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4,7 - Methanoindene, 1,4,5,6,7,8,8 - heptachloro - 3a,4,7,7a - tetrahydro -

RTECS #: PC0700000

CAS #: 76-44-8


UPDATE: May 2009 MW: 373.30 MF: C10H5Cl7


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1 (3a) ,4,5,6,7,8,8 - Heptachloro - 3a (1) ,4,7,7a - tetrahydro - 4,7 - methanoindene
  2. 1,4,5,6,7,10,10 - Heptachloro - 4,7,8,9 - tetrahydro - 4,7 - endomethyleneindene
  3. 1,4,5,6,7,10,10 - Heptachloro - 4,7,8,9 - tetrahydro - 4,7 - methyleneindene
  4. 1,4,5,6,7,8,8 - Eptacloro - 3a,4,7,7a - tetraidro - 4,7 - endo - metano - indene (Italian)
  5. 1,4,5,6,7,8,8 - Heptachloor - 3a,4,7,7a - tetrahydro - 4,7 - endo - methano - indeen (Dutch)
  6. 1,4,5,6,7,8,8 - Heptachlor - 3a,4,7,7,7a - tetrahydro - 4,7 - endo - methano - inden (German)
  7. 1,4,5,6,7,8,8 - Heptachloro - 3a,4,7,7,7a - tetrahydro - 4,7 - methylene indene
  8. 1,4,5,6,7,8,8 - Heptachloro - 3a,4,7,7a - tetrahydro - 4,7 - endomethanoindene
  9. 1,4,5,6,7,8,8 - Heptachloro - 3a,4,7,7a - tetrahydro - 4,7 - methanoindene
  10. 1,4,5,6,7,8,8 - Heptachloro - 3a,4,7,7a - tetrahydro - 4,7 - methanol - 1H - indene
  11. 1,4,5,6,7,8,8a - Heptachloro - 3a,4,7,7a - tetrahydro - 4,7 - methanoindane
  12. 3,4,5,6,7,8,8 - Heptachlorodicyclopentadiene
  13. 3,4,5,6,7,8,8a - Heptachlorodicyclopentadiene
  14. 3 - Chlorochlordene
  15. Aahepta
  16. Agroceres
  17. Analytical grade heptachlor
  18. Arbinex 30TN
  19. Dicyclopentadiene, 3,4,5,6,7,8,8a - heptachloro -
  20. Drinox
  21. E 3314
  22. ENT 15,152
  23. Eptacloro (Italian)
  1. GPKh
  2. H
  3. H - 34
  4. H - 60
  5. Hepta
  6. Heptachloor (Dutch)
  7. Heptachlor
  8. Heptachlor (ACGIH:OSHA)
  9. Heptachlor (technical grade)
  10. Heptachlorane
  11. Heptachlore (French)
  12. Heptagran
  13. Heptamul
  14. Heptox
  15. Latka 104 (Czech)
  16. NCI - C00180
  17. OMS 193
  18. RCRA waste number P059
  19. Rhodiachlor
  20. Velsicol 104
  21. Velsicol heptachlor
  22. Velsicol104


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster fibroblast 67.0 mol/L MUREAV 608,28,2006
cytogenetic analysis hamster 67.0 mol/L MUREAV 608,28,2006
cytogenetic analysis intraperitoneal
mouse
5,200 g/kg SOGEBZ 2,80,1966
cytogenetic analysis oral
rat
60 g/kg 34LXAP -,555,1976
dominant lethal test oral
rat
60 g/kg 34LXAP -,555,1976
unscheduled DNA synthesis human fibroblast 100 mol/L MUREAV 42,161,1977
mutation in mammalian somatic cells mouse lymphocyte 25 mg/L EMMUEG 12,85,1988
morphological transform hamster embryo 10 mg/L AETODY 1,241,1980
other mutation test systems Escherichia coli 837 mol/L EMMUEG 19,98,1992
other mutation test systems oral
mouse
35 mg/kg MUREAV 343,157,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 57 mg/kg (2 week prior to copulation-21 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 78,378,2004
oral
mouse
lowest published toxic dose: 57 mg/kg (14 day prior to copulation-21 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic NETOX* 26,721,2005
oral
rat
lowest published toxic dose: 350 mg/kg (14 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
PHTOEH 76,112,1995
oral
rat
lowest published toxic dose: 3,168 mg/kg (70 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Other effects on male

