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Phosgene

RTECS #: SY5600000

CAS #: 75-44-5


UPDATE: May 2009 MW: 98.91 MF: CCl2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. CG
  2. Carbon dichloride oxide
  3. Carbon oxychloride
  4. Carbone (oxychlorure de) (French)
  5. Carbonic chloride
  6. Carbonio (ossicloruro di) (Italian)
  7. Carbonylchlorid (German)
  8. Carbonyl chloride (DOT:OSHA)
  9. Carbonyl dichloride
  1. Chloroformyl chloride
  2. Fosgeen (Dutch)
  3. Fosgen (Polish)
  4. Fosgene (Italian)
  5. Koolstofoxychloride (Dutch)
  6. NCI - C60219
  7. Phosgen (German)
  8. Phosgene (ACGIH:OSHA)
  9. RCRA waste number P095


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published lethal concentration: 190 mg/m3/15 minute N/R 85GMAT -,99,1982
inhalation
human
lowest published lethal concentration: 50 ppm/5 minute N/R TABIA2 3,231,1933
inhalation
human
lowest published toxic concentration: 25 ppm/30 minute Lung, Thorax, or Respiration: Other changes 29ZWAE -,207,1968
inhalation
mammal (species unspecified)
lowest published lethal concentration: 50 ppm/5 minute N/R AEPPAE 138,65,1928
inhalation
mammal (species unspecified)
lowest published lethal concentration: 11 mg/m3/30 minute N/R TABIA2 3,231,1933
inhalation
man
lowest published lethal concentration: 360 mg/m3/30 minute N/R 85GMAT -,99,1982
inhalation
mouse
lowest published toxic concentration: 32 mg/m3/20 minute Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,145,2004
inhalation
mouse
lowest published toxic concentration: 32 mg/m3/20 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Changes in lung weight
TOXID9 66,144,2002
inhalation
mouse
lowest published toxic concentration: 32 mg/m3/20 minute Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
TOXID9 66,193,2002
inhalation
mouse
lowest published lethal concentration: 0.65 gm/m3/30 minute Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TPKVAL 5,123,1963
inhalation
mouse
lethal concentration (50 percent kill): 0.5 gm/m3/2 hour N/R TPKVAL 9,7,1967
inhalation
mouse
lethal concentration (50 percent kill): 12.35 ppm/2 hour N/R TPKVAL 9,7,1967
inhalation
mouse
lowest published toxic concentration: 37 mg/m3/20 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Blood: Other changes
INHTE5 15,663,2003
inhalation
pig
lowest published lethal concentration: 2,443 mg/m3/10 minute Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Changes in lung weight
JJATDK 22,263,2002
inhalation
pig
lowest published lethal concentration: 24,430 mg/m3/10 minute Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
JAPTO* 22,263,2002
inhalation
pig
lowest published toxic concentration: 24,430 mg/m3/10 minute Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Other changes
JAPTO* 22,263,2002
inhalation
pig
lowest published toxic concentration: 24,430 mg/m3/10 minute Vascular: Structural changes in vessels JAPTO* 22,263,2002
inhalation
rat
lowest published toxic concentration: 0.6 ppm/10 minute Lung, Thorax, or Respiration: Acute pulmonary edema TOXID9 72,160,2003
inhalation
rat
lowest published toxic concentration: 0.3 ppm/1 hour Lung, Thorax, or Respiration: Acute pulmonary edema TOXID9 72,160,2003
inhalation
rat
lowest published toxic concentration: 0.8 ppm/4 hour Lung, Thorax, or Respiration: Acute pulmonary edema TOXID9 72,160,2003
inhalation
rat
lowest published toxic concentration: 0.4 ppm/8 hour Lung, Thorax, or Respiration: Acute pulmonary edema TOXID9 72,160,2003
inhalation
rat
lowest published toxic dose: 32 mg/m3/20 minute Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
INHTE5 15,687,2003
inhalation
rat
lowest published toxic concentration: 0.25 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TIHEEC 17,285,2001
inhalation
rat
lowest published toxic concentration: 0.2 ppm/6 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TIHEEC 17,285,2001
inhalation
rat
lowest published lethal concentration: 0.65 gm/m3/30 minute Cardiac: Other changes

Liver: Fatty liver degeneration

Liver: Other changes
TPKVAL 5,123,1963
inhalation
rat
lowest published toxic concentration: 32 mg/m3/20 minute Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
INHTE5 15,687,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 200 ppb/6 hour/4 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in lung weight
FAATDF 37,54,1997
inhalation
rat
lowest published toxic concentration: 250 ppb/4 hour/17 day- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
JTEHD6 19,413,1986
inhalation
rat
lowest published toxic concentration: 500 ppb/6 hour/12 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 37,54,1997
inhalation
rat
lowest published toxic concentration: 1.0 ppm/6 hour/4 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TIHEEC 17,285,2001
inhalation
rat
lowest published toxic concentration: 0.5 ppm/12 hour/12 week- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial) TIHEEC 17,285,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ANAEA3 35,165,1975
TOXICOLOGY REVIEW
AEHLAU 28,272,1974
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
CPEMM* 3,239,2002
TOXICOLOGY REVIEW
DIMON* 46,551,2000
TOXICOLOGY REVIEW
HUTOX* -,661,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.4 mg/m3) DTLVS* 3,208,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.4 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.4 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.4 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.4 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.02 ppm (0.08 mg/m3), short term exposure limit 0.06 ppm (0.25 mg/m3),JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.02 ppm (0.08 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.1 ppm (0.4 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.02 ppm (0.08 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 0.08 mg/m3 (0.02 ppm);
short term exposure limit 0.4 mg/m3 (0.1 ppm), FEB 2006
Occupational Exposure Limit - FINLAND short term exposure limit 0.05 ppm (0.2 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 0.02 ppm (0.08 mg/m3), VLE 0.1 ppm (0.4 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.082 mg/m3 (0.02 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.08 mg/m3, short term exposure limit 0.4 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (0.4 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.4 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (0.4 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.08 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.02 ppm (0.08 mg/m3), short term exposure limit 0.06 ppm (0.25 mg/m3), JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.1 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.5 mg/m3, MAC(short term exposure limit) 1.5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN ceiling concentration 0.05 ppm (0.2 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.02 ppm (0.08 mg/m3);
KZG- week 0.04 ppm (0.16 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.4 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.02 ppm (0.08 mg/m3);
short term exposure limit 0.06 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSGENE-air 10 hour time-weighted average 0.1 ppm;
ceiling concentration 0.2 ppm/15 minute
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 57710;
Number of Industries 10;
Total Number of Facilities 408;
Number of Occupations 11;
Total Number of Employees Exposed 5,729
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 57710;
Number of Industries 5;
Total Number of Facilities 57;
Number of Occupations 10;
Total Number of Employees Exposed 2,358;
Total Number of Female Employees Exposed 282


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate in the manufacture of many industrial chemicals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID-61


REFERENCES:

CODEN
REFERENCE

29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CPEMM* Clinical Pediatric Emergency Medicine (Philadelphia, PA : W.B. Saunders Co.)
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
HUTOX*
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TABIA2 Tabulae Biologicae. (The Hague, Netherlands) V.1-22, 1925-63. Discontinued.
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as an intermediate in the manufacture of many industrial chemicals

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

NIOSH PROFILE (SMELTERS, SECONDARY NON-FERROUS), SRI, 2/77

RTECS Compound Description:
   Human Data

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