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Iron carbonyl

RTECS #: NO4900000

CAS #: 13463-40-6


UPDATE: May 2009 MW: 195.90 MF: C5FeO5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. FER pentacarbonyle (French)
  2. Iron carbonyl (Fe (CO) 5) , (TB - 5 - 11) (9CI)
  3. Iron pentacarbonyl
  1. Iron pentacarbonyl (ACGIH)
  2. Iron, pentacarbonyl -
  3. Pentacarbonyliron


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 140 ppm/30 minute N/R EPASR* 8EHQ-0591-1177
inhalation
mouse
lethal concentration (50 percent kill): 2,190 mg/m3/30 minute N/R AMIHAB 19,11,1959
inhalation
rat
lethal concentration (50 percent kill): 10 ppm/4 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0535889
inhalation
rabbit
lowest published lethal concentration: 250 ppm/45 minute N/R 34ZIAG -,335,1969
intraperitoneal
mouse
lethal dose (50 percent kill): 60 mg/kg N/R EPASR* 8EHQ-0591-1177
intravenous
rabbit
lethal dose (50 percent kill): 11 mg/kg N/R JIHTAB 25,415,1943
oral
cat
lethal dose (50 percent kill): 100 mg/kg N/R EPASR* 8EHQ-0591-1177
oral
guinea pig
lethal dose (50 percent kill): 22 mg/kg N/R JIHTAB 25,415,1943
oral
mouse
lethal dose (50 percent kill): 62 mg/kg N/R GTPZAB 26(6),52,1982
oral
rat
lethal dose (50 percent kill): 25 mg/kg N/R EPASR* 8EHQ-0591-1177
oral
rat
lowest published toxic dose: 40 gm/kg Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Changes in: Fe
RTOPDW 36,280,2002
oral
rabbit
lethal dose (50 percent kill): 12 mg/kg N/R JIHTAB 25,415,1943
subcutaneous
rabbit
lethal dose (50 percent kill): 240 mg/kg N/R JIHTAB 25,415,1943
skin
rabbit
lethal dose (50 percent kill): 56 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0535885


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 15 ppm/6 hour/2 day- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Cyanosis

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
BJIMAG 27,1,1970
oral
rat
lowest published toxic dose: 157.5 gm/kg/6 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Fe
TOLED5 133,193,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm;short term exposure limit 0.2 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
AEHLAU 23,373,1971


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.01 ppm (0.08 mg/m3) DTLVS* 3,137,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Fe)/m3, JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.23 mg(Fe)/m3), short term exposure limit 0.2 ppm (0.45 mg(Fe)/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.23 mg(Fe)/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.2 ppm (0.46 mg(Fe)/m3), MAR2002
Occupational Exposure Limit - BELGIUM time-weighted average 1 mg(Fe)/m3, MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.8 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.01 ppm (0.08 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.8 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.81 mg/m3 (0.1 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.8 mg/m3), short term exposure limit 0.2 ppm (1.6 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (0.2 mg(Fe)/m3);
short term exposure limit 0.2 ppm, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.08 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.23 mg(Fe)/m3);
short term exposure limit 0.2 ppm (0.45 mg(Fe)/m3), JAN2002
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.8 mg/m3),KZG- week 0.2 ppm (1.6 mg/m3),DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.01 ppm (0.08 mg(Fe)/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm;
short term exposure limit 0.2 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm;
short term exposure limit 0.2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IRON PENTACARBONYL (as Fe)-air time-weighted average 0.1 ppm;
short term exposure limit 0.2 ppm
NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6270;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 1,822;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to make finely divided iron, also used as antiknock agent and catalyst
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used to make finely divided iron, also used as antiknock agent and catalyst

NIOSH PROFILE (IRON AND ITS COMPOUNDS), SRC, 3/82

RTECS Compound Description:
   Organometallic

ALT CAS #: 37220-42-1
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