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Methacrylic acid

RTECS #: OZ2975000

CAS #: 79-41-4


UPDATE: May 2009 MW: 86.10 MF: C4H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Methylpropenoic acid
  2. 2 - Propenoic acid, 2 - methyl - (9CI)
  3. Acrylic acid, 2 - methyl -
  4. Kyselina methakrylova (Czech)
  1. Methacrylic acid (ACGIH)
  2. No Lift Nails Primer
  3. Propionic acid, 2 - methylene -
  4. alpha - Methylacrylic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA adduct Escherichia coli 50 Ámol/L MUREAV 89,95,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 170 mg/m3 Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
TOVEFN (4),23,2000
inhalation
rat
lowest published toxic concentration: 120 mg/m3 Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
TOVEFN (4),23,2000
intraperitoneal
mouse
lethal dose (50 percent kill): 48 mg/kg N/R JPMSAE 62,778,1973
intravenous
dog
lowest published lethal dose: 95,200 nL/kg N/R JPMSAE 63,376,1974
oral
child
lowest published toxic dose: 250 ÁL/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Gastrointestinal: Nausea or vomiting

Skin: After systemic exposure: Dermatitis, other
PEDIAU 102,979,1998
oral
mouse
lethal dose (50 percent kill): 1,250 mg/kg N/R GTPZAB 25(11),57,1981
oral
rat
lethal dose (50 percent kill): 1,060 mg/kg N/R TOVEFN (4),23,2000
oral
rabbit
lethal dose (50 percent kill): 1,200 mg/kg N/R GISAAA 38(8),13,1973
skin
guinea pig
lethal dose (50 percent kill): 1 gm/kg N/R 38MKAJ 2C,4953,1982
skin
rabbit
lethal dose (50 percent kill): 500 mg/kg N/R 85INA8 5,362,1986
unreported route
mouse
lethal dose (50 percent kill): 1,250 mg/kg N/R GISAAA 49(10),64,1984
unreported route
rat
lethal dose (50 percent kill): 1,600 mg/kg N/R GISAAA 49(10),64,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 221 mg/m3/24 hour/17 week- continuous Behavioral: Alteration of classical conditioning GISAAA 46(5),10,1981
inhalation
rat
lowest published toxic concentration: 221 mg/m3/24 hour/17 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases GISAAA 46(5),10,1981
oral
rat
lowest published toxic dose: 910 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 38(8),13,1973
oral
rabbit
lowest published toxic dose: 910 mg/kg/26 week- intermittent Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
GISAAA 38(8),13,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 20 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
EVHPAZ 11,141,1975
TOXICOLOGY REVIEW
IJTOFN 24,33,2005
TOXICOLOGY REVIEW
HPCQA4 38,527,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 20 ppm (70 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 20 ppm (71 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 20 ppm (70 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 20 ppm, JAN1999
Occupational Exposure Limit - FRANCE VME 20 ppm (70 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 18 mg/m3 (5 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 20 ppm (70 mg/m3), 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 70 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 20 ppm (70 mg/m3), JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 20 ppm (70 mg/m3);
short term exposure limit 30 ppm (100 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (18 mg/m3),KZG- week 10 ppm (36 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 20 ppm (72 mg/m3);
short term exposure limit 40 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 20 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 20 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHACRYLIC ACID-air 10 hour time-weighted average 20 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3304;
Number of Industries 12;
Total Number of Facilities 1,529;
Number of Occupations 31;
Total Number of Employees Exposed 18,977
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3304;
Number of Industries 109;
Total Number of Facilities 10,110;
Number of Occupations 75;
Total Number of Employees Exposed 145,414;
Total Number of Female Employees Exposed 46,453


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in preparation of methacrylates and carboxylated polymers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HPCQA4 Human Pathology. (W.B. Saunders Co., W. Washington Sq., Philadelphia, PA 19105) V.1- 1970-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

Used in preparation of methacrylates and carboxylated polymers

RTECS Compound Description:
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   Mutagen
   Human Data

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