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Iodine

RTECS #: NN1575000

CAS #: 7553-56-2


UPDATE: May 2009 MW: 253.80 MF: I2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. IODE (French)
  2. Iodine crystals
  3. Iodine sublimed
  4. Iodine (ACGIH:OSHA)
  1. Iodio (Italian)
  2. Jod (German, Polish)
  3. Jood (Dutch)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 1,100 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) JONUAI 84,107,1964
oral
rat
lowest published toxic dose: 2,750 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JONUAI 84,107,1964
oral
rabbit
lowest published toxic dose: 15 mg/kg (30-31 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
JONUAI 87,394,1965


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 1 mg/m3 Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Acute pulmonary edema
VCVN5* -,400,1989
inhalation
mammal (species unspecified)
lowest published toxic concentration: 100 mg/m3 Endocrine: Other changes VCVN5* -,399,1989
inhalation
mammal (species unspecified)
lowest published toxic concentration: 10 mg/m3 Lung, Thorax, or Respiration: Cough VCVN5* -,399,1989
inhalation
rat
lowest published lethal concentration: 137 ppm/1 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature decrease
NTIS** OTS0555278
inhalation
rat
lowest published toxic concentration: 100 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
VCVN5* -,399,1989
intravenous
dog
lowest published lethal dose: 40 mg/kg N/R HBTXAC 5,76,1959
oral
dog
lowest published lethal dose: 800 mg/kg N/R HBAMAK 4,1289,1935
oral
human
lowest published lethal dose: 28 mg/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
34ZIAG -,330,1969
oral
human
lowest published toxic dose: 0.7 gm/kg Behavioral: Muscle weakness

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Renal function tests depressed
VCVN5* -,400,1989
oral
human
lowest published toxic dose: 25 mg/kg Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea
VCVN5* -,400,1989
oral
mouse
lethal dose (50 percent kill): 22 gm/kg N/R DRFUD4 4,876,1979
oral
mouse
lethal dose (50 percent kill): 1,000 mg/kg Behavioral: Change in motor activity (specific assay) VCVN5* -,399,1989
oral
rat
lethal dose (50 percent kill): 14 gm/kg N/R DRFUD4 4,876,1979
oral
rabbit
lethal dose (50 percent kill): 10 gm/kg N/R DRFUD4 4,876,1979
oral
rabbit
lowest published lethal dose: 5 mg/kg Blood: Other hemolysis with or without anemia VCVN5* -,399,1989
oral
woman
lowest published toxic dose: 26 mg/kg/1 year- intermittent Endocrine: Evidence of thyroid hyperfunction PGMJAO 62,661,1986
subcutaneous
mouse
lethal dose (50 percent kill): >8,650 mg/kg N/R NIIRDN -,1226,1990
subcutaneous
rat
lethal dose (50 percent kill): 10,500 mg/kg N/R NIIRDN -,1226,1990
subcutaneous
rabbit
lowest published lethal dose: 175 mg/kg N/R HBTXAC 5,76,1959
unreported route
man
lowest published lethal dose: 29 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 0.5 mg/m3/24 hour/8 week- continuous Olfaction: Change in sensation of smell VCVN5* -,400,1989
inhalation
rat
lowest published toxic concentration: 3.1 mg/m3/24 hour/13 week- continuous Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Renal function tests depressed

Endocrine: Other changes
VCVN5* -,400,1989
inhalation
rat
lowest published toxic concentration: 1.38 mg/m3/24 hour/13 week- continuous Behavioral: Change in motor activity (specific assay)

Behavioral: Aggression
VCVN5* -,400,1989
oral
rat
lowest published toxic dose: 746 mg/kg/14 week- continuous Blood: Other changes JTEHD6 32,89,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.1 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
FOREAE 7,313,1942
TOXICOLOGY REVIEW
KOTTAM 11,1300,1975
TOXICOLOGY REVIEW
HUTOX* -,661,1996
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,258,1998
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 0.1 ppm (1 mg/m3) DTLVS* 3,135,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 0.1 ppm (1 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 0.1 ppm (1 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 0.1 ppm (1 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 0.1 ppm (1 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (0.1 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA ceiling concentration 0.1 ppm (1 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (1 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK ceiling concentration 0.1 ppm (1 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 0.1 ppm (1 mg/m3), FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m3, short term exposure limit 1 mg/m3, Skin, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (1 mg/m3), APR2007
Occupational Exposure Limit - KOREA ceiling concentration 0.1 ppm (1 mg/m3), 2006
Occupational Exposure Limit - MEXICO peak 0.1 ppm (1 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 1 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND ceiling concentration 0.1 ppm (1 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN ceiling concentration 0.1 ppm (1 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (1 mg/m3),KZG- week 0.1 ppm (1 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 0.1 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (1 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.1 ppm (1.1 mg/m3), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.1 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO IODINE-air ceiling concentration 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 40030;
Number of Industries 51;
Total Number of Facilities 7,490;
Number of Occupations 46;
Total Number of Employees Exposed 124,917
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 40030;
Number of Industries 63;
Total Number of Facilities 6,179;
Number of Occupations 77;
Total Number of Employees Exposed 204,902;
Total Number of Female Employees Exposed 129,889


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a drinking water disinfectant
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Iodine, 6005
OSHA ANALYTICAL METHOD #ID-177


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FOREAE Food Research. (Champaign, IL) V.1-25, 1936-60. For publisher information, see JFDSAZ.
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
HTOPA*
HUTOX*
JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
KOTTAM Kogai to Taisaku. Journal of Environmental Pollution Control. (Kogai Taisaku Gijutsu Dokokai, Shuwa-Akasaka Bldg., 9-1-244, Akasaka, Minato-ku, Tokyo 107, Japan) V.1- 1965-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PGMJAO Postgraduate Medical Journal. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1925-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as a drinking water disinfectant

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

FDA-over the counter drug

RTECS Compound Description:
   Reproductive Effector
   Human Data

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