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Nitric acid

RTECS #: QU5775000

CAS #: 7697-37-2


UPDATE: May 2009 MW: 63.02 MF: HNO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acide nitrique (French)
  2. Acido nitrico (Italian)
  3. Aqua fortis
  4. Azotic acid
  5. Azotowy kwas (Polish)
  1. Hydrogen nitrate
  2. Kyselina dusicne (Czech)
  3. Nitric acid (ACGIH:OSHA)
  4. Salpetersaure (German)
  5. Salpeterzuuroplossingen (Dutch)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 21,150 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ZHYGAM 29,667,1983
oral
rat
lowest published toxic dose: 2,345 mg/kg (18 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic ZHYGAM 29,667,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 300 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,45,1993
inhalation
cat
lowest published lethal concentration: 500 mg/m3 N/R VCVN5* -,45,1993
inhalation
rat
lethal concentration (50 percent kill): 260 mg/m3/30 minute N/R VCVN5* -,45,1993
inhalation
rat
lethal concentration (50 percent kill): 130 mg/m3/4 hour N/R VCVN5* -,45,1993
inhalation
rat
lowest published toxic concentration: 460 ppm/1 hour Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 44,302,2005
inhalation
rat
lowest published lethal concentration: 919 ppm/1 hour N/R TOXID9 44,302,2005
oral
human
lowest published lethal dose: 430 mg/kg N/R YAKUD5 22,651,1980
skin
rat
lowest published toxic dose: 150 mL/kg Blood: Methemoglobinemia- Carboxhemoglobinemia VCVN5* -,46,1993
unreported route
man
lowest published lethal dose: 110 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,071 g/m3/24 hour/84 day- continuous Behavioral: Muscle contraction or spasticity

Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 38(3),6,1973
inhalation
rat
lowest published toxic concentration: 50 g/m3/4 hour/3 day- intermittent Lung, Thorax, or Respiration: Respiratory depression INHTE5 8,595,1996


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm;short term exposure limit 4 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ANAEA3 35,165,1975
TOXICOLOGY REVIEW
ARTODN 39,299,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 ppm (5 mg/m3) DTLVS* 3,181,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 2 ppm (5 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 2 ppm (5 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 2 ppm (5 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 2 ppm (5 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 2 ppm (5 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (5.2 mg/m3), short term exposure limit 4 ppm (10 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM short term exposure limit 1 ppm (2.6 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (5 mg/m3), OCT 2002
Occupational Exposure Limit - EC short term exposure limit 2.6 mg/m3 (1 ppm), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 2 ppm (5 mg/m3), short term exposure limit 5 ppm (13 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2 ppm (5 mg/m3), VLE 4 ppm (10 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 5.2 mg/m3 (2 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg/m3, short term exposure limit 5 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 2 ppm (5.2 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 2 ppm (5 mg/m3), short term exposure limit 4 ppm (10 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 2 ppm (5 mg/m3);
short term exposure limit 4 ppm (10 mg/m3), 2004
Occupational Exposure Limit - NEW ZEALAND time-weighted average 2 ppm (5.2 mg/m3), short term exposure limit 4 ppm (10 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 2 ppm (5 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 2 ppm (5 mg/m3);
short term exposure limit 5 ppm (13 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (5 mg/m3),KZG- week 2 ppm (5 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 2 ppm (5 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 2 ppm (5 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 ppm (5.2 mg/m3);
short term exposure limit 4 ppm (10 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 ppm;
short term exposure limit 4 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 ppm;
short term exposure limit 4 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITRIC ACID-air 10 hour time-weighted average 2 ppm;
short term exposure limit 4 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50742;
Number of Industries 197;
Total Number of Facilities 18,088;
Number of Occupations 101;
Total Number of Employees Exposed 132,401
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50742;
Number of Industries 201;
Total Number of Facilities 18,239;
Number of Occupations 120;
Total Number of Employees Exposed 297,627;
Total Number of Female Employees Exposed 76,316


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in chemicals, explosives, fertilizers, steel pickling, metal cleaning
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acids, inorganic, 7903
OSHA ANALYTICAL METHOD #ID-127


REFERENCES:

CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955-

Used in chemicals, explosives, fertilizers, steel pickling, metal cleaning

Top 50 chemical production: 16.08 billions lbs in 1992, 15.85 billions in 1991

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data

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