 ppm (0.4 mg/m3);
short term exposure limit 1 ppm (1.4 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.15 mg/m3),KZG- week 0.1 ppm (0.15 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.3 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.3 ppm (0.42 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.3 ppm;
short term exposure limit 1 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.3 ppm;
short term exposure limit 1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHINE-air 10 hour time-weighted average 0.3 ppm;
short term exposure limit 1.0 ppm
NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a fumigant, a doping agent for electronic components, and in chemical synthesis
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Phosphine, 6002
OSHA ANALYTICAL METHOD #ID180


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FSINDR Forensic Science International. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.12- 1978-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTOX*
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JOCHFV Journal of Occupational Health. (Japan Society for Occupational Health, 1-29-8 Shinjuku, Shinjuku-ku, Tokyo, 160, Japan) V.38- 1996-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63. Discontinued.
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as a fumigant, a doping agent for electronic components, and in chemical synthesis

NIOSH PROFILE (PETROCHEMICAL PLANTS), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

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