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Kerosene

RTECS #: OA5500000

CAS #: 8008-20-6


UPDATE: May 2009 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Coal oil
  2. Deobase
  3. Fuel oil No.5
  4. Kerosine
  1. Kerosine (petroleum)
  2. Nafta (Polish)
  3. Straight - run kerosene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg severe ATDAEI 1,30,1990
skin
rabbit
1,00%/24 hour moderate VCVPS* -,61,1998


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 25 ÁL/plate (+enzymatic activation step) CBTOE2 2,63,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 2,500 mg/m3/2 hour N/R VCVPS* -,59,1998
inhalation
dog
lowest published toxic concentration: 2,500 mg/m3/2 hour Behavioral: Tremor

Behavioral: Alteration of classical conditioning
VCVPS* -,59,1998
inhalation
rat
lethal concentration : >5 gm/m3/4 hour Behavioral: Somnolence (general depressed activity) ATDAEI 1,30,1990
intraperitoneal
rat
lowest published lethal dose: 10,700 mg/kg N/R TXAPA9 1,156,1959
intraperitoneal
rabbit
lethal dose (50 percent kill): 6,600 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion
AIMEAS 21,803,1944
intratracheal
dog
lowest published lethal dose: 800 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema
AJMSA9 221,531,1951
intratracheal
rat
lethal dose (50 percent kill): 800 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis
TXAPA9 1,462,1959
intratracheal
rabbit
lethal dose (50 percent kill): 200 mg/kg N/R TXAPA9 3,689,1961
intravenous
dog
lowest published lethal dose: 200 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema
AJMSA9 221,531,1951
intravenous
man
lowest published toxic dose: 403 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Hallucinations, distorted perceptions
CTOXAO 10,283,1977
intravenous
rabbit
lethal dose (50 percent kill): 180 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Tremor

Behavioral: Coma
AIMEAS 21,803,1944
oral
dog
lowest published lethal dose: 4 gm/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema
AJMSA9 221,531,1951
oral
domestic animal
lowest published toxic dose: 10 mL/kg Behavioral: Muscle weakness

Gastrointestinal: Decreased motility or constipation

Nutritional and Gross Metabolic: Body temperature increase
VHTODE 42,354,2000
oral
domestic animal
lowest published toxic dose: 20 mL/kg Cardiac: Change in rate

Lung, Thorax, or Respiration: Cough
VHTODE 42,354,2000
oral
guinea pig
lethal dose (50 percent kill): 20 gm/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hypoglycemia
AIMEAS 21,803,1944
oral
human
lowest published toxic concentration: 5.7 mg/kg N/R VCVPS* -,60,1998
oral
human
lowest published toxic concentration: 5.7 mg/kg Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Nausea or vomiting
VCVPS* -,60,1998
oral
man
lowest published toxic dose: 3,570 mg/kg Lung, Thorax, or Respiration: Cough

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Body temperature increase
TORAAK 15,263,1966
oral
man
lowest published lethal dose: 500 mg/kg N/R YAKUD5 22,883,1980
oral
rat
lethal dose : >5 gm/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea
ATDAEI 1,30,1990
oral
rat
lethal dose (50 percent kill): 15 gm/kg Skin: After topical application: Corrosive VCVPS* -,59,1998
oral
rabbit
lethal dose (50 percent kill): 2,835 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation

Endocrine: Hypoglycemia
AIMEAS 21,803,1944
subcutaneous
rat
lowest published toxic concentration: 5 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage
VCVPS* -,60,1998
skin
rabbit
lethal dose : >2 gm/kg N/R ATDAEI 1,30,1990
unreported route
man
lowest published lethal dose: 1,176 mg/kg N/R 85DCAI 2,73,1970
unreported route
rat
lowest published lethal dose: 2 mg/kg Gastrointestinal: Peritonitis VCVPS* -,60,1998
unreported route
rat
lowest published toxic concentration: 2 mg/kg Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Nausea or vomiting
VCVPS* -,60,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
cat
lowest published toxic concentration: 500 mg/m3/4 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count
VCVPS* -,60,1998
inhalation
guinea pig
lowest published toxic concentration: 20,400 mg/m3/21 day- intermittent Vascular: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
VCVPS* -,60,1998
inhalation
human
lowest published toxic concentration: 250 mg/m3/4 year- intermittent Behavioral: Excitement

Behavioral: Irritability
VCVPS* -,61,1998
inhalation
human
lowest published toxic concentration: 0.15 mg/m3/5 year- intermittent Lung, Thorax, or Respiration: Fibrosis (interstitial) VCVPS* -,61,1998
inhalation
mouse
lowest published toxic concentration: 500 mg/m3/4 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count
VCVPS* -,60,1998
inhalation
rat
lowest published toxic concentration: 500 mg/m3/4 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count
VCVPS* -,60,1998
inhalation
rat
lowest published toxic concentration: 300 mg/m3/12 week- intermittent Blood: Normocytic anemia

Blood: Luekopenia
VCVPS* -,61,1998
inhalation
rabbit
lowest published toxic concentration: 500 mg/m3/4 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in leukocyte (WBC) count
VCVPS* -,60,1998
inhalation
rabbit
lowest published toxic concentration: 300 mg/m3/12 week- intermittent Blood: Normocytic anemia

Blood: Luekopenia
VCVPS* -,61,1998
oral
rat
lowest published toxic dose: 540 gm/kg/90 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in adrenal weight

Endocrine: Antidiuresis
BCTKAG 21,187,1988
oral
rat
lowest published toxic dose: 405 gm/kg/17 week- intermittent Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair
VCVPS* -,61,1998
subcutaneous
rat
lowest published toxic dose: 84 gm/kg/35 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
ENVRAL 35,516,1984
subcutaneous
rat
lowest published toxic dose: 11.9 gm/kg/35 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Liver: Multiple effects
VCVPS* -,61,1998
skin
rabbit
lowest published toxic dose: 4,500 mg/kg/3 week- intermittent Blood: Pigmented or nucleated red blood cells

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0533973
skin
rabbit
lowest published toxic dose: 2,400 mg/kg/28 day- intermittent Endocrine: Changes in spleen weight

Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair
NTIS** OTS0541008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 mg/m3 (skin) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not classifiable as human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 45,39,1989
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
ENTOX* -,385,2005
TOXICOLOGY REVIEW
JTEHD6 4,223,2001
TOXICOLOGY REVIEW
HUTOX* -,683,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,225,1998
Occupational Exposure Limit - BELGIUM time-weighted average 200 mg/m3, Skin, MAR2002
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 300 mg( continuous)/m3, short term exposure limit 600 mg( continuous)/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO KEROSENE-air 10 hour time-weighted average 100 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T1768;
Number of Industries 321;
Total Number of Facilities 69,564;
Number of Occupations 186;
Total Number of Employees Exposed 1,075,728;
Total Number of Female Employees Exposed 96,255
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6889;
Number of Industries 1;
Total Number of Facilities 22;
Number of Occupations 3;
Total Number of Employees Exposed 790


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264222/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8968
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Naphthas, 1550


REFERENCES:

CODEN
REFERENCE

85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841-
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
CBTOE2 Cell Biology and Toxicology. (Princeton Scientific Pub., Inc., 301 N. Harrison St., CN 5279, Princeton, NJ 08540) V.1- 1984-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TORAAK El Torax. (Montevideo, Uruguay) V.1- 1952-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVPS* "Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia" (Hazardous substances. Nature products.) Volkova N.V. et al., Sankt-Peterburg, 1998.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

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