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
PHTOEH 76,112,1995
oral
rat
lowest published toxic dose: 0.51 mg/kg (multigenerations) Reproductive: Other developmental abnormalities TOSCF2 60,315,2001
oral
rat
lowest published toxic dose: 51 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Central nervous system TOSCF2 60,315,2001
oral
rat
lowest published toxic dose: 30 mg/kg (12-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOSCF2 61,164,2001
oral
rat
lowest published toxic dose: 510 g/kg (multigenerations) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TOSCF2 61,164,2001
oral
rat
lowest published toxic dose: 51 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system TOSCF2 61,164,2001
oral
rat
lowest published toxic dose: 510 g/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities
TOSCF2 61,164,2001
oral
rat
lowest published toxic dose: 45 mg/kg (10 day pregnant-2 day after birth) Reproductive: Other developmental abnormalities TOXID9 66,131,2002
oral
rat
lowest published toxic dose: 99 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Central nervous system TOXID9 66,131,2002
oral
rat
lowest published toxic dose: 50.4 mg/kg (10-21 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 78,378,2004
oral
rat
lowest published toxic dose: 25.2 mg/kg (14 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Other measures of fertility
TOXID9 -,238,2008
subcutaneous
rat
lowest published toxic dose: 140 mg/kg (14 day prior to copulation) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) CBPCBB 110C,221,1995
unreported route
rat
lowest published toxic dose: 48 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TOXID9 72,171,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 403 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-9,1977
oral
mouse
toxic dose : 930 mg/kg/80 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NCITR* NCI-TR-9,1977
oral
mouse
toxic dose : 876 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
ECEBDI 45,147,1977


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
mouse
lethal dose (50 percent kill): 12 mg/kg Behavioral: Convulsions or effect on seizure threshold TOLED5 60,289,1992
inhalation
cat
lowest published lethal concentration: 150 mg/m3/4 hour N/R 85GMAT -,71,1982
inhalation
mammal (species unspecified)
lowest published lethal concentration: 200 mg/m3/4 hour Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Behavioral: Aggression
GTPZAB 2(5),15,1958
intraperitoneal
mouse
lethal dose (50 percent kill): 130 mg/kg N/R SOGEBZ 2,80,1966
intraperitoneal
rat
lethal dose (50 percent kill): 27 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
FCTXAV 11,63,1973
intraperitoneal
rat
lowest published toxic dose: 93.3 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Metabolism (intermediary): Other
GEPHDP 18,165,1987
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Biochemical: Metabolism (intermediary): Other
TOXID9 60,245,2001
intravenous
mouse
lowest published lethal dose: 20 mg/kg N/R JPETAB 107,266,1953
oral
cat
lowest published lethal dose: 50 mg/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Behavioral: Aggression
GTPZAB 2(5),15,1958
oral
cat
lethal dose (50 percent kill): 50 mg/kg N/R VCVGH* -,561,1990
oral
guinea pig
lethal dose (50 percent kill): 116 mg/kg N/R PCOC** -,576,1966
oral
hamster
lethal dose (50 percent kill): 100 mg/kg N/R EJTXAZ 7,159,1974
oral
mouse
lethal dose (50 percent kill): 30 mg/kg N/R ENTOX* -,502,2005
oral
rat
lethal dose (50 percent kill): 40 mg/kg N/R PHJOAV 185,361,1960
oral
rat
lowest published toxic dose: 60 mg/kg Brain and Coverings: Other degenerative changes TOXID9 72,304,2003
skin
guinea pig
lowest published lethal dose: 1 gm/kg Behavioral: Excitement

Behavioral: Muscle contraction or spasticity

Behavioral: Aggression
GTPZAB 2(5),15,1958
skin
rat
lethal dose (50 percent kill): 119 mg/kg N/R SPEADM 78-1,12,1978
skin
rabbit
lethal dose (50 percent kill): 500 mg/kg N/R VCVGH* -,561,1990
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 60 mg/kg N/R 30ZDA9 -,59,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1.6 mg/m3/4 hour/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGH* -,561,1990
intraperitoneal
mouse
lowest published toxic dose: 9 mg/kg/2 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
NRTXDN 20,631,1999
intraperitoneal
mouse
lowest published toxic dose: 150 mg/kg/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOSCF2 61,100,2001
intraperitoneal
mouse
lowest published toxic dose: 18 mg/kg/2 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
NRTXDN 23,537,2002
intraperitoneal
mouse
lowest published toxic dose: 75 mg/kg/3 day- intermittent Brain and Coverings: Other degenerative changes TOSCF2 61,100,2001
intraperitoneal
mouse
lowest published toxic dose: 6 mg/kg/3 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum TOSCF2 61,100,2001
intraperitoneal
mouse
lowest published toxic dose: 18 mg/kg/2 week- intermittent Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum NRTXDN 23,537,2002
intraperitoneal
rat
lowest published toxic dose: 70 mg/kg/7 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other
TXAPA9 19,234,1971
oral
mammal (species unspecified)
lowest published toxic dose: 2,800 mg/kg/28 day- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in adrenal weight

