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Lactonitrile, 2 - methyl -

RTECS #: OD9275000

CAS #: 75-86-5


UPDATE: May 2009 MW: 85.12 MF: C4H7NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Hydroxy - 2 - methylpropionitrile
  2. 2 - Methyllactonitrile
  3. Acetoncianhidrinei (Romanian)
  4. Acetoncianidrina (Italian)
  5. Acetoncyaanhydrine (Dutch)
  6. Acetoncyanhydrin (German)
  7. Acetonecyanhydrine (French)
  8. Acetone cyanohydrin
  1. Acetone cyanohydrin (ACGIH)
  2. Acetonkyanhydrin (Czech)
  3. Cyanhydrine d'acetone (French)
  4. Propanenitrile, 2 - hydroxy - 2 - methyl -
  5. RCRA waste number P069
  6. USAF RH - 8
  7. alpha - Hydroxyisobutyronitrile


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (30 percent kill): 70 mg/m3/2 hour N/R 85GMAT -,15,1982
inhalation
rat
lowest published lethal concentration: 63 ppm/4 hour N/R AIHAAP 23,95,1962
intraperitoneal
mouse
lethal dose (50 percent kill): 1 mg/kg N/R NTIS** AD277-689
oral
guinea pig
lethal dose (50 percent kill): 9 mg/kg N/R NTIS** PB214-270
oral
mammal (species unspecified)
lowest published toxic dose: 0.14 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOVEFN (1),29,1994
oral
mouse
lethal dose (50 percent kill): 1,898 g/kg N/R TOVEFN (1),29,1994
oral
rat
lethal dose (50 percent kill): 5.9 mg/kg N/R TOVEFN (1),29,1994
oral
rabbit
lethal dose (50 percent kill): 13,500 g/kg N/R NTIS** PB214-270
subcutaneous
rat
lethal dose (50 percent kill): 8,500 g/kg Blood: Other changes BJIMAG 19,283,1962
skin
guinea pig
lethal dose (50 percent kill): 150 mg/kg N/R AMIHBC 8,371,1953
skin
rabbit
lethal dose (50 percent kill): 17 L/kg N/R AIHAAP 23,95,1962
unreported route
mouse
lethal dose (50 percent kill): 2,900 g/kg N/R GISAAA 31(6),8,1966
unreported route
rat
lethal dose (50 percent kill): 13,300 g/kg N/R GISAAA 31(6),8,1966


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 3,634 mg/kg/35 week- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Liver: Other changes
AMPMAR 32,653,1971
oral
rat
lowest published toxic dose: 0.84 mg/kg/30 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Other changes
TOVEFN (1),29,1994
oral
rat
lowest published toxic dose: 0.84 mg/kg/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases TOVEFN (1),29,1994
oral
rat
lowest published toxic dose: 1.27 mg/kg/26 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOVEFN (1),29,1994
oral
rat
lowest published toxic dose: 1.27 mg/kg/26 week- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOVEFN (1),29,1994
unreported route
rat
lowest published toxic dose: 242 mg/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 31(6),8,1966
unreported route
rabbit
lowest published toxic dose: 242 mg/kg/26 week- intermittent Liver: Liver function tests impaired

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
GISAAA 31(6),8,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 4.7 ppm(CN) (skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg(CN)/m3, JUL2008
Occupational Exposure Limit - BELGIUM short term exposure limit 4.7 ppm (5.1 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (3.5 mg(CN)/m3), OCT 2002
Occupational Exposure Limit - HUNGARY time-weighted average 16.7 mg/m3, short term exposure limit 16.7 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3.5 mg/m3, Skin, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 0.9 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETONE CYANOHYDRIN-air ceiling concentration 1 ppm/15 minute NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3298;
Number of Industries 2;
Total Number of Facilities 45;
Number of Occupations 2;
Total Number of Employees Exposed 1,016;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate for production of METHYLMETHACRYLATE, and in pharmaceuticals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Acetone cyanohydrin, 2506


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

Used as intermediate for production of METHYLMETHACRYLATE, and in pharmaceuticals

NIOSH PROFILE (NITRILES), SRC, 10/77

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