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4,7 - Methanoindene, 3a,4,7,7a - tetrahydro -

RTECS #: PC1050000

CAS #: 77-73-6


UPDATE: May 2009 MW: 132.22 MF: C10H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3 - Cyclopentadiene, dimer
  2. 3a,4,7,7a - Tetrahydro - 4,7 - methanoindene
  3. Bicyclopentadiene
  4. Biscyclopentadiene
  1. Dicyclopentadiene
  2. Dicyclopentadiene (ACGIH)
  3. Dicyklopentadien (Czech)
  4. Dimer cyklopentadienu (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
9,300 g/24 hour open irritation test severe AIHAAP 23,95,1962
skin
rabbit
20 mg/24 hour moderate 85JCAE -,50,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 22,400 mg/kg (multigeneration) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TOXID9 15,166,1995


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published lethal concentration: 773 ppm/1 hour N/R TXAPA9 20,552,1971
inhalation
guinea pig
lethal concentration (50 percent kill): 770 ppm/4 hour N/R TXAPA9 20,552,1971
inhalation
guinea pig
lethal concentration (50 percent kill): 2,100 mg/m3 N/R VCVGH* -,106,1990
inhalation
human
lowest published toxic concentration: 16 mg/m3 Behavioral: Headache VCVGH* -,106,1990
inhalation
mouse
lethal concentration (50 percent kill): 145 ppm/4 hour N/R TXAPA9 20,552,1971
inhalation
mouse
lethal concentration (50 percent kill): 400 mg/m3/2 hour N/R VCVGH* -,106,1990
inhalation
rat
lethal concentration (50 percent kill): 660 ppm/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay)
NTIS** OTS0557739
inhalation
rat
lethal concentration (50 percent kill): 610 mg/m3/4 hour N/R VCVGH* -,106,1990
inhalation
rabbit
lethal concentration (50 percent kill): 771 ppm/4 hour N/R TXAPA9 20,552,1971
inhalation
rabbit
lethal concentration (50 percent kill): 4,200 mg/m3 N/R VCVGH* -,106,1990
intraperitoneal
mammal (species unspecified)
lethal dose (50 percent kill): 960 mg/kg N/R NTIS** AD-A087-257
intraperitoneal
mouse
lethal dose (50 percent kill): 200 mg/kg N/R NCIUS* PH43-64-886
intraperitoneal
rat
lethal dose (50 percent kill): 200 mg/kg N/R NCIUS* PH43-64-886
oral
domestic bird
lethal dose (50 percent kill): 1,010 mg/kg N/R NTIS** AD-A087-257
oral
cattle
lethal dose (50 percent kill): 1,200 mg/kg Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** AD-A093-673
oral
mouse
lethal dose (50 percent kill): 190 mg/kg N/R VCVGH* -,106,1990
oral
rat
lethal dose (50 percent kill): 353 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
TXAPA9 20,552,1971
oral
rat
lethal dose (50 percent kill): 520 mg/kg Behavioral: Convulsions or effect on seizure threshold VCVGH* -,106,1990
oral
rat
lethal dose (50 percent kill): 370 mg/kg N/R VCVGH* -,106,1990
skin
rabbit
lethal dose (50 percent kill): 5,080 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
TXAPA9 20,552,1971
skin
rabbit
lethal dose (50 percent kill): 5.08 mL/kg N/R VCVGH* -,107,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 72 ppm/7 hour/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 20,552,1971
inhalation
mouse
lowest published toxic concentration: 714 ppm/6 hour/11 day- continuous Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0536197
inhalation
rat
lowest published toxic concentration: 250 ppm/6 hour/2 week- intermittent Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BJIMAG 27,1,1970
inhalation
rat
lowest published toxic concentration: 35 ppm/7 hour/18 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
TXAPA9 20,552,1971
inhalation
rat
lowest published toxic concentration: 5 ppm/6 hour/13 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Nutritional and Gross Metabolic: Changes in: Na

Nutritional and Gross Metabolic: Changes in: P
TIHEEC 8,353,1992
inhalation
rat
lowest published toxic concentration: 20 mg/m3/4 hour/26 week- intermittent Behavioral: Excitement

Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Proteinuria
GTPZAB 9(12),13,1965
oral
rat
lowest published toxic dose: 182 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
GISAAA 51(2),77,1986
oral
rat
lowest published toxic dose: 1,120 mg/kg/28 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ESKHA5 (108),71,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (27 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (27 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2.7 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (30 mg/m3), short term exposure limit 10 ppm (54 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 5 ppm (30 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 2.7 mg/m3 (0.5 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 5 ppm (30 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 5 ppm (30 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 5 ppm (27 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (3 mg/m3),KZG- week 0.5 ppm (3 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (27 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOPENTADIENE-air 10 hour time-weighted average 5 ppm NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83439;
Number of Industries 24;
Total Number of Facilities 2,292;
Number of Occupations 38;
Total Number of Employees Exposed 41,365
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83439;
Number of Industries 4;
Total Number of Facilities 252;
Number of Occupations 8;
Total Number of Employees Exposed 6,248;
Total Number of Female Employees Exposed 442


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of pesticides, elastomers, resin systems and polymers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ESKHA5 Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the National Cancer Institute by The Institute of Chemical Biology, University of San Francisco. (San Francisco, CA 94117)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in production of pesticides, elastomers, resin systems and polymers

NIOSH PROFILE (ALKENES), SRI, 2/77

NIOSH PROFILE (CYCLOPENTADIENES), SRC, 12/79

NIOSH PROFILE (ALKENES), SRC, 4/78

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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