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2 - Naphthylamine, N - phenyl -

RTECS #: QM4550000

CAS #: 135-88-6


UPDATE: May 2009 MW: 219.30 MF: C16H13N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Anilinonaphthalene
  2. 2 - Naphthylphenylamine
  3. 2 - Phenylaminonaphthalene
  4. AK 1
  5. AK 1 (stabilizer)
  6. Aceto PBN
  7. AgeRite Powder
  8. Antioxidant PBN
  9. Antioxidant 116
  10. Antioxidant D
  11. Fenyl - beta - naftylamin (Czech)
  12. N - (2 - Naphthyl) aniline
  13. N - Fenyl - 2 - aminonaftalen (Czech)
  14. N - Phenyl - beta - naphthylamine
  15. N - Phenyl - 2 - naphthylamine
  16. N - Phenyl - beta - naphthylamine (ACGIH)
  1. NCI - C02915
  2. Naftam 2
  3. Neozon D
  4. Neozone
  5. Neozone D
  6. Nilox PbNa
  7. Noclizer D
  8. Nocrac D
  9. Nonox D
  10. PBNA
  11. Phenyl - beta - naphthylamine
  12. Phenyl - 2 - naphthylamine
  13. Stabilizator AR
  14. Stabilizer AR
  15. Vulkanox PBN
  16. beta - Naphthylphenylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
mouse
360 mg/kg/18 day GTPZAB 23(9),57,1979
mutation in microorganisms Salmonella typhimurium 50 pph (+enzymatic activation step) CYGEDX 21(6),29,1987
morphological transform human other cell types 23,100 µg/L ITCSAF 17,719,1981
specific locus test inhalation
mouse
59.3 µmol/L MUREAV 608,29,2006


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 18,200 mg/kg (26 week male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
TPKVAL 12,86,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 433 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-333,1988
oral
mouse
lowest published toxic dose: 208 gm/kg/97 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
SYSWAE 14,129,1981
oral
mouse
toxic dose : 264 gm/kg/99 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
SYSWAE 14,129,1981
oral
mouse
toxic dose : 135 gm/kg/78 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTIS** PB223-159
oral
mouse
toxic dose : 17,280 mg/kg/9 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
CNREA8 44,3098,1984
oral
mouse
lowest published toxic dose: 648,900 mg/kg/103 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB88-216270/AS
subcutaneous
mouse
lowest published toxic dose: 464 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published lethal concentration: 0.9 gm/m3/2 hour Brain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes

Behavioral: Coma
TPKVAL 6,37,1964
oral
mouse
lethal dose (50 percent kill): 1,450 mg/kg Behavioral: Somnolence (general depressed activity) HYSAAV 31(1-3),183,1966
oral
rat
lethal dose (50 percent kill): 8,730 mg/kg Behavioral: Somnolence (general depressed activity) HYSAAV 31(1-3),183,1966
oral
rat
lowest published toxic dose: 8,000 mg/kg N/R TPKVAL 12,86,1971
subcutaneous
mouse
lowest published toxic dose: 1,000 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: General anesthetic
TPKVAL 6,37,1964
subcutaneous
rat
lowest published toxic dose: 1,000 mg/kg Lung, Thorax, or Respiration: Respiratory obstruction

Liver: Fatty liver degeneration

Biochemical: Metabolism (intermediary): Other
TPKVAL 6,37,1964
unreported route
rat
lethal dose (50 percent kill): 8,700 mg/kg Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes
TJSGA8 53,415,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 100 gm/m3/6 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL 10,90,1968
inhalation
guinea pig
lowest published toxic concentration: 100 gm/m3/12 day- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 6,37,1964
inhalation
rat
lowest published toxic concentration: 0.9 gm/m3/10 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in spleen
TPKVAL 6,37,1964
oral
guinea pig
lowest published toxic dose: 6,000 mg/kg/40 day- intermittent Vascular: Other changes

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 6,37,1964
oral
mouse
lowest published toxic dose: 437 gm/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-333,1988
oral
rat
lowest published toxic dose: 52 gm/kg/30 day- intermittent Liver: Liver function tests impaired

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GISAAA 31(2),25,1966
oral
rat
lowest published toxic dose: 182 gm/kg/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-333,1988
oral
rat
lowest published toxic dose: 19 gm/kg/19 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TPKVAL 12,86,1971
oral
rat
lowest published toxic dose: 36,400 mg/kg/1 year- intermittent Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Urine volume increased

Kidney, Ureter, and Bladder: Proteinuria
TPKVAL 12,86,1971
oral
rat
lowest published toxic dose: 4,000 mg/kg/4 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TPKVAL 12,86,1971
oral
rat
lowest published toxic dose: 3,650 mg/kg/0.5 year- continuous Gastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition
TPKVAL 12,86,1971
oral
rat
lowest published toxic dose: 54,700 mg/kg/1.5 year- continuous Kidney, Ureter, and Bladder: Urine volume decreased or anuria TPKVAL 12,86,1971
oral
rat
lowest published toxic dose: 3,000 mg/kg/30 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Proteinuria
TPKVAL 12,86,1971
oral
rat
lowest published toxic dose: 36,500 mg/kg/1 year- continuous Lung, Thorax, or Respiration: Changes in lung weight TPKVAL 12,86,1971
oral
rat
lowest published toxic dose: 18,200 mg/kg/0.5 year- continuous Gastrointestinal: Necrotic changes

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 12,86,1971
oral
rabbit
lowest published toxic dose: 5,000 mg/kg/5 day- intermittent Kidney, Ureter, and Bladder: Proteinuria

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 6,37,1964
oral
rabbit
lowest published toxic dose: 12,000 mg/kg/3 day- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TPKVAL 6,37,1964
subcutaneous
rat
lowest published toxic dose: 30,000 mg/kg/60 week- intermittent Skin and Appendages: Tumors

Tumorigenic: Protects against induction of experimental tumors
VOONC* 37,60,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 16,325,1978
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 16,325,1978
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,318,1987
TOXICOLOGY REVIEW
TOLED5 134,39,2002
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA Carcinogen, JUL2008
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.03 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN Group B Carcinogen, JUN2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO N-PHENYL-beta-NAPHTHYLAMINE-air Carcinogen lowest concentration NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80313;
Number of Industries 15;
Total Number of Facilities 751;
Number of Occupations 32;
Total Number of Employees Exposed 16,148
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80313;
Number of Industries 2;
Total Number of Facilities 33;
Number of Occupations 4;
Total Number of Employees Exposed 1,356;
Total Number of Female Employees Exposed 41


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antioxidant and as a stabilizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 16, 1976
NCI Carcinogenesis Studies (feed);equivocal evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat
OSHA ANALYTICAL METHOD #96


REFERENCES:

CODEN
REFERENCE

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CYGEDX Cytology and Genetics (English Translation). Translation of TGANAK. (Allerton Press Inc., 150 Fifth Ave., New York, NY 10011) V.8- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher information, see ICDBEO.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SYSWAE Shiyan Shengwu Xuebao. Journal of Experimental Biology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1953- Suspended 1966-77.
TJSGA8 Tijdschrift Voor Sociale Geneeskunde. (B.V. Uitgeversmaatschappij. Reflex, Mathenesserlaan 310, Rotterdam 3003, Netherlands) V.1- 1923-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VOONC* Voprosi oncologii (Questions of oncology. Journal of Petrov's Institute of Oncology, B. Zelenina str, 43a, Spb 197110, Russia) V.1- 1955-

Used as an antioxidant and as a stabilizer

NIOSH PROFILE (AMINES, SECONDARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

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