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Isocyanic acid, methylene (3,5,5 - trimethyl - 3,1 - cyclohexylene) ester

RTECS #: NQ9370000

CAS #: 4098-71-9


UPDATE: May 2009 MW: 222.32 MF: C12H18N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3 - Isocyanatomethyl - 3,5,5 - trimethylcyclohexylisocyanate
  2. Cyclohexane, 5 - isocyanato - 1 - (isocyanatomethyl) - 1,3,3 - trimethyl - (9CI)
  3. IPDI
  1. Isophorone diamine diisocyanate
  2. Isophorone diisocyanate
  3. Isophorone diisocyanate (ACGIH)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 415 mg/kg (8-12 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) WDZAEK 5,178,1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lethal concentration (50 percent kill): 118 mg/m3/1 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0543418
inhalation
rat
lethal concentration (50 percent kill): 123 mg/m3/4 hour N/R 85INA8 5,334(86),1986
inhalation
rat
lowest published toxic concentration: 7.5 mg/m3/6 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Changes in lung weight
JAPTO* 24,231,2004
inhalation
rat
lowest published toxic concentration: 2.1 mg/m3/6 hour Lung, Thorax, or Respiration: Other changes JAPTO* 24,231,2004
inhalation
rat
lowest published toxic concentration: 7.5 mg/m3/6 hour Nutritional and Gross Metabolic: Body temperature decrease JAPTO* 24,231,2004
oral
cat
lethal dose (50 percent kill): 1 mL/kg N/R NTIS** OTS0528418
oral
mouse
lowest published lethal dose: 2,500 L/kg N/R NTIS** OTS0528418
oral
rat
lethal dose (50 percent kill): 4,825 mg/kg N/R NTIS** OTS0530238
skin
rat
lowest published lethal dose: 1 mL/kg N/R NTIS** OTS0528418


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,370 g/m3/4 hour/4 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0528418
skin
mouse
lowest published toxic dose: 0.3 pph/2 day- intermittent Blood: Other changes

Skin: After topical application: Cutaneous sensitization (experimental)
TOXID9 72,101,2003
skin
mouse
lowest published toxic dose: 220 mg/kg/12 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 207,487,2005
skin
mouse
lowest published toxic dose: 1 pph/5 day- continuous Skin: After systemic exposure: Dermatitis, irritative NTPTR* IMM-90001.
skin
mouse
lowest published toxic dose: 480 mg/kg/28 day- intermittent Immunological Including Allergic: Increase in humoral response TOSCF2 94,108,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
TOLED5 140-141,213,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 0.02 mg(NCO)/m3, short term exposure limit 0.07 mg(NCO)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.005 ppm (0.046 mg/m3), Skin, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.045 mg/m3), OCT 2002
Occupational Exposure Limit - FRANCE VME 0.01 ppm (0.09 mg/m3), VLE 0.02 ppm (0.18 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.046 mg/m3 (0.005 mL/m3) (airway, skin, sen), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.005 ppm (0.045 mg/m3), skin, 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.01 ppm (0.09 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.005 ppm (0.045 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.002 ppm (0.018 mg/m3), ceiling concentration 0.005 ppm (0.046 mg/m3), Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.005 ppm (0.02 mg/m3),KZG- week 0.005 ppm (0.02 mg/m3), DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.005 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.005 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IPDI-air 10 hour time-weighted average 0.005 ppm (Sk);
short term exposure limit 0.02 ppm (Sk)
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83571;
Number of Industries 4;
Total Number of Facilities 111;
Number of Occupations 19;
Total Number of Employees Exposed 3,441
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83571;
Number of Industries 15;
Total Number of Facilities 1,186;
Number of Occupations 16;
Total Number of Employees Exposed 7,245;
Total Number of Female Employees Exposed 682


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

RTECS Compound Description:
   Reproductive Effector

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