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Methacrylic acid, methyl ester

RTECS #: OZ5075000

CAS #: 80-62-6


UPDATE: May 2009 MW: 100.13 MF: C5H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2 - (Methoxycarbonyl) - 1 - propene
  2. 2 - Methyl - 2 - propenoic acid methyl ester
  3. 2 - Propenoic acid, 2 - methyl - , methyl ester
  4. Acrylic acid, 2 - methyl - , methyl ester
  5. MME
  6. Metakrylan metylu (Polish)
  7. Methacrylate de methyle (French)
  8. Methacrylsaeuremethyl ester (German)
  9. Methyl 2 - methyl - 2 - propenoate
  10. Methyl alpha - methylacrylate
  11. Methyl methacrylate
  12. Methyl methacrylate (ACGIH:OSHA)
  1. Methyl methacrylate monomer
  2. Methyl methylacrylate
  3. Methyl - 2 - methyl - 2 - propenoate
  4. Methyl - 2 - methylpropenoate
  5. Methyl - methacrylat (German)
  6. Methylester kyseliny methakrylove (Czech)
  7. Methylmethacrylaat (Dutch)
  8. Metil metacrilato (Italian)
  9. NCI - C50680
  10. Pegalan
  11. RCRA waste number U162


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
150 mg N/R INMEAF 14,292,1945
skin
rabbit
10 gm open irritation test N/R JIHTAB 23,343,1941


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 1,600 mg/L NTPTR* NTP-TR-314,1986
cytogenetic analysis mouse lymphocyte 2,799 mg/L EMMUEG 11,49,1988
cytogenetic analysis mouse lymphocyte 2,202 mg/L MUREAV 222,191,1989
cytogenetic analysis inhalation
rat
4 mg/m3/16 week BZARAZ 27(6),102,1974
mutation in microorganisms mouse lymphocyte 500 mg/L (+enzymatic activation step) ENMUDM 8(Suppl 6),4,1986
mutation in microorganisms Salmonella typhimurium 34 mmol/L (-enzymatic activation step) JBJSA3 61A,1203,1979
micronucleus test mouse lymphocyte 2,202 mg/L MUREAV 222,191,1989
mutation in mammalian somatic cells mouse lymphocyte 704 mg/L NTPTR* NTP-TR-314,1986
sister chromatid exchange hamster ovary 1,500 mg/L NTPTR* NTP-TR-314,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 116 ppm/6 hour (4-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NTIS** OTS0555600
inhalation
rat
lowest published toxic concentration: 109 gm/m3/17 minute (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 50,451,1979
inhalation
rat
lowest published toxic concentration: 109 gm/m3/54 minute (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
TXAPA9 50,451,1979
inhalation
rat
lowest published toxic concentration: 54 mg/m3/24 hour (8 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders GTPZAB 21(2),49,1977
inhalation
rat
lowest published toxic concentration: 4,480 mg/m3/2 hour (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TOLED5 31(Suppl),80,1986
inhalation
rat
lowest published toxic concentration: 500 mg/m3 (122 day prior to copulation) Reproductive: Other developmental abnormalities PREND* 37,51,1991
inhalation
rat
lowest published toxic concentration: 500 mg/m3 (119 day prior to copulation) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities
PROEAS 37,51,1991
inhalation
rat
lowest published toxic concentration: 500 mg/m3 (98 day prior to copulation/21 day pregnant) Reproductive: Other developmental abnormalities PROEAS 37,51,1991
inhalation
woman
lowest published toxic concentration: 10 mg/m3 (9 year pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on newborn: Delayed effects
GISAAA 62(4),19,1997
intraperitoneal
rat
lowest published toxic dose: 405 mg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities
JDREAF 51,1632,1972
intraperitoneal
rat
lowest published toxic dose: 801 mg/kg (5-15 day pregnant) Reproductive: Other developmental abnormalities JDREAF 51,1632,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
implant
rat
lowest published toxic dose: 1,620 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
CORTBR 88,223,1972


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published lethal concentration: 41,200 mg/m3/3 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
INMEAF 14,292,1945
inhalation
guinea pig
lowest published lethal concentration: 19,000 mg/m3/5 hour Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941
inhalation
human
lowest published toxic concentration: 125 ppm Behavioral: Sleep

Behavioral: Excitement

Behavioral: Anorexia (human)
GISAAA 19(10),25,1954
inhalation
human
lowest published toxic concentration: 60 mg/m3 Behavioral: Sleep