Endocrine: Changes in spleen weight
AECTCV 19,913,1990
oral
rat
lowest published toxic dose: 22,750 mg/kg/26 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Lipids including transport
GISAAA 30(3),13,1965
oral
rabbit
lowest published toxic dose: 0.63 mg/kg/3 week- continuous Immunological Including Allergic: Decreased immune response HBPTO* 1,771,2001
subcutaneous
rat
lowest published toxic dose: 45 mg/kg/18 day- intermittent Endocrine: Estrogenic

Endocrine: Other changes
CBPCEE 111C,191,1995
subcutaneous
rat
lowest published toxic dose: 225 mg/kg/18 day- intermittent Endocrine: Effect on menstrual cycle CBPCEE 111C,191,1995
subcutaneous
rat
lowest published toxic dose: 180 mg/kg/18 day- intermittent Endocrine: Effect on menstrual cycle

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CBCPAI 110C,221,1995
subcutaneous
rat
lowest published toxic dose: 140 mg/kg/14 day- intermittent Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
CBCPAI 110C,221,1995
skin
rabbit
lowest published toxic dose: 475 mg/kg/19 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 2(5)15,1958


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 20,129,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMSUDL 7,146,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 53,115,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 5,173,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 20,129,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 53,115,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 53,115,1991
TOXICOLOGY REVIEW
TOLED5 127,101,2002
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
BNYMAM 54,413,1978
TOXICOLOGY REVIEW
CTOXAO 13,231,1978
TOXICOLOGY REVIEW
85CVA2 5,250,1970
TOXICOLOGY REVIEW
MUTAEX 21,93,2006
TOXICOLOGY REVIEW
NETOX* 26,531,2005
TOXICOLOGY REVIEW
ENTOX* -,502,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
JTEHD6 7,1,2004
TOXICOLOGY REVIEW
REPTED 23,457,2007
TOXICOLOGY REVIEW
ITODC* -,327,2004
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,123,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg/m3 (skin) DTLVS* 3,123,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3, Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg/m3, OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg/m3, short term exposure limit 1.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.03 ppm (0.5 mg/m3), continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - GERMANY MAK 0.5 mg/m3 (inhalable), 2005
Occupational Exposure Limit - HUNGARY Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.5 mg/m3, skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.5 mg/m3;
short term exposure limit 2 mg/m3 (skin), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.5 mg/m3, skin, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.01 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg/m3,KZG- week 1 mg/m3, Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 1 mg/m3, Skin, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO HEPTACHLOR-air Carcinogen;
10 hour time-weighted average 0.5 mg/m3 (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 35960;
Number of Industries 2;
Total Number of Facilities 346;
Number of Occupations 8;
Total Number of Employees Exposed 907
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 35960;
Number of Industries 2;
Total Number of Facilities 120;
Number of Occupations 2;
Total Number of Employees Exposed 1,034


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182467/AS)
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
Used as an insecticide for control of cotton boll weevil
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse NCITR* NCI-TR-9,1977
NCI Carcinogenesis Bioassay (feed);no evidence:rat NCITR* NCI-TR-9,1977


REFERENCES:

CODEN
REFERENCE

30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
34LXAP "Insecticide Biochemistry and Physiology," Wilkinson, C.F., ed., New York, Plenum Pub. Corp., 1976
85CVA2 "Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book Medical Pub., 1971
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AETODY Advances in Modern Environmental Toxicology. (Senate Press, Inc., P.O. Box 252, Princeton Junction, NJ 08550) V.1- 1980-
BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925-
CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8.
CBPCBB Comparative Biochemistry and Physiology, C: Comparative Pharmacology. (Elsevier Science, POB 800, Kidlington, Oxford OX5 1DX, UK) V.50-73, 1975-82. For publisher information, see CBPCEE.
CBPCEE Comparative Biochemistry and Physiology, C: Pharmacology, Toxicology and Endocrinology. (Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.74- 1983-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ECEBDI Experimental Cell Biology. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.44- 1976-
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HTOPA*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
ITODC*
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NETOX* NeuroToxicology (Amsterdam : Elsevier Science) V.1- 1979-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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Used as an insecticide for control of cotton boll weevil

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 23720-59-4
ALT CAS #: 37229-06-4
Click Here for Additional Information about RTECS

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