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Isocyanic acid, methylenedi - 4,1 - cyclohexylene ester

RTECS #: NQ9250000

CAS #: 5124-30-1

UPDATE: February 2009 MW: 262.39 MF: C15H22N2O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 4,4' - Diisocyanatodicyclohexylmethane
  2. Bis (4 - isocyanatocyclohexyl) methane
  3. CP 99173
  4. Cyclohexane, 1,1' - methylenebis (4 - isocyanato - (9CI)
  5. Dicyclohexylmethane - 4,4' - diisocyanate
  6. Hydrogenated MDI
  1. Hylene W
  2. Methylene bis (4 - cyclohexylisocyanate)
  3. Methylene bis (4 - cyclohexylisocyanate) (ACGIH)
  4. Methylene bis - (4 - cyclohexylisocyanate)
  5. Nacconate H 12


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL mild NTIS** OTS0530188
eye
rabbit 		100 µL/24 hour severe NTIS** OTS0555173
skin
rabbit 		500 µL/24 hour moderate NTIS** OTS0555173


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 51 mg/m3/1 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0534736
inhalation
rat 		lowest published lethal concentration: 20 ppm/5 hour N/R 85INA8 6,998,1991
inhalation
rat 		lowest published lethal concentration: 431 mg/m3/4 hour N/R ARTODN 78,243,2004
oral
rat 		lethal dose (50 percent kill): 9,900 mg/kg Behavioral: Food intake (animal)

Gastrointestinal: Hypermotility, diarrhea

Liver: Other changes 		NTIS** OTS000555173
skin
rabbit 		lethal dose : >10 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Muscle weakness 		NTIS** OTS0555173


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 220 mg/kg/12 day- intermittent Skin: After topical application: Cutaneous sensitization (experimental)

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXCYAC 207,487,2005
skin
mouse 		lowest published toxic dose: 2 pph/2 week- intermittent Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increase in humoral response 		TOXID9 78,260,2004
skin
mouse 		lowest published toxic dose: 2 pph/4 week- intermittent Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Increase in humoral response 		TOXID9 78,260,2004
skin
mouse 		lowest published toxic dose: 280 mg/kg/14 day- intermittent Immunological Including Allergic: Increase in humoral response TOSCF2 94,108,2006
skin
mouse 		lowest published toxic dose: 480 mg/kg/28 day- intermittent Lung, Thorax, or Respiration: Other changes TOSCF2 94,108,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
TOLED5 140-141,213,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - BELGIUM time-weighted average 0.005 ppm (0.055 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.005 ppm (0.054 mg/m3), OCT 2002
Occupational Exposure Limit - MEXICO time-weighted average 0.01 ppm (0.11 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.1 1 mg/m3, Skin, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.02 mg(NCO)/m3;
short term exposure limit 0.07 mg(NCO)/m3, sen, JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.005 ppm (0.05 mg/m3), JAN1999
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.005 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.005 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICYCLOHEXYLMETHANE 4,4'-DIISOCYANATE-air ceiling concentration 0.01 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1655;
Number of Industries 6;
Total Number of Facilities 102;
Number of Occupations 22;
Total Number of Employees Exposed 4,022
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1175;
Number of Industries 16;
Total Number of Facilities 624;
Number of Occupations 18;
Total Number of Employees Exposed 7,764;
Total Number of Female Employees Exposed 637


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Primary Irritant

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