Behavioral: Excitement

Vascular: BP lowering not characterized in autonomic section
GTPZAB 1,56,1957
inhalation
mammal (species unspecified)
lethal concentration (50 percent kill): 20 gm/m3 N/R GISAAA 51(5),61,1986
inhalation
mouse
lethal concentration (50 percent kill): 18,500 mg/m3/2 hour N/R GTPZAB 20(6),5,1976
inhalation
rat
lethal concentration (50 percent kill): 78,000 mg/m3/4 hour N/R GTPZAB 20(6),5,1976
inhalation
rat
lowest published toxic concentration: 400 ppm/4 hour Olfaction: Ulcerated nasal septum

Olfaction: Other olfaction effects
TOXID9 60,150,2001
inhalation
rabbit
lowest published lethal concentration: 17,500 mg/m3/4.5 hour Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941
intraperitoneal
guinea pig
lethal dose (50 percent kill): 1,890 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
intraperitoneal
mouse
lethal dose (50 percent kill): 945 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
intraperitoneal
rat
lethal dose (50 percent kill): 1,328 mg/kg N/R JDREAF 51,1632,1972
intravenous
dog
lowest published lethal dose: 120 L/kg N/R JPMSAE 63,376,1974
oral
dog
lethal dose (50 percent kill): 4,725 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
INMEAF 14,292,1945
oral
guinea pig
lethal dose (50 percent kill): 5,954 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Changes in structure or function of salivary glands
INMEAF 14,292,1945
oral
mouse
lethal dose (50 percent kill): 3,625 mg/kg N/R GISAAA 41(4),6,1976
oral
rat
lethal dose (50 percent kill): 7,872 mg/kg Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941
oral
rabbit
lethal dose (50 percent kill): 8,700 mg/kg N/R GISAAA 41(4),6,1976
subcutaneous
cat
lowest published lethal dose: 7 mL/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
NTIS** OTS0520933
subcutaneous
dog
lethal dose (50 percent kill): 4,252 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
subcutaneous
guinea pig
lethal dose (50 percent kill): 5,954 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
subcutaneous
mouse
lethal dose (50 percent kill): 5,954 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
subcutaneous
rat
lethal dose (50 percent kill): 7,088 mg/kg Behavioral: Somnolence (general depressed activity) INMEAF 14,292,1945
subcutaneous
rabbit
lowest published lethal dose: 14 mL/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Hematuria
NTIS** OTS0520933
skin
human
lowest published toxic concentration: 2 pph Skin: After topical application: Dermatitis, allergic AJCDE* 13,108,2002
skin
rabbit
lethal dose (50 percent kill): >5 gm/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0544282


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 15 gm/m3/7 hour/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** OTS0520933
inhalation
dog
lowest published toxic concentration: 47 gm/m3/90 minute/15 day- intermittent Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
INMEAF 14,292,1945
inhalation
guinea pig
lowest published toxic concentration: 65 gm/m3/3 hour/3 day- intermittent Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
INMEAF 14,292,1945
inhalation
hamster
lowest published toxic concentration: 400 ppm/6 hour/78 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0521056
inhalation
mouse
lowest published toxic concentration: 41 gm/m3/90 minute/15 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field INMEAF 14,292,1945
inhalation
mouse
lowest published toxic concentration: 5,000 ppm/6 hour/14 week- intermittent Olfaction: Other olfaction effects

Liver: Hepatitis (hepatocellular necrosis), zonal

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-314,1986
inhalation
mouse
lowest published toxic concentration: 500 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)
TXCYAC 52,237,1988
inhalation
mouse
lowest published toxic concentration: 30,900 mg/kg/103 week- intermittent Reproductive: Tumorigenic effects: Uterine tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB87-146742/AS
inhalation
rat
lowest published toxic concentration: 116 ppm/8 hour/26 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: P

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
ENVRAL 11,66,1976
inhalation
rat
lowest published toxic concentration: 5,000 ppm/6 hour/14 week- intermittent Brain and Coverings: Changes in circulation

Olfaction: Other olfaction effects

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-314,1986
inhalation
rat
lowest published toxic concentration: 34,500 mg/m3/16 week- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
GISAAA 45(10),74,1980
inhalation
rat
lowest published toxic concentration: 1 mg/m3/24 hour/60 day- continuous Behavioral: Muscle contraction or spasticity

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
GISAAA 27(11),3,1962
inhalation
rat
lowest published toxic concentration: 115 mg/m3/3 hour/17 week- intermittent Cardiac: EKG changes not diagnostic of above

Blood: Other changes
GISAAA 45(1),34,1980
inhalation
rat
lowest published toxic concentration: 500 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)
TXCYAC 52,237,1988
inhalation
rat
lowest published toxic concentration: 50 mg/m3/4 hour/4 week- intermittent Endocrine: Change in LH

