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Osmium tetroxide

RTECS #: RN1140000

CAS #: 20816-12-0


UPDATE: May 2009 MW: 254.20 MF: O4Os


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Osmic acid
  2. Osmium tetroxide (ACGIH:OSHA)
  1. Osmium (VIII) oxide
  2. RCRA waste number P087


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA repair Bacillus subtilis 5 mmol/L MUREAV 77,109,1980
unscheduled DNA synthesis hamster embryo 200 mol/L MUREAV 131,173,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratesticular
rat
lowest published toxic dose: 20,336 g/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964
subcutaneous
mouse
lowest published toxic dose: 20,336 g/kg (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
man
lowest published toxic concentration: 133 g/m3 Eye: Lacrimation

Eye: Other eye effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi
BJIMAG 3,183,1946
inhalation
mouse
lowest published lethal concentration: 40 ppm/4 hour N/R SCCUR* -,8,1961
inhalation
rat
lowest published lethal concentration: 40 ppm/4 hour N/R SCCUR* -,8,1961
inhalation
rabbit
lowest published lethal concentration: 1,316 mg/m3/30 minute Behavioral: Coma

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes
JIDHAN 15,136,1933
intraperitoneal
mouse
lethal dose (50 percent kill): 13,500 g/kg N/R SCCUR* -,8,1961
intraperitoneal
rat
lethal dose (50 percent kill): 14,100 g/kg N/R SCCUR* -,8,1961
ocular
rabbit
lowest published toxic dose: 0.25 mg/kg Eye: Corneal damage VCVN5* -,526,1989
oral
mouse
lethal dose (50 percent kill): 162 mg/kg N/R SCCUR* -,8,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.0002 ppm;short term exposure limit 0.0006 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ISMEA* 9,750,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.002 mg/m3 DTLVS* 3,192,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.002 mg(Os)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.002 mg(Os)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.002 mg(Os)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.002 mg(Os)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.0002 ppm (0.002 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.0002 ppm (0.0016 mg/m3), short term exposure limit 0.0006 ppm (0.0047mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.0002 ppm (0.0016 mg(Os)/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.0006 ppm (0.0048 mg(Os)/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.0002 ppm (0.002 mg(Os)/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.0002 mg/m3, short term exposure limit 0.002 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.0002 ppm (0.002 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.0021 mg(Os)/m3 (0.0002 mL(Os)/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 0.002 mg(Os)/m3, short term exposure limit 0.002 mg(Os)/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.0002 ppm (0.0002 mg/m3), short term exposure limit 0.0006 ppm (0.0006 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.0002 ppm;
short term exposure limit 0.0006 ppm, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.002 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.0002 ppm (0.0016 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.0002 ppm (0.002 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.002 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.0002 ppm (0.002 mg(Os)/m3),KZG- week 0.002 mg(Os)/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.0002 ppm;
short term exposure limit 0.0006 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.0002 ppm;
short term exposure limit 0.0006 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.0002 ppm;
short term exposure limit 0.0006 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OSMIUM TETROXIDE-air 10 hour time-weighted average 0.0002 ppm;
short term exposure limit 0.0006 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 52370;
Number of Industries 2;
Total Number of Facilities 195;
Number of Occupations 2;
Total Number of Employees Exposed 370
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 52370;
Number of Industries 2;
Total Number of Facilities 87;
Number of Occupations 5;
Total Number of Employees Exposed 1,733;
Total Number of Female Employees Exposed 420


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as catalyst, fixative and oxidizing agent
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE

BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ISMEA*
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as catalyst, fixative and oxidizing agent

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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