Methacrylic acid

RTECS #

OZ2975000

CAS #

79-41-4
See: NMAM or OSHA Methods

Updated

December 2018

Molecular Weight

86.10

Molecular Formula

C₄H₆O₂

Synonyms

2-Methylpropenoic acid
2-Propenoic acid, 2-methyl- (9CI)
Acrylic acid, 2-methyl-
alpha-Methylacrylic acid
Kyselina methakrylova (Czech)
Methacrylic acid (ACGIH)
No Lift Nails Primer
Propionic acid, 2-methylene-

Mutation Data and Reference

System Test	Route/Organism/Tissue	Dose	Reference
DNA adduct	/Escherichia coli	50 µmol/L	MUREAV 89,95,1981

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/human	lowest published toxic concentration: 170 mg/m³	Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes	TOVEFN (4),23,2000
inhalation/rat	lowest published toxic concentration: 120 mg/m³	Lung, Thorax, or Respiration: Dyspnea Lung, Thorax, or Respiration: Other changes	TOVEFN (4),23,2000
intraperitoneal/mouse	lethal dose (50 percent kill): 48 mg/kg		JPMSAE 62,778,1973
intravenous/Dog	lowest published lethal dose: 95200 nL/kg		JPMSAE 63,376,1974
oral/child	lowest published toxic dose: 250 µL/kg	Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi Gastrointestinal: Nausea or vomiting Skin: After systemic exposure: Dermatitis, other	PEDIAU 102,979,1998
oral/mouse	lethal dose (50 percent kill): 1250 mg/kg		GTPZAB 25(11),57,1981
oral/rabbit	lethal dose (50 percent kill): 1200 mg/kg		GISAAA 38(8),13,1973
oral/rat	lethal dose (50 percent kill): 1060 mg/kg		TOVEFN (4),23,2000
skin/guinea pig	lethal dose (50 percent kill): 1 gm/kg		38MKAJ 2C,4953,1982
skin/rabbit	lethal dose (50 percent kill): 500 mg/kg		85INA8 5,362,1986
unreported route/mouse	lethal dose (50 percent kill): 1250 mg/kg		GISAAA 49(10),64,1984
unreported route/rat	lethal dose (50 percent kill): 1600 mg/kg		GISAAA 49(10),64,1984

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/mouse	lowest published toxic concentration: 221 mg/m³/24H/17W- continuous	Behavioral: Alteration of classical conditioning	GISAAA 46(5),10,1981
inhalation/rat	lowest published toxic concentration: 221 mg/m³/24H/17W- continuous	Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases	GISAAA 46(5),10,1981
oral/rabbit	lowest published toxic dose: 910 mg/kg/26W- intermittent	Liver: Liver function tests impaired Nutritional and Gross Metabolic: Changes in: Metabolic acidosis	GISAAA 38(8),13,1973
oral/rat	lowest published toxic dose: 910 mg/kg/26W- intermittent	Behavioral: Alteration of classical conditioning	GISAAA 38(8),13,1973

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 20 ppm	DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEW		EVHPAZ 11,141,1975
TOXICOLOGY REVIEW		IJTOFN 24,33,2005
TOXICOLOGY REVIEW		HPCQA4 38,527,2007
TOXICOLOGY REVIEW		FCTOD7 47,1287,2009
TOXICOLOGY REVIEW		DERCL* 27,289,2009
TOXICOLOGY REVIEW		FCTOD7 55,596,2013
TOXICOLOGY REVIEW		RTOPDW 54,247,2009
TOXICOLOGY REVIEW		RTOPDW 55,43,2009

Standards and Regulations

Organization	Standard	Reference
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 20 ppm (70 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 20 ppm (70 mg/m³), 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 20 ppm (71 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 20 ppm (70 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 20 ppm (71 mg/m³), NOV2011
Occupational Exposure Limit-FRANCE	VME 20 ppm (70 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 5 ppm (18 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 20 ppm (70 mg/m³), NOV2011
Occupational Exposure Limit-JAPAN	Occupational Exposure Limit 2 ppm, MAY2012
Occupational Exposure Limit-KOREA	time-weighted average 20 ppm (70 mg/m³), 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 20 ppm (70 mg/m³), JAN2002
Occupational Exposure Limit-PERU	time-weighted average 20 ppm (70 mg/m³), JUL2005
Occupational Exposure Limit-RUSSIA	short term exposure limit 10 mg/m³, JUN2003
Occupational Exposure Limit-SWEDEN	time-weighted average 20 ppm (70 mg/m³);short term exposure limit 30 ppm (100 mg/m³), JUN2005
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 ppm (18 mg/m³), KZG-week 10 ppm (36 mg/m³), JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 70 mg/m³, 2003
Occupational Exposure Limit-UNITED KINGDOM	time-weighted average 20 ppm (72 mg/m³);short term exposure limit 40 ppm (143 mg/m³), OCT2007

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHACRYLIC ACID-air	10H time-weighted average 20 ppm (Sk)	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code M3304; Number of Industries 109; Total Number of Facilities 10110; Number of Occupations 75; Total Number of Employees Exposed 145414; Total Number of Female Employees Exposed 46453
National Occupational Hazard Survey 1974	Hazard Code M3304; Number of Industries 12; Total Number of Facilities 1529; Number of Occupations 31; Total Number of Employees Exposed 18977

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health