Methane, triiodo-

RTECS #

PB7000000

CAS #

75-47-8
See: NMAM or OSHA Methods

Updated

June 2017

Molecular Weight

393.72

Molecular Formula

CHI₃

Synonyms

Carbon triiodide
Dezinfekt V
Iodoform
Iodoform (ACGIH)
Jodoform (Czech)
NCI-C04568
Triiodomethane
Trijodmethane (Czech)

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
Cytogenetic Analysis	other cell types/human	100 µmol/L/3H	MUREAV 649,45,2008
morphological transform	embryo/hamster	10 mg/L	SHIGAZ 74,1385,1987
mutation in microorganisms	/Salmonella typhimurium	67 µg/plate (+enzymatic activation step)	ENMUDM 5(Suppl 1),3,1983
sister chromatid exchange	embryo/hamster	1 mg/L	SHIGAZ 74,1385,1987
Unscheduled DNA Synthesis	embryo/hamster	1 mg/L	SHIGAZ 74,1385,1987

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/rat	lethal concentration (50 percent kill): 165 ppm/7H	Lung, Thorax, or Respiration: Respiratory stimulation	JTEHD6 8,59,1981
inhalation/rat	lethal concentration (50 percent kill): 183 ppm/7H		VCVGH* -,605,1990
oral/Dog	lowest published lethal dose: 10 gm/kg	Behavioral: Tremor Behavioral: Muscle contraction or spasticity Lung, Thorax, or Respiration: Dyspnea	ZEPTAT 1,446,1905
oral/guinea pig	lethal dose (50 percent kill): 487 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea	ZDTUAB 27(5),9,1983
oral/mammal (species unspecified)	lowest published lethal dose: 1 gm/kg		HBAMAK 4,1289,1935
oral/mouse	lethal dose (50 percent kill): 470 mg/kg		GISAAA 52(11),74,1987
oral/rabbit	lethal dose (50 percent kill): 450 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea	ZDTUAB 27(5),9,1983
oral/rat	lethal dose (50 percent kill): 355 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea	ZDTUAB 27(5),9,1983
skin/rat	lethal dose (50 percent kill): 1184 mg/kg	Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea	ZDTUAB 27(5),9,1983
subcutaneous/mammal (species unspecified)	lowest published lethal dose: 1500 mg/kg		HBAMAK 4,1289,1935
subcutaneous/mouse	lethal dose (50 percent kill): 630 mg/kg	Behavioral: Antipsychotic Vascular: Other changes Lung, Thorax, or Respiration: Other changes	TXAPA9 4,354,1962
subcutaneous/rabbit	lowest published lethal dose: 500 mg/kg		ZEPTAT 1,446,1905
unreported route/frog	lowest published lethal dose: 606 mg/kg		ZEPTAT 1,446,1905

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
oral/rat	lowest published toxic dose: 875 mg/kg/35D- intermittent	Liver: Changes in liver weight Blood: Changes in erythrocyte (RBC) count Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects	GISAAA 52(11),74,1987
oral/rat	lowest published toxic dose: 2166 mg/kg/61D- intermittent	Liver: Other changes	ZDTUAB 27(5),9,1983

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 0.6 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		MUREAV 584,1,2005
TOXICOLOGY REVIEW		MUREAV 636,242,2007
TOXICOLOGY REVIEW		MUREAV 705,184,2010
TOXICOLOGY REVIEW		MUREAV 802,1,2016

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 0.6 ppm (10 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 0.2 ppm (3 mg/m³);KZW 0.4 ppm (6 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 0.6 ppm (10 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 0.2 ppm (3 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 0.2 ppm (3.3 mg/m³), short term exposure limit 0.6 ppm (9.8 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 0.6 ppm (10 mg/m³), FEB2006
Occupational Exposure Limit-ICELAND	time-weighted average 0.2 ppm (3 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 0.6 ppm (10 mg/m³), 2006
Occupational Exposure Limit-MEXICO	time-weighted average 0.6 ppm (10 mg/m³);short term exposure limit 1 ppm (20 mg/m³), 2004
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 0.6 ppm (10 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 0.2 ppm (3 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 0,6 ppm (9,7 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 3 mg/m³, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 0.6 ppm (10 mg/m³), sen, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 3 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 0.8 ppm (9.8 mg/m³);short term exposure limit 1 ppm (16 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IODOFORM-air	10H time-weighted average 0.6 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 84474; Number of Industries 4; Total Number of Facilities 510; Number of Occupations 12; Total Number of Employees Exposed 22584; Total Number of Female Employees Exposed 20381
National Occupational Hazard Survey 1974	Hazard Code 84474; Number of Industries 2; Total Number of Facilities 390; Number of Occupations 5; Total Number of Employees Exposed 1882

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NCI Carcinogenesis Bioassay (gavage);no evidence:mouse,rat	NCITR* NCI-TR-110,1978

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health