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Methanamine, N,N - dimethyl -

RTECS #: PA0350000

CAS #: 75-50-3


UPDATE: May 2009 MW: 59.13 MF: C3H9N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Dimethylmethaneamine
  2. N,N - Dimethylmethanamine
  1. Trimethylamine
  2. Trimethylamine (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 4,430 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Physical
CJPPA3 71,185,1993
intraperitoneal
mouse
lowest published toxic dose: 2,960 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) CJPPA3 71,185,1993


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 19 gm/m3 N/R TPKVAL 14,80,1975
inhalation
mouse
lethal concentration (50 percent kill): 19 gm/m3 Behavioral: Somnolence (general depressed activity)

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity
GTPZAB 11(4),26,1967
inhalation
rat
lowest published lethal concentration: 3,500 ppm/4 hour N/R TOXID9 4,68,1984
intraperitoneal
mouse
lethal dose (50 percent kill): 946 mg/kg N/R YKKZAJ 97,1117,1977
intravenous
mouse
lethal dose (50 percent kill): 90 mg/kg N/R MPHEAE 16,529,1967
intravenous
rabbit
lowest published lethal dose: 160 mg/kg N/R CRSBAW 83,481,1920
oral
pig
lowest published lethal dose: 1 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Food intake (animal)
INHTE5 2,41,1990
oral
rat
lethal dose (50 percent kill): 500 mg/kg N/R INHTE5 2,41,1990
rectal
rabbit
lowest published lethal dose: 800 mg/kg N/R CRSBAW 83,481,1920
subcutaneous
frog
lowest published lethal dose: 2 gm/kg Cardiac: Pulse rate decreased with fall in BP

Cardiac: Other changes

Blood: Other changes
SAPHAO 10,201,1900
subcutaneous
rabbit
lowest published lethal dose: 800 mg/kg N/R CRSBAW 83,481,1920
unreported route
guinea pig
lethal dose (50 percent kill): 315 mg/kg N/R GISAAA 46(8),79,1981
unreported route
mouse
lethal dose (50 percent kill): 460 mg/kg N/R GISAAA 46(8),79,1981
unreported route
rat
lethal dose (50 percent kill): 535 mg/kg N/R GISAAA 46(8),79,1981
unreported route
rabbit
lethal dose (50 percent kill): 240 mg/kg N/R GISAAA 46(8),79,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 75 mg/m3/5 hour/30 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Endocrine: Changes in adrenal weight

Blood: Changes in other cell count (unspecified)
GTPZAB 11(4),26,1967
inhalation
rat
lowest published toxic concentration: 750 ppm/6 hour/2 week- intermittent Olfaction: Other olfaction effects

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
INHTE5 2,41,1990
unreported route
rabbit
lowest published toxic dose: 437 mg/kg/26 week- intermittent Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Monoamine oxidase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 46(8),79,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm;short term exposure limit 15 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CHREAY 9,389,1931


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (24 mg/m3), short term exposure limit 15 ppm (36 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (12 mg/m3), short term exposure limit 15 ppm (37 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (12 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VLE 10 ppm (25 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 4.9 mg/m3 (2 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 12.3 mg/m3, short term exposure limit 36.9 mg/m3, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 10 ppm (24 mg/m3), short term exposure limit 15 ppm (36 mg/m3), 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 10 ppm (24 mg/m3), short term exposure limit 15 ppm (36 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (24 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (4.9 mg/m3),KZG- week 4 ppm (9.8 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 ppm;
short term exposure limit 15 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 ppm;
short term exposure limit 15 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIMETHYLAMINE-air 10 hour time-weighted average 10 ppm;
short term exposure limit 15 ppm
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82039;
Number of Industries 6;
Total Number of Facilities 387;
Number of Occupations 11;
Total Number of Employees Exposed 3,900
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82039;
Number of Industries 7;
Total Number of Facilities 142;
Number of Occupations 13;
Total Number of Employees Exposed 5,261;
Total Number of Female Employees Exposed 2,870


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an insect attractant, warning agent in natural gas, flotation agent, and intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924-
CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SAPHAO Skandinavisches Archiv fuer Physiologie. (Stockholm, Sweden) V.1-83, 1899-1940. For publisher information, see APSCAX.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used as an insect attractant, warning agent in natural gas, flotation agent, and intermediate

NIOSH PROFILE (AMINES, TERTIARY ALIPHATIC), SRI, 2/77

RTECS Compound Description:
   Reproductive Effector

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