Endocrine: Change in gonadotropins

Related to Chronic Data: Changes in ovarian weight
PROEAS 37,51,1991
inhalation
rat
lowest published toxic concentration: 50 mg/m3/4 hour/17 week- intermittent Brain and Coverings: Other degenerative changes PROEAS 37,51,1991
inhalation
rat
lowest published toxic concentration: 15,450 mg/kg/103 week- intermittent Brain and Coverings: Tumors

Tumorigenic: Active as anti-cancer agent
NTIS** PB87-146742/AS
inhalation
rat
lowest published toxic concentration: 50 mg/m3/4 hour/30 day- intermittent Endocrine: Change in LH

Endocrine: Change in gonadotropins

Related to Chronic Data: Changes in ovarian weight
PREND* 37,51,1991
inhalation
rat
lowest published toxic concentration: 500 mg/m3/4 hour/122 day- intermittent Endocrine: Other changes PREND* 37,51,1991
inhalation
rabbit
lowest published toxic concentration: 15 gm/m3/7 hour/5 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
NTIS** OTS0520933
intraperitoneal
mouse
lowest published toxic dose: 19,665 mL/kg/15 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JBMRBG 8,11,1974
oral
dog
lowest published toxic dose: 1,825 mg/kg/2 year- continuous Endocrine: Changes in spleen weight TXAPA9 6,29,1964
oral
rat
lowest published toxic dose: 10,500 mg/kg/21 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Behavioral: Somnolence (general depressed activity)

Biochemical: Metabolism (intermediary): Lipids including transport
INHEAO 27,121,1989
oral
rat
lowest published toxic dose: 17,896 mg/kg/35 week- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
AMPMAR 32,653,1971
oral
rabbit
lowest published toxic dose: 97,500 g/kg/39 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 41(4),6,1976
skin
human
lowest published toxic concentration: 2 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,177,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm;short term exposure limit 100 ppm (sen) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 19,187,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 19,187,1979
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 60,445,1994
International Agency for Research on Cancer (IARC) Cancer Review Animal LACK CARCINOGENICITY IMEMDT 60,445,1994
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 60,445,1994
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
TOLED5 138,9,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
IJTOFN 24,53,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 100 ppm (410 mg/m3) DTLVS* 3,168,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (410 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (208 mg/m3), short term exposure limit 100 ppm (416 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (416 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (102 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (410 mg/m3), short term exposure limit 150 ppm (615 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (410 mg/m3), VLE 200 ppm (820 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 210 mg/m3 (50 mL/m3) (skin, sen), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 210 mg/m3, short term exposure limit 210 mg/m3, Skin, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 100 ppm (410 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 100 ppm (410 mg/m3);
short term exposure limit 125 ppm (510 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 40 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (208 mg/m3);
short term exposure limit 100 ppm (416 mg/m3), skin, sen, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (410 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 50 mg/m3, MAC(short term exposure limit) 400 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (200 mg/m3);
short term exposure limit 150 ppm (600 mg/m3), Skin, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (210 mg/m3),KZG- week 100 ppm (420 mg/m3), dayEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (208 mg/m3);
short term exposure limit 100 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not classifiable as human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL METHACRYLATE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 47700;
Number of Industries 89;
Total Number of Facilities 11,522;
Number of Occupations 73;
Total Number of Employees Exposed 89,435
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 47700;
Number of Industries 76;
Total Number of Facilities 6,757;
Number of Occupations 80;
Total Number of Employees Exposed 170,079;
Total Number of Female Employees Exposed 59,519


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a chemical intermediate in the plastics industry
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Methyl methacrylate, 2537
NCI Carcinogenesis Studies (inhal);no evidence:mouse,rat
OSHA ANALYTICAL METHOD #94


REFERENCES:

CODEN
REFERENCE

AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.19- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CORTBR Clinical Orthopaedics and Related Research. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) No.26- 1963-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher information, see IOHSA5.
JBJSA3 Journal of Bone and Joint Surgery, American Volume. (10 Shattuck St., Boston, MA 02115) V.30- 1948-
JBMRBG Journal of Biomedical Materials Research. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10158) V.1- 1967-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PREND* Problemi Endocrinologii. (Endocrinology problems, 117819, Nauchnii proesd, 6, Moscow, Russia) V36- 1991-
PROEAS Problemy Endokrinologii. Problems of Endocrinology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-6, 1936-41; 13- 1967-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a chemical intermediate in the plastics industry

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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