CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Methylamine

RTECS #: PF6300000

CAS #: 74-89-5


UPDATE: May 2009 MW: 31.07 MF: CH5N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Aminomethane
  2. Carbinamine
  3. Mercurialin
  4. Methanamine (9CI)
  5. Methylaminen (Dutch)
  1. Methylamine (ACGIH:OSHA)
  2. Metilamine (Italian)
  3. Metyloamina (Polish)
  4. Monomethylamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
40% severe ENTOX* 86,-,2005
eye
rabbit
5% mild ENTOX* 86,-,2005
skin
guinea pig
100 mg open irritation test severe CODEDG 6,140,1980
skin
rabbit
40% severe ENTOX* 86,-,2005


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
dominant lethal test inhalation
rat
10 g/m3 GISAAA 46(5),7,1981
mutation in mammalian somatic cells mouse lymphocyte 3 mmol/L MUREAV 174,285,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
mouse
lowest published toxic dose: 88.8 ng/kg Brain and Coverings: Other degenerative changes

Behavioral: Food intake (animal)
BJPCBM 142,381,2004
intracerebral
rat
lowest published toxic dose: 78.95 g/kg Brain and Coverings: Other degenerative changes

Behavioral: Food intake (animal)
BJPCBM 150,1003,2007
intracerebral
rat
lowest published toxic dose: 315.79 g/kg Behavioral: Food intake (animal)

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
BJPCBM 150,1003,2007
inhalation
cat
lowest published toxic concentration: 0.4 gm/m3 N/R TPKVAL 7,56,1965
inhalation
human
lowest published toxic concentration: 0.1 gm/m3 Behavioral: Alteration of classical conditioning TPKVAL 7,56,1965
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 2,400 mg/m3 N/R TPKVAL 14,80,1975
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 3.7 gm/m3 Eye: Conjunctiva irritation TPKVAL 7,56,1965
inhalation
mouse
lethal concentration (50 percent kill): 2,400 mg/m3/2 hour N/R ENTOX* -,86,2005
inhalation
rat
lethal concentration (50 percent kill): 448 ppm/2.5 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Skin: After systemic exposure: Dermatitis, irritative
JEBIDP 13,273,1992
inhalation
rat
lethal concentration (50 percent kill): 448 ppm/2.5 hour N/R ENTOX* -,86,2005
oral
rat
lethal dose (50 percent kill): 100 mg/kg N/R ENTOX* -,86,2005
subcutaneous
guinea pig
lowest published lethal dose: 200 mg/kg N/R HBAMAK 4,1289,1935
subcutaneous
mouse
lowest published lethal dose: 2,500 mg/kg N/R 85KYAH 11,949,1989
subcutaneous
rat
lowest published lethal dose: 200 mg/kg N/R HBAMAK 4,1289,1935
unreported route
mouse
lethal dose (50 percent kill): 317 mg/kg N/R HBPTO* 1,825,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 750 ppm/6 hour/2 week- intermittent Olfaction: Other olfaction effects

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in testicular weight
INHTE5 2,29,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm;short term exposure limit 15 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CHREAY 9,389,1931
TOXICOLOGY REVIEW
ENTOX* -,86,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 ppm (12 mg/m3) DTLVS* 3,156,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 ppm (12 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 ppm (12 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 ppm (12 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 ppm (12 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (13 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (6.6 mg/m3), short term exposure limit 15 ppm (19 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (6.4 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 10 ppm (12 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 13 mg/m3 (10 mL/m3), 2005
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 10 ppm (13 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (12 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 10 ppm (12 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 6.4 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (13 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 ppm (12 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 15 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (13 mg/m3);
short term exposure limit 20 ppm (25 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 10 ppm (12 mg/m3),KZG- week 10 ppm (12 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm;
short term exposure limit 15 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm;
short term exposure limit 15 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLAMINE-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 46470;
Number of Industries 5;
Total Number of Facilities 175;
Number of Occupations 9;
Total Number of Employees Exposed 1,098
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 46470;
Number of Industries 6;
Total Number of Facilities 197;
Number of Occupations 24;
Total Number of Employees Exposed 10,890;
Total Number of Female Employees Exposed 1,411


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in organic synthesis
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #40


REFERENCES:

CODEN
REFERENCE

85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JEBIDP Journal of Environmental Biology. (Academy of Environmental Biology, India, 657/5, Civil Lines (South), Muzaffarnagar, 251001, India) V.1- 1980-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used in organic synthesis

NIOSH PROFILE (AMINES, PRIMARY ALIPHATIC), SRI, 2/77

NIOSH PROFILE (AMINES, SECONDARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Natural Product
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us