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Nickel carbonyl

RTECS #: QR6300000

CAS #: 13463-39-3


UPDATE: May 2009 MW: 170.75 MF: C4NiO4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Nichel tetracarbonile (Italian)
  2. Nickel carbonyl (ACGIH:OSHA)
  3. Nickel carbonyle (French)
  4. Nickel tetracarbonyle (French)
  1. Nickel tetracarbonyl
  2. Nikkeltetracarbonyl (Dutch)
  3. RCRA waste number P073
  4. Tetracarbonyl nickel


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
hamster
lowest published toxic concentration: 60 mg/m3/15 minute (5 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Other developmental abnormalities
NTIS** DOE/EV/03140-5
inhalation
hamster
lowest published toxic concentration: 60 mg/m3/15 minute (5 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) NTIS** DOE/EV/03140-5
inhalation
hamster
lowest published toxic concentration: 60 mg/m3/15 minute (4 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Respiratory system
48ECAY 3,301,1980
inhalation
rat
lowest published toxic concentration: 60 mg/m3/15 minute (8 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TXAPA9 45,345,1978
inhalation
rat
lowest published toxic concentration: 120 mg/m3/15 minute (8 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 45,345,1978
inhalation
rat
lowest published toxic concentration: 160 mg/m3/15 minute (7 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) SCIEAS 203,550,1979
intravenous
rat
lowest published toxic dose: 25 mg/kg (7 day pregnant) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
50WKA3 -,399,1983
intravenous
rat
lowest published toxic dose: 25 mg/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death 50WKA3 -,399,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 250 mg/m3/30 minute/1 year Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AJCPAI 35,203,1961
inhalation
rat
toxic concentration (other than lowest) : 4 ppm/30 minute/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
AJPAA4 46,1027,1965
intravenous
rat
lowest published toxic dose: 54 mg/kg/20 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
CNREA8 32,2253,1972


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lethal concentration (50 percent kill): 1,890 mg/m3/30 minute N/R EQSSDX 1,1,1975
inhalation
cat
lethal concentration (50 percent kill): 1,900 mg/m3/30 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Liver function tests impaired

Liver: Changes in liver weight
VCVN5* -,501,1989
inhalation
dog
lowest published lethal concentration: 360 ppm/90 minute N/R JOHYAY 7,525,1907
inhalation
human
lowest published toxic concentration: 7 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature increase
GISAAA 22(11),30,1957
inhalation
human
lowest published lethal concentration: 30 ppm/30 minute N/R AEHLAU 23,373,1971
inhalation
human
lowest published lethal concentration: 0.3 pph/1 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Respiratory obstruction

Kidney, Ureter, and Bladder: Renal function tests depressed
VCVN5* -,503,1989
inhalation
mouse
lethal concentration (50 percent kill): 67 mg/m3/30 minute Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Other changes
AMIHBC 8,48,1953
inhalation
mouse
lethal concentration (50 percent kill): 67 mg/m3/30 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Liver function tests impaired

Liver: Changes in liver weight
VCVN5* -,501,1989
inhalation
mouse
lethal concentration : 0.4 gm/m3/2 hour Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Other changes in urine composition
TPKVAL 10,144,1968
inhalation
mouse
lethal concentration (50 percent kill): 0.1 gm/m3/2 hour N/R TPKVAL 9,7,1967
inhalation
mouse
lethal concentration (50 percent kill): 1.4 ppm/2 hour N/R TPKVAL 9,7,1967
inhalation
rat
lethal concentration (50 percent kill): 35 ppm/30 minute N/R AJCPAI 26,107,1956
inhalation
rat
lethal concentration (50 percent kill): 873 mg/m3/30 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Liver function tests impaired

Liver: Changes in liver weight
VCVN5* -,501,1989
inhalation
rat
lethal concentration (50 percent kill): 151 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Liver function tests impaired

Liver: Changes in liver weight
VCVN5* -,501,1989
inhalation
rat
lethal concentration (50 percent kill): 81.5 mg/m3/4 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Liver function tests impaired

Liver: Changes in liver weight
VCVN5* -,501,1989
inhalation
rabbit
lowest published lethal concentration: 300 mg/m3/30 minute N/R YAKUD5 22,455,1980
intraperitoneal
rat
lethal dose (50 percent kill): 39 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AEHLAU 14,604,1967
intravenous
rat
lethal dose (50 percent kill): 64 mg/kg Biochemical: Metabolism (intermediary): Other RCOCB8 2,545,1971
subcutaneous
rat
lethal dose (50 percent kill): 63 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
AEHLAU 14,604,1967
skin
rabbit
lowest published toxic dose: 0.1 mL/kg Behavioral: Somnolence (general depressed activity)

Vascular: Regional or general arteriolar or venous dilation

Lung, Thorax, or Respiration: Respiratory stimulation
TPKVAL 10,144,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 2,500 g/m3/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL (10),144,1968
inhalation
rat
lowest published toxic concentration: 30 mg/m3/30 minute/52 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
AMIHAB 16,480,1957
inhalation
rat
lowest published toxic concentration: 5.8 mg/m3/4 hour/3 week- intermittent Lung, Thorax, or Respiration: Respiratory depression

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,504,1989
inhalation
rat
lowest published toxic concentration: 0.5 gm/m3/14 day- intermittent Skin and Appendages: Other: Breast

Reproductive: Tumorigenic effects: Ovarian tumors

Reproductive: Tumorigenic effects: Uterine tumors
TPKVAL 10,144,1968


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm(Ni) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMSUDL 7,264,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 49,257,1990
TOXICOLOGY REVIEW
ACLSCP 3,156,1973
TOXICOLOGY REVIEW
ANAEA3 35,165,1975
TOXICOLOGY REVIEW
FEPRA7 35,89,1976
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
85DHAX Ni,168,1975
TOXICOLOGY REVIEW
PEXTAR 12,102,1969
TOXICOLOGY REVIEW
DICHAK 54,527,1968
TOXICOLOGY REVIEW
CTOXAO 12,601,1978
TOXICOLOGY REVIEW
CREOH* 42,35,2002
TOXICOLOGY REVIEW
ENTOX* -,220,2005
TOXICOLOGY REVIEW
MUREAV 533,92,2003
TOXICOLOGY REVIEW
HBTME* ,743,2007
TOXICOLOGY REVIEW
HBTME* ,743,2007
TOXICOLOGY REVIEW
HUTOX* -,515,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.001 ppm (0.007 mg/m3) DTLWS* 3,24,1973
Mine Safety and Health Administration (MSHA) STANDARD HUMAN CARCINOGEN DTLWS* 3,24,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.001 ppm (0.007 mg(Ni)/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.001 ppm (0.007 mg(Ni)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.001 ppm (0.007 mg(Ni)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.001 ppm (0.007 mg(Ni)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.007 ppm (0.001 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 ppm (0.12 mg/m3), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Ni)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.12 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.001 ppm (0.007 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.001 ppm (0.007 mg/m3), short term exposure limit 0.003 ppm, Carcinogen,JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 ppm (0.12 mg/m3), continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 0.15 mg/m3, short term exposure limit 0.15 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.001 ppm (0.007 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 0.001 ppm (0.007 mg(Ni)/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.05 ppm (0.35 mg(Ni)/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.35 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.05 ppm (0.12 mg(Ni)/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.001 ppm (0.007 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.001 ppm (0.007 mg/m3), JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.003 mg/m3, MAR2004
Occupational Exposure Limit - SWEDEN time-weighted average 0.001 ppm (0.007 mg/m3), Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.35 mg/m3), Skin, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.001 ppm (0.007 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.001 ppm (0.007 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.1 ppm (0.24 mg(Ni)/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NICKEL CARBONYL-air Carcinogen;
10 hour time-weighted average 0.001 ppm
NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate product in the refining of NICKEL
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nickel carbonyl, 6007
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE

48ECAY "Spurenelement-Symposium: Nickel, 3rd," Jena, Anke, M., et al., eds., Jena, Ger. Dem. Rep., Friedrich-Schiller-Universitaet, 1980
50WKA3 "Reproduction and Developmental Toxicity of Metals, Proceedings of a Joint Meeting, Rochester, 1982," Clarkson, T.W., et al., eds., New York, Plenum Pub. Corp., 1983
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl., Philadelphia, PA 19103) V.1- 1971-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AJCPAI American Journal of Clinical Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1931-
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671, Bloomington, MN 55420) V.1- 1943-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CREOH* Critical Reviews in Oncology/Hematology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1983-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DICHAK Diseases of the Chest. (Chicago, IL) V.1-56, 1935-69. For publisher information, see CHETBF.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTME*
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1901-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1- 1960-
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as an intermediate product in the refining of NICKEL